PMID- 32676938
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 199
IP  - 5
DP  - 2021 May
TI  - Factors Influencing Selenium Concentration in Community-Dwelling Patients with 
      Type 2 Diabetes Mellitus.
PG  - 1657-1663
LID - 10.1007/s12011-020-02283-9 [doi]
AB  - Selenium (Se) plays an important role in the pathogenesis of diabetes, and which 
      factors affecting Se concentration in patients with type 2 diabetes mellitus 
      (T2DM) are unknown. This study aimed to explore the factors influencing Se 
      concentration in community-dwelling individuals with T2DM. A total of 176 
      patients with T2DM were involved, and their general information was collected 
      through a self-designed questionnaire. Venous blood samples and hair samples were 
      collected to detect Se concentration and biochemical parameters. Multiple linear 
      regression and binary logistic regression analysis were used to analyze the 
      factors influencing Se concentration in patients with T2DM. The factors 
      influencing selenoprotein P concentration in patients with T2DM included alkaline 
      phosphatase (beta = - 1.373; 95% CI: 0.087-0.736; P = 0.012), systolic blood 
      pressure (SBP; beta = - 0.047; 95% CI: 0.930-0.978; P < 0.001), the duration of T2DM 
      (beta = - 0.074; 95% CI: 0.877-0.983; P = 0.011), and clinical complications 
      (beta = 1.237; 95% CI: 1.465-8.109; P = 0.005). The factors influencing glutathione 
      peroxidase activity in patients with T2DM were creatinine (CREA; beta = - 0.378; 
      P < 0.001), uric acid (beta = - 0.069; P = 0.009), body mass index (beta = - 2.177; 
      P = 0.002), SBP (beta = - 0.275; P = 0.031), and medical payment (beta = 29.160; 
      P < 0.001). The factors influencing serum Se concentration in patients with T2DM 
      were albumin (beta = - 1.391; 95% CI: 0.065-0.959; P = 0.043) and CREA (beta = - 1.482; 
      95% CI: 0.072-0.718; P = 0.012). The factors influencing hair Se concentration in 
      patients with T2DM were smoking (beta = - 1.151; 95% CI: 0.133-0.755; P = 0.010), 
      drinking (beta = 1.366; 95% CI: 1.191-12.909; P = 0.025), and hair dyeing 
      (beta = - 1.113; 95% CI: 0.124-0.867; P = 0.025). In conclusion, the Se 
      concentration in patients with T2DM was mainly affected by liver and renal 
      function. When liver and/or renal function was impaired, the Se concentration in 
      patients with T2DM was decreased.
FAU - Xi, Jing
AU  - Xi J
AD  - School of Nursing, Medical College, Soochow University, No.1 Shizi Street, 
      Suzhou, 215006, China.
FAU - Zhang, Qianqian
AU  - Zhang Q
AD  - School of Nursing, Medical College, Soochow University, No.1 Shizi Street, 
      Suzhou, 215006, China.
AD  - The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Research Center, Soochow Setek Biotechnology Co., Ltd, Suzhou, China.
FAU - Guo, Renmei
AU  - Guo R
AD  - Research Center, Soochow Setek Biotechnology Co., Ltd, Suzhou, China.
FAU - Wang, Li
AU  - Wang L
AD  - School of Nursing, Medical College, Soochow University, No.1 Shizi Street, 
      Suzhou, 215006, China. li-wang-1@suda.edu.cn.
LA  - eng
GR  - BY2018179/Industry University Cooperation Research Project in Jiangsu Province/
PT  - Journal Article
DEP - 20200716
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Selenoprotein P)
RN  - H6241UJ22B (Selenium)
SB  - IM
MH  - Body Mass Index
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - Independent Living
MH  - *Selenium
MH  - Selenoprotein P
OTO - NOTNLM
OT  - Influencing factors
OT  - Selenium
OT  - Type 2 diabetes mellitus
EDAT- 2020/07/18 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/07/18 06:00
PHST- 2020/04/25 00:00 [received]
PHST- 2020/07/06 00:00 [accepted]
PHST- 2020/07/18 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/07/18 06:00 [entrez]
AID - 10.1007/s12011-020-02283-9 [pii]
AID - 10.1007/s12011-020-02283-9 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2021 May;199(5):1657-1663. doi: 10.1007/s12011-020-02283-9. 
      Epub 2020 Jul 16.