PMID- 32675288
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 2332-7812 (Electronic)
IS  - 2332-7812 (Linking)
VI  - 7
IP  - 5
DP  - 2020 Sep
TI  - Genetic determinants of the humoral immune response in MS.
LID - 10.1212/NXI.0000000000000827 [doi]
LID - e827
AB  - OBJECTIVE: In this observational study, we investigated the impact of genetic 
      factors at the immunoglobulin heavy chain constant locus on chromosome 14 and the 
      major histocompatibility complex region on intrathecal immunoglobulin G, A, and M 
      levels as well as on B cells and plasmablasts in the CSF and blood of patients 
      with multiple sclerosis (MS). METHODS: Using regression analyses, we tested 
      genetic variants on chromosome 14 and imputed human leukocyte antigen (HLA) 
      alleles for associations with intrathecal immunoglobulins in 1,279 patients with 
      MS or clinically isolated syndrome and with blood and CSF B cells and 
      plasmablasts in 301 and 348 patients, respectively. RESULTS: The minor alleles of 
      variants on chromosome 14 were associated with higher intrathecal immunoglobulin 
      G levels (beta = 0.58 [0.47 to 0.68], lowest adjusted p = 2.32 x 10(-23)), and lower 
      intrathecal immunoglobulin M (beta = -0.56 [-0.67 to -0.46], p = 2.06 x 10(-24)) and 
      A (beta = -0.42 [-0.54 to -0.31], p = 7.48 x 10(-11)) levels. Alleles from the 
      HLA-B*07:02-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype were associated with 
      higher (lowest p = 2.14 x 10(-7)) and HLA-B*44:02 with lower (beta = -0.35 [-0.54 to 
      -0.17], p = 1.38 x 10(-2)) immunoglobulin G levels. Of interest, different HLA 
      alleles were associated with lower intrathecal immunoglobulin M (HLA-C*02:02, beta = 
      -0.45 [-0.61 to -0.28], p = 1.01 x 10(-5)) and higher immunoglobulin A levels 
      (HLA-DQA1*01:03-DQB1*06:03-DRB1*13:01 haplotype, beta = 0.40 [0.21 to 0.60], p = 
      4.46 x 10(-3)). The impact of HLA alleles on intrathecal immunoglobulin G and M 
      levels could mostly be explained by associations with CSF B cells and 
      plasmablasts. CONCLUSION: Although some HLA alleles seem to primarily drive the 
      extent of humoral immune responses in the CNS by increasing CSF B cells and 
      plasmablasts, genetic variants at the immunoglobulin heavy chain constant locus 
      might regulate intrathecal immunoglobulins levels via different mechanisms.
CI  - Copyright (c) 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American Academy of Neurology.
FAU - Gasperi, Christiane
AU  - Gasperi C
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Andlauer, Till F M
AU  - Andlauer TFM
AUID- ORCID: 0000-0002-2917-5889
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Keating, Ana
AU  - Keating A
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Knier, Benjamin
AU  - Knier B
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Klein, Ana
AU  - Klein A
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Pernpeintner, Verena
AU  - Pernpeintner V
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Lichtner, Peter
AU  - Lichtner P
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Gold, Ralf
AU  - Gold R
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Zipp, Frauke
AU  - Zipp F
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Then Bergh, Florian
AU  - Then Bergh F
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Stangel, Martin
AU  - Stangel M
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Tumani, Hayrettin
AU  - Tumani H
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Wildemann, Brigitte
AU  - Wildemann B
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Wiendl, Heinz
AU  - Wiendl H
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Bayas, Antonios
AU  - Bayas A
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Kumpfel, Tania
AU  - Kumpfel T
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Zettl, Uwe K
AU  - Zettl UK
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Linker, Ralf A
AU  - Linker RA
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Ziemann, Ulf
AU  - Ziemann U
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Knop, Matthias
AU  - Knop M
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Warnke, Clemens
AU  - Warnke C
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Friese, Manuel A
AU  - Friese MA
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Paul, Friedemann
AU  - Paul F
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Tackenberg, Bjorn
AU  - Tackenberg B
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Berthele, Achim
AU  - Berthele A
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.
FAU - Hemmer, Bernhard
AU  - Hemmer B
AUID- ORCID: 0000-0001-5985-6784
AD  - From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, 
      V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical 
      University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum 
      Munchen, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, 
      Ruhr-University Bochum; Department of Neurology, Focus Program Translational 
      Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main 
      Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes 
      Gutenberg University Mainz; Department of Neurology and Translational Center for 
      Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology 
      and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, 
      Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology 
      Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital 
      Heidelberg; Department of Neurology (H.W.), University of Munster; Department of 
      Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical 
      Neuroimmunology (T.K.), University Hospital and Biomedical Center, 
      Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), 
      Neuroimmunological Section, University of Rostock; Department of Neurology 
      (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), 
      University of Regensburg; Department of Neurology & Stroke and Hertie-Institute 
      for Clinical Brain Research (U.Z.), Eberhard-Karls-Universitat Tubingen; Max 
      Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), 
      Medical Faculty, Heinrich Heine University, Dusseldorf; Department of Neurology 
      (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple 
      Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; 
      NeuroCure Clinical Research Center (F.P.), Charite-Universitatsmedizin Berlin, 
      Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin; 
      Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), 
      Max Delbruck Center for Molecular Medicine and Charite-Universitatsmedizin 
      Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and 
      Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany. hemmer@tum.de.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200716
PL  - United States
TA  - Neurol Neuroimmunol Neuroinflamm
JT  - Neurology(R) neuroimmunology & neuroinflammation
JID - 101636388
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Cohort Studies
MH  - Female
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Immunity, Humoral/*genetics
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/blood/cerebrospinal fluid/*genetics/*immunology
PMC - PMC7371373
EDAT- 2020/07/18 06:00
MHDA- 2021/09/14 06:00
PMCR- 2020/07/16
CRDT- 2020/07/18 06:00
PHST- 2020/02/28 00:00 [received]
PHST- 2020/05/26 00:00 [accepted]
PHST- 2020/07/18 06:00 [entrez]
PHST- 2020/07/18 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2020/07/16 00:00 [pmc-release]
AID - 7/5/e827 [pii]
AID - NEURIMMINFL2020027938 [pii]
AID - 10.1212/NXI.0000000000000827 [doi]
PST - epublish
SO  - Neurol Neuroimmunol Neuroinflamm. 2020 Jul 16;7(5):e827. doi: 
      10.1212/NXI.0000000000000827. Print 2020 Sep.