PMID- 32669710 OWN - NLM STAT- MEDLINE DCOM- 20200908 LR - 20210521 IS - 1476-4687 (Electronic) IS - 0028-0836 (Linking) VI - 584 IP - 7819 DP - 2020 Aug TI - Antagonistic regulation of the gibberellic acid response during stem growth in rice. PG - 109-114 LID - 10.1038/s41586-020-2501-8 [doi] AB - The size of plants is largely determined by growth of the stem. Stem elongation is stimulated by gibberellic acid(1-3). Here we show that internode stem elongation in rice is regulated antagonistically by an 'accelerator' and a 'decelerator' in concert with gibberellic acid. Expression of a gene we name ACCELERATOR OF INTERNODE ELONGATION 1 (ACE1), which encodes a protein of unknown function, confers cells of the intercalary meristematic region with the competence for cell division, leading to internode elongation in the presence of gibberellic acid. By contrast, upregulation of DECELERATOR OF INTERNODE ELONGATION 1 (DEC1), which encodes a zinc-finger transcription factor, suppresses internode elongation, whereas downregulation of DEC1 allows internode elongation. We also show that the mechanism of internode elongation that is mediated by ACE1 and DEC1 is conserved in the Gramineae family. Furthermore, an analysis of genetic diversity suggests that mutations in ACE1 and DEC1 have historically contributed to the selection of shorter plants in domesticated populations of rice to increase their resistance to lodging, and of taller plants in wild species of rice for adaptation to growth in deep water. Our identification of these antagonistic regulatory factors enhances our understanding of the gibberellic acid response as an additional mechanism that regulates internode elongation and environmental fitness, beyond biosynthesis and gibberellic acid signal transduction. FAU - Nagai, Keisuke AU - Nagai K AD - Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan. FAU - Mori, Yoshinao AU - Mori Y AD - Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. FAU - Ishikawa, Shin AU - Ishikawa S AD - Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. FAU - Furuta, Tomoyuki AU - Furuta T AUID- ORCID: 0000-0002-0869-6626 AD - Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan. AD - Institute of Plant Science and Resources, Okayama University, Okayama, Japan. FAU - Gamuyao, Rico AU - Gamuyao R AUID- ORCID: 0000-0002-0112-6428 AD - Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan. FAU - Niimi, Yoko AU - Niimi Y AD - Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan. FAU - Hobo, Tokunori AU - Hobo T AUID- ORCID: 0000-0001-6709-2825 AD - Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan. FAU - Fukuda, Moyuri AU - Fukuda M AD - Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. FAU - Kojima, Mikiko AU - Kojima M AD - RIKEN Center for Sustainable Resource Science, Yokohama, Japan. FAU - Takebayashi, Yumiko AU - Takebayashi Y AD - RIKEN Center for Sustainable Resource Science, Yokohama, Japan. FAU - Fukushima, Atsushi AU - Fukushima A AUID- ORCID: 0000-0001-9015-1694 AD - RIKEN Center for Sustainable Resource Science, Yokohama, Japan. FAU - Himuro, Yasuyo AU - Himuro Y AD - RIKEN Center for Sustainable Resource Science, Yokohama, Japan. AD - RIKEN BioResource Research Center, Tsukuba, Japan. FAU - Kobayashi, Masatomo AU - Kobayashi M AD - RIKEN BioResource Research Center, Tsukuba, Japan. FAU - Ackley, Wataru AU - Ackley W AD - Institute of Livestock and Grassland Science, NARO, Nasushiobara, Japan. FAU - Hisano, Hiroshi AU - Hisano H AUID- ORCID: 0000-0001-8457-253X AD - Institute of Plant Science and Resources, Okayama University, Okayama, Japan. FAU - Sato, Kazuhiro AU - Sato K AUID- ORCID: 0000-0001-8818-5203 AD - Institute of Plant Science and Resources, Okayama University, Okayama, Japan. FAU - Yoshida, Aya AU - Yoshida A AD - Kihara Institute for Biological Research, Yokohama City University, Yokohama, Japan. FAU - Wu, Jianzhong AU - Wu J AUID- ORCID: 0000-0002-4033-852X AD - Institute of Crop Science, NARO, Tsukuba, Japan. FAU - Sakakibara, Hitoshi AU - Sakakibara H AD - Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan. AD - RIKEN Center for Sustainable Resource Science, Yokohama, Japan. FAU - Sato, Yutaka AU - Sato Y AD - National Institute of Genetics, Mishima, Japan. FAU - Tsuji, Hiroyuki AU - Tsuji H AUID- ORCID: 0000-0002-6444-559X AD - Kihara Institute for Biological Research, Yokohama City University, Yokohama, Japan. FAU - Akagi, Takashi AU - Akagi T AD - Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan. FAU - Ashikari, Motoyuki AU - Ashikari M AUID- ORCID: 0000-0002-8945-2366 AD - Bioscience and Biotechnology Center, Nagoya University, Nagoya, Japan. ashi@agr.nagoya-u.ac.jp. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200715 PL - England TA - Nature JT - Nature JID - 0410462 RN - 0 (Gibberellins) RN - 0 (Plant Growth Regulators) RN - 0 (Plant Proteins) RN - BU0A7MWB6L (gibberellic acid) SB - IM CIN - Nature. 2020 Aug;584(7819):44-45. PMID: 32669726 MH - Acclimatization MH - Gibberellins/*metabolism MH - Mutation MH - Oryza/genetics/*growth & development/*metabolism MH - Plant Growth Regulators/metabolism MH - Plant Proteins/genetics/metabolism MH - Plant Stems/genetics/*growth & development/*metabolism MH - Quantitative Trait Loci MH - Signal Transduction EDAT- 2020/07/17 06:00 MHDA- 2020/09/09 06:00 CRDT- 2020/07/17 06:00 PHST- 2019/10/08 00:00 [received] PHST- 2020/06/04 00:00 [accepted] PHST- 2020/07/17 06:00 [pubmed] PHST- 2020/09/09 06:00 [medline] PHST- 2020/07/17 06:00 [entrez] AID - 10.1038/s41586-020-2501-8 [pii] AID - 10.1038/s41586-020-2501-8 [doi] PST - ppublish SO - Nature. 2020 Aug;584(7819):109-114. doi: 10.1038/s41586-020-2501-8. Epub 2020 Jul 15.