PMID- 32674292
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 9
IP  - 7
DP  - 2020 Jul 14
TI  - Clinical Characterization of the Frequent Exacerbator Phenotype in Asthma.
LID - 10.3390/jcm9072226 [doi]
LID - 2226
AB  - BACKGROUND: Asthma exacerbation is episodic worsening of respiratory symptoms in 
      conjunction with the deterioration of lung function, which may occur 
      independently from the asthma severity hampering asthmatics' quality of life. 
      This study aimed to characterize the patient phenotype more prone to asthma 
      exacerbation (oral corticosteroid burst >/=2 per year) to allow the proper 
      identification of such patients. METHODS: This real-life, observational, 
      cross-sectional study evaluated 464 asthmatic patients stratified according to 
      the asthma exacerbations experienced in the previous year. Clinical, functional, 
      and blood parameters were retrieved from chart data and were representative of 
      patients in stable conditions. RESULTS: The frequent asthma exacerbator was more 
      commonly female, suffered from chronic rhinosinusitis with nasal polyposis, had 
      reduced lung function and peripheral oxygen saturation, and had increased daily 
      activity limitations. These patients often had severe asthma and more frequently 
      needed hospitalization in their lives. Furthermore, the frequent asthma 
      exacerbator had higher concentrations of serum immunoglobulin E (IgE) and exhaled 
      nitric oxide with cut-off risk values of 107.5 kU/L (OR = 4.1) and 43.35 ppb (OR 
      = 3.8), respectively. CONCLUSIONS: This study illustrates the clinical features 
      of the frequent asthma exacerbator phenotype. Nevertheless, serum IgE and exhaled 
      nitric oxide could allow the identification of this phenotype and the 
      establishment of an appropriate therapeutic approach.
FAU - Sprio, Andrea Elio
AU  - Sprio AE
AUID- ORCID: 0000-0001-5891-871X
AD  - Department of Clinical and Biological Sciences, University of Turin, San Luigi 
      Gonzaga University Hospital, Orbassano, 10043 Turin, Italy.
FAU - Carriero, Vitina
AU  - Carriero V
AD  - Department of Clinical and Biological Sciences, University of Turin, San Luigi 
      Gonzaga University Hospital, Orbassano, 10043 Turin, Italy.
FAU - Levra, Stefano
AU  - Levra S
AD  - Department of Clinical and Biological Sciences, University of Turin, San Luigi 
      Gonzaga University Hospital, Orbassano, 10043 Turin, Italy.
FAU - Botto, Carlotta
AU  - Botto C
AD  - Department of Clinical and Biological Sciences, University of Turin, San Luigi 
      Gonzaga University Hospital, Orbassano, 10043 Turin, Italy.
FAU - Bertolini, Francesca
AU  - Bertolini F
AD  - Department of Clinical and Biological Sciences, University of Turin, San Luigi 
      Gonzaga University Hospital, Orbassano, 10043 Turin, Italy.
FAU - Di Stefano, Antonino
AU  - Di Stefano A
AUID- ORCID: 0000-0003-3479-0875
AD  - Department of Pneumology and Laboratory of Cytoimmunopathology of the Heart and 
      Lung, Istituti Clinici Scientifici Maugeri SpA, IRCCS, Veruno, 28010 Novara, 
      Italy.
FAU - Maniscalco, Mauro
AU  - Maniscalco M
AUID- ORCID: 0000-0001-6751-9921
AD  - Pulmonary Rehabilitation Unit, Istituti Clinici Scientifici Maugeri SpA, IRCCS, 
      Telese Terme, 82037 Benevento, Italy.
FAU - Ciprandi, Giorgio
AU  - Ciprandi G
AUID- ORCID: 0000-0001-7016-8421
AD  - Allergy Clinic, Casa di Cura Villa Montallegro, 16145 Genoa, Italy.
FAU - Ricciardolo, Fabio Luigi Massimo
AU  - Ricciardolo FLM
AD  - Department of Clinical and Biological Sciences, University of Turin, San Luigi 
      Gonzaga University Hospital, Orbassano, 10043 Turin, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200714
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7408982
OTO - NOTNLM
OT  - IgE
OT  - airway obstruction
OT  - asthma
OT  - nasal polyps
OT  - nitric oxide
COIS- The authors declare that no conflicts of interest exist.
EDAT- 2020/07/18 06:00
MHDA- 2020/07/18 06:01
PMCR- 2020/07/14
CRDT- 2020/07/18 06:00
PHST- 2020/06/15 00:00 [received]
PHST- 2020/07/05 00:00 [revised]
PHST- 2020/07/10 00:00 [accepted]
PHST- 2020/07/18 06:00 [entrez]
PHST- 2020/07/18 06:00 [pubmed]
PHST- 2020/07/18 06:01 [medline]
PHST- 2020/07/14 00:00 [pmc-release]
AID - jcm9072226 [pii]
AID - jcm-09-02226 [pii]
AID - 10.3390/jcm9072226 [doi]
PST - epublish
SO  - J Clin Med. 2020 Jul 14;9(7):2226. doi: 10.3390/jcm9072226.