PMID- 32671098
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 7
DP  - 2020
TI  - Antibodies and Immunity During Kawasaki Disease.
PG  - 94
LID - 10.3389/fcvm.2020.00094 [doi]
LID - 94
AB  - The cause of Kawasaki disease (KD), the leading cause of acquired heart disease 
      in children, is currently unknown. Epidemiology studies support that an 
      infectious disease is involved in at least starting the inflammatory cascade set 
      off during KD. Clues from epidemiology support that humoral immunity can have a 
      protective effect. However, the role of the immune system, particularly of B 
      cells and antibodies, in pathogenesis of KD is still unclear. Intravenous 
      immunoglobulin (IVIG) and other therapies targeted at modulating inflammation can 
      prevent development of coronary aneurysms. A number of autoantibody responses 
      have been reported in children with KD and antibodies have been generated from 
      aneurysmal plasma cell infiltrates. Recent reports show that children with KD 
      have similar plasmablast responses as other children with infectious diseases, 
      further supporting an infectious starting point. As ongoing studies are 
      attempting to identify the etiology of KD through study of antibody responses, we 
      sought to review the role of humoral immunity in KD pathogenesis, treatment, and 
      recovery.
CI  - Copyright (c) 2020 Hicar.
FAU - Hicar, Mark Daniel
AU  - Hicar MD
AD  - University at Buffalo, Buffalo, NY, United States.
AD  - John R. Oishei Children's Hospital, Buffalo, NY, United States.
AD  - Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, 
      University at Buffalo, Buffalo, NY, United States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200528
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC7326051
OTO - NOTNLM
OT  - B cells
OT  - antibodies-monoclonal
OT  - immunoglobulin intravenous
OT  - kawasaki disease
OT  - plasmablast
EDAT- 2020/07/17 06:00
MHDA- 2020/07/17 06:01
PMCR- 2020/01/01
CRDT- 2020/07/17 06:00
PHST- 2019/07/08 00:00 [received]
PHST- 2020/04/30 00:00 [accepted]
PHST- 2020/07/17 06:00 [entrez]
PHST- 2020/07/17 06:00 [pubmed]
PHST- 2020/07/17 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2020.00094 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2020 May 28;7:94. doi: 10.3389/fcvm.2020.00094. eCollection 
      2020.