PMID- 32672206
OWN - NLM
STAT- MEDLINE
DCOM- 20210528
LR  - 20210528
IS  - 1094-4087 (Electronic)
IS  - 1094-4087 (Linking)
VI  - 28
IP  - 13
DP  - 2020 Jun 22
TI  - High-robustness intravascular photoacoustic endoscope with a hermetically sealed 
      opto-sono capsule.
PG  - 19255-19269
LID - 10.1364/OE.394781 [doi]
AB  - The prevailing open-structure intravascular photoacoustic (IVPA) endoscope emits 
      a gradually deformed laser beam with exposed optical or acoustical components 
      bearing pollution and damage in arterial lumen. Deformed laser beam scanning, 
      which causes a low excitation efficiency and serious deterioration of the 
      transverse resolution, is a current big obstacle to the application of 
      photoacoustic endoscopy in intravascular imaging. Hence, the stable and reliable 
      IVPA endoscope is indispensable. In this letter, we designed a high-robustness 
      intravascular photoacoustic (HR-IVPA) endoscope with a hermetically sealed 
      opto-sono capsule. The distal end of the opto-sono capsule was integrated with 
      miniaturized optics, including a customized C-Lens and a customized 
      total-reflection prism (TRP). The TRP was first applied to a side-viewing IVPA 
      endoscope, featuring a high-throughput energy coupling efficiency of 90% and a 
      cut-off free damage threshold. The optical path structure of the endoscope, 
      optimized using optical simulation tools, overcame the ambiguous focus shift 
      caused by chromatic dispersion and achieved a waist size of 20 microm as well as a 
      focus depth of 4 mm in water at the wavelength of 1200 nm. The mass phantom 
      experiments demonstrated that the HR-IVPA endoscope afforded repeatable IVPA 
      images with a relatively constant signal-to-noise ratio (SNR) of about  approximately 41.8 dB 
      and a transverse resolution of about  approximately 23 microm. The imaging experiments of the stent 
      and lipid further demonstrated the robustness and validated the imaging ability 
      of the HR-IVPA endoscope, which opens a new avenue for improving the endoscopic 
      imaging capability, strengthening the credible detection of atherosclerotic 
      cardiovascular disease.
FAU - Wen, Xue
AU  - Wen X
FAU - Lei, Peng
AU  - Lei P
FAU - Xiong, Kedi
AU  - Xiong K
FAU - Zhang, Pengfei
AU  - Zhang P
FAU - Yang, Sihua
AU  - Yang S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Opt Express
JT  - Optics express
JID - 101137103
SB  - IM
MH  - *Endoscopes
MH  - Equipment Design
MH  - Humans
MH  - *Phantoms, Imaging
MH  - Photoacoustic Techniques/*instrumentation
MH  - Plaque, Atherosclerotic/diagnostic imaging
MH  - Stents
MH  - Ultrasonography, Interventional/*methods
EDAT- 2020/07/17 06:00
MHDA- 2021/05/29 06:00
CRDT- 2020/07/17 06:00
PHST- 2020/07/17 06:00 [entrez]
PHST- 2020/07/17 06:00 [pubmed]
PHST- 2021/05/29 06:00 [medline]
AID - 432673 [pii]
AID - 10.1364/OE.394781 [doi]
PST - ppublish
SO  - Opt Express. 2020 Jun 22;28(13):19255-19269. doi: 10.1364/OE.394781.