PMID- 32675224
OWN - NLM
STAT- MEDLINE
DCOM- 20210928
LR  - 20230615
IS  - 1592-8721 (Electronic)
IS  - 0390-6078 (Print)
IS  - 0390-6078 (Linking)
VI  - 106
IP  - 8
DP  - 2021 Aug 1
TI  - Genetic variation near CXCL12 is associated with susceptibility to HIV-related 
      non-Hodgkin lymphoma.
PG  - 2233-2241
LID - 10.3324/haematol.2020.247023 [doi]
AB  - Human immunodeficiency virus (HIV) infection is associated with an increased risk 
      of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral 
      treatment, HIV-infected individuals remain at higher risk of developing NHL 
      compared to the general population. To identify potential genetic risk loci, we 
      performed case-control genome-wide association studies and a meta-analysis across 
      three cohorts of HIV+ patients of European ancestry, including a total of 278 
      cases and 1924 matched controls. We observed a significant association with NHL 
      susceptibility in the C-X-C motif chemokine ligand 12 (CXCL12) region on 
      chromosome 10. A fine mapping analysis identified rs7919208 as the most likely 
      causal variant (P = 4.77e-11), with the G>A polymorphism creating a new 
      transcription factor binding site for BATF and JUND. These results suggest a 
      modulatory role of CXCL12 regulation in the increased susceptibility to NHL 
      observed in the HIV-infected population.
FAU - Thorball, Christian W
AU  - Thorball CW
AD  - Ecole Polytechnique Federale de Lausanne, Swiss Institute of Bioinformatics, 
      Lausanne, Switzerland.
FAU - Oudot-Mellakh, Tiphaine
AU  - Oudot-Mellakh T
AD  - Centre de genetique moleculaire et chromosomique, GH La Pitie Salpetriere, Paris, 
      France.
FAU - Ehsan, Nava
AU  - Ehsan N
AD  - Scripps Research Translational Institute, La Jolla, CA, USA.
FAU - Hammer, Christian
AU  - Hammer C
AD  - Dept. of Cancer Immunology and Human Genetics, Genentech, South San Francisco, 
      CA, USA.
FAU - Santoni, Federico A
AU  - Santoni FA
AD  - Dept. of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, 
      Switzerland.
FAU - Niay, Jonathan
AU  - Niay J
AD  - Centre de genetique moleculaire et chromosomique, GH La Pitie Salpetriere, Paris, 
      France.
FAU - Costagliola, Dominique
AU  - Costagliola D
AD  - Sorbonne Universite, Institut Pierre Louis d'epidemiologie, Paris, France.
FAU - Goujard, Cecile
AU  - Goujard C
AD  - Paris-Sud University and Bicetre Hospital, Le Kremlin-Bicetre, France.
FAU - Meyer, Laurence
AU  - Meyer L
AD  - Paris-Sud University, Le Kremlin-Bicetre, France.
FAU - Wang, Sophia S
AU  - Wang SS
AD  - Division of Health Analytics, City of Hope Beckman Research Institute, Duarte, 
      CA, USA.
FAU - Hussain, Shehnaz K
AU  - Hussain SK
AD  - Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - Theodorou, Ioannis
AU  - Theodorou I
AD  - Centre de genetique moleculaire et chromosomique, GH La Pitie Salpetriere, Paris, 
      France.
FAU - Cavassini, Matthias
AU  - Cavassini M
AD  - Service of Infectious Diseases, Lausanne University Hospital and University of 
      Lausanne, Switzerland.
FAU - Rauch, Andri
AU  - Rauch A
AD  - Dept. of Infectious Diseases, Bern University Hospital, University of Bern, 
      Switzerland.
FAU - Battegay, Manuel
AU  - Battegay M
AD  - Dept. of Infectious Diseases and Hospital Epidemiology, University Hospital 
      Basel, Switzerland.
FAU - Hoffmann, Matthias
AU  - Hoffmann M
AD  - Division of Infectious Diseases and Hospital Epidemiology, Kantonsspital Olten, 
      Switzerland.
FAU - Schmid, Patrick
AU  - Schmid P
AD  - Division of Infectious Diseases, Cantonal Hospital of St. Gallen, St. Gallen, 
      Switzerland.
FAU - Bernasconi, Enos
AU  - Bernasconi E
AD  - Division of Infectious Diseases, Regional Hospital of Lugano, Lugano, 
      Switzerland.
FAU - Gunthard, Huldrych F
AU  - Gunthard HF
AD  - Institute of Medical Virology, University of Zurich, Switzerland.
FAU - Mohammadi, Pejman
AU  - Mohammadi P
AD  - Scripps Research Translational Institute, La Jolla, CA, USA.
FAU - McLaren, Paul J
AU  - McLaren PJ
AD  - JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, 
      Winnipeg, Canada.
FAU - Rabkin, Charles S
AU  - Rabkin CS
AD  - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 
      Rockville, MD, USA.
FAU - Besson, Caroline
AU  - Besson C
AD  - Department of Hematology and Oncology, Hospital of Versailles, Le Chesnay, 
      France.
FAU - Fellay, Jacques
AU  - Fellay J
AD  - Ecole Polytechnique Federale de Lausanne and University of Lausanne, Switzerland.
LA  - eng
GR  - R01 GM140287/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20210801
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - 0 (Anti-Retroviral Agents)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
SB  - IM
MH  - Anti-Retroviral Agents/therapeutic use
MH  - Case-Control Studies
MH  - Chemokine CXCL12
MH  - Genome-Wide Association Study
MH  - *HIV Infections/complications/drug therapy/genetics
MH  - Humans
MH  - *Lymphoma, AIDS-Related/drug therapy
MH  - *Lymphoma, Non-Hodgkin/drug therapy/genetics
MH  - Polymorphism, Genetic
PMC - PMC8327743
EDAT- 2020/07/18 06:00
MHDA- 2021/09/29 06:00
PMCR- 2020/07/16
CRDT- 2020/07/18 06:00
PHST- 2020/01/09 00:00 [received]
PHST- 2020/07/18 06:00 [pubmed]
PHST- 2021/09/29 06:00 [medline]
PHST- 2020/07/18 06:00 [entrez]
PHST- 2020/07/16 00:00 [pmc-release]
AID - haematol.2020.247023 [pii]
AID - 10.3324/haematol.2020.247023 [doi]
PST - epublish
SO  - Haematologica. 2021 Aug 1;106(8):2233-2241. doi: 10.3324/haematol.2020.247023.