PMID- 32677021
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2509-8020 (Electronic)
IS  - 2509-8020 (Linking)
VI  - 4
IP  - 1
DP  - 2020 Jul 16
TI  - Patient-reported quality-of-life outcomes in relation to provider-assessed 
      adverse events during head and neck radiotherapy.
PG  - 60
LID - 10.1186/s41687-020-00227-4 [doi]
LID - 60
AB  - PURPOSE: To assess the relationship between patient-reported quality-of-life 
      (QOL) outcomes and provider-assessed adverse events (AEs) during head-and-neck 
      (H&N) radiotherapy (RT). METHODS: Sixty-five patients undergoing H&N RT 
      prospectively completed 12-domain linear analogue self-assessments (LASA) at 
      baseline, before biweekly appointments, and at last week of RT. At the same time 
      points, provider-assessed AEs were graded using Common Terminology Criteria for 
      Adverse Events v4.0. LASA scores were stratified by maximum-grade AE and analyzed 
      using Kruskal-Wallis methodology. Agreement between LASA scores and maximum-grade 
      AE was assessed using Bland-Altman analysis. RESULTS: Patient-reported QOL 
      outcomes showed clinically meaningful decreases in most domains, predominantly 
      fatigue (77.8% of patients), social activity (75.4%), and overall QOL (74.2%). 
      Provider-assessed AEs showed 100% grade 2 AE, 35.4% grade 3 AE, and 3.1% grade 4 
      AE. At baseline, patients with higher grade AEs reported worse physical 
      well-being (WB) (P = .04). At week 1, the following QOL domains were worse for 
      patients with higher grade AEs: overall QOL (P = .03), mental WB (P = .02), and 
      physical WB (P = .03). Bland-Altman analysis showed that QOL scores were 
      relatively worse than AE burden at baseline and relatively better at RT 
      completion. CONCLUSIONS: Worse QOL was associated with higher-grade AEs at 
      baseline and early in RT. The impact of AEs on QOL appears to lessen with time. 
      Patient-reported QOL outcomes and provider-assessed AEs provide complementary 
      information.
FAU - Niska, Joshua R
AU  - Niska JR
AD  - Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA.
FAU - Thorpe, Cameron S
AU  - Thorpe CS
AD  - Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA.
FAU - Halyard, Michele Y
AU  - Halyard MY
AUID- ORCID: 0000-0003-0998-4600
AD  - Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA. 
      mhalyard@mayo.edu.
FAU - Tan, Angelina D
AU  - Tan AD
AD  - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, 
      Minnesota, USA.
FAU - Atherton, Pamela J
AU  - Atherton PJ
AD  - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, 
      Minnesota, USA.
FAU - Dueck, Amylou C
AU  - Dueck AC
AD  - Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona, USA.
FAU - Patel, Samir H
AU  - Patel SH
AD  - Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA.
FAU - Sloan, Jeff A
AU  - Sloan JA
AD  - Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, 
      Minnesota, USA.
LA  - eng
PT  - Journal Article
DEP - 20200716
PL  - Germany
TA  - J Patient Rep Outcomes
JT  - Journal of patient-reported outcomes
JID - 101722688
PMC - PMC7364694
OTO - NOTNLM
OT  - Cancer
OT  - Head and neck neoplasms
OT  - Patient reported outcome measures
OT  - QOL
OT  - Quality-of-life
OT  - RT
OT  - Radiation oncology
OT  - Radiation therapy
OT  - Radiotherapy
COIS- Actual or potential conflicts of interest do not exist.
EDAT- 2020/07/18 06:00
MHDA- 2020/07/18 06:01
PMCR- 2020/07/16
CRDT- 2020/07/18 06:00
PHST- 2019/12/18 00:00 [received]
PHST- 2020/07/05 00:00 [accepted]
PHST- 2020/07/18 06:00 [entrez]
PHST- 2020/07/18 06:00 [pubmed]
PHST- 2020/07/18 06:01 [medline]
PHST- 2020/07/16 00:00 [pmc-release]
AID - 10.1186/s41687-020-00227-4 [pii]
AID - 227 [pii]
AID - 10.1186/s41687-020-00227-4 [doi]
PST - epublish
SO  - J Patient Rep Outcomes. 2020 Jul 16;4(1):60. doi: 10.1186/s41687-020-00227-4.