PMID- 32668299
OWN - NLM
STAT- MEDLINE
DCOM- 20210301
LR  - 20210301
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 221
DP  - 2020 Nov 1
TI  - Identification of the brain networks that contribute to the interaction between 
      physical function and working memory: An fMRI investigation with over 1,000 
      healthy adults.
PG  - 117152
LID - S1053-8119(20)30638-8 [pii]
LID - 10.1016/j.neuroimage.2020.117152 [doi]
AB  - There is a growing consensus regarding the positive relationship between physical 
      function and working memory; however, explanations of task-evoked functional 
      activity regarding this relationship and its differences in physical function 
      domains remain controversial. This study illustrates the cross-sectional 
      relationships between cardiorespiratory fitness, gait speed, hand dexterity, and 
      muscular strength with working memory task (N-back task) performance and the 
      mediating effects of task-evoked functional activity in 1033 adults aged between 
      22 and 37 years. The results showed that cardiorespiratory fitness and hand 
      dexterity were independently associated with N-back task performance to a greater 
      extent and in contrast to gait speed and muscular strength. These relationships 
      were mediated by task-evoked functional activity in a part of the frontoparietal 
      network (FPN) and default mode network (DMN). Superior cardiorespiratory fitness 
      could contribute to working memory performance by enhancing the compensational 
      role of FPN-related broader region activation. Hand dexterity was associated with 
      moderation of the interaction in terms of task-evoked activation between the FPN 
      and DMN, which in turn, improved N-back task performance. Based on these 
      findings, we conclude that cardiorespiratory fitness and hand dexterity have 
      common and unique mechanisms enhancing working memory.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - Ishihara, Toru
AU  - Ishihara T
AD  - Tamagawa University Brain Science Institute, Tokyo, Japan; Japan Society for the 
      Promotion of Science, Tokyo, Japan.
FAU - Miyazaki, Atsushi
AU  - Miyazaki A
AD  - Tamagawa University Brain Science Institute, Tokyo, Japan.
FAU - Tanaka, Hiroki
AU  - Tanaka H
AD  - Tamagawa University Brain Science Institute, Tokyo, Japan; Japan Society for the 
      Promotion of Science, Tokyo, Japan.
FAU - Matsuda, Tetsuya
AU  - Matsuda T
AD  - Tamagawa University Brain Science Institute, Tokyo, Japan. Electronic address: 
      tetsuya@lab.tamagawa.ac.jp.
LA  - eng
GR  - U54 MH091657/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200712
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Cardiorespiratory Fitness/*physiology
MH  - Cerebral Cortex/*physiology
MH  - *Connectome
MH  - Executive Function
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Motor Skills/*physiology
MH  - Muscle Strength/*physiology
MH  - Nerve Net/diagnostic imaging/*physiology
MH  - Prefrontal Cortex/physiology
MH  - Walking Speed/*physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Cardiorespiratory fitness
OT  - Cognitive control
OT  - Default mode network
OT  - Dorsolateral prefrontal cortex
OT  - Frontoparietal network
OT  - Hand dexterity
EDAT- 2020/07/16 06:00
MHDA- 2021/03/02 06:00
CRDT- 2020/07/16 06:00
PHST- 2020/03/26 00:00 [received]
PHST- 2020/06/30 00:00 [revised]
PHST- 2020/07/05 00:00 [accepted]
PHST- 2020/07/16 06:00 [pubmed]
PHST- 2021/03/02 06:00 [medline]
PHST- 2020/07/16 06:00 [entrez]
AID - S1053-8119(20)30638-8 [pii]
AID - 10.1016/j.neuroimage.2020.117152 [doi]
PST - ppublish
SO  - Neuroimage. 2020 Nov 1;221:117152. doi: 10.1016/j.neuroimage.2020.117152. Epub 
      2020 Jul 12.