PMID- 32677382
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20201109
IS  - 2005-8330 (Electronic)
IS  - 1229-6929 (Print)
IS  - 1229-6929 (Linking)
VI  - 21
IP  - 8
DP  - 2020 Aug
TI  - Quantitative T1 Mapping for Detecting Microvascular Obstruction in Reperfused 
      Acute Myocardial Infarction: Comparison with Late Gadolinium Enhancement Imaging.
PG  - 978-986
LID - 10.3348/kjr.2019.0736 [doi]
AB  - OBJECTIVE: To compare native and post-contrast T1 mapping with late gadolinium 
      enhancement (LGE) imaging for detecting and measuring the microvascular 
      obstruction (MVO) area in reperfused acute myocardial infarction (MI). MATERIALS 
      AND METHODS: This study included 20 patients with acute MI who had undergone 1.5T 
      cardiovascular magnetic resonance imaging (CMR) after reperfusion therapy. CMR 
      included cine imaging, LGE, and T1 mapping (modified look-locker inversion 
      recovery). MI size was calculated from LGE by full-width at half-maximum 
      technique. MVO was defined as an area with low signal intensity (LGE) or as a 
      region of visually distinguishable T1 values (T1 maps) within infarcted 
      myocardium. Regional T1 values were measured in MVO, infarcted, and remote 
      myocardium on T1 maps. MVO area was measured on and compared among LGE, native, 
      and post-contrast T1 maps. RESULTS: The mean MI size was 27.1 +/- 9.7% of the left 
      ventricular mass. Of the 20 identified MVOs, 18 (90%) were detected on native T1 
      maps, while 10 (50%) were recognized on post-contrast T1 maps. The mean native T1 
      values of MVO, infarcted, and remote myocardium were 1013.5 +/- 58.5, 1240.9 +/- 55.8 
      (p < 0.001), and 1062.2 +/- 55.8 ms (p = 0.169), respectively, while the mean 
      post-contrast T1 values were 466.7 +/- 26.8, 399.1 +/- 21.3, and 585.2 +/- 21.3 ms, 
      respectively (p < 0.001). The mean MVO areas on LGE, native, and post-contrast T1 
      maps were 134.1 +/- 81.2, 133.7 +/- 80.4, and 117.1 +/- 53.3 mm(2), respectively. The 
      median (interquartile range) MVO areas on LGE, native, and post-contrast T1 maps 
      were 128.0 (58.1-215.4), 110.5 (67.7-227.9), and 143.0 (76.7-155.3) mm(2), 
      respectively (p = 0.002). Concordance correlation coefficients for the MVO area 
      between LGE and native T1 maps, LGE and post-contrast T1 maps, and native and 
      post-contrast T1 maps were 0.770, 0.375, and 0.565, respectively. CONCLUSION: MVO 
      areas were accurately delineated on native T1 maps and showed high concordance 
      with the areas measured on LGE. However, post-contrast T1 maps had low detection 
      rates and underestimated MVO areas. Collectively, native T1 mapping is a useful 
      tool for detecting MVO within the infarcted myocardium.
CI  - Copyright (c) 2020 The Korean Society of Radiology.
FAU - Shin, Jae Min
AU  - Shin JM
AUID- ORCID: 0000-0003-4549-3518
AD  - Department of Radiology and the Research Institute of Radiological Science, 
      Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
FAU - Choi, Eui Young
AU  - Choi EY
AUID- ORCID: 0000-0003-3732-0190
AD  - Division of Cardiology, Heart Center, Gangnam Severance Hospital, Yonsei 
      University College of Medicine, Seoul, Korea.
FAU - Park, Chul Hwan
AU  - Park CH
AUID- ORCID: 0000-0002-0004-9475
AD  - Department of Radiology and the Research Institute of Radiological Science, 
      Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
FAU - Han, Kyunghwa
AU  - Han K
AUID- ORCID: 0000-0002-5687-7237
AD  - Department of Radiology and the Research Institute of Radiological Science, 
      Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
FAU - Kim, Tae Hoon
AU  - Kim TH
AUID- ORCID: 0000-0003-3598-2529
AD  - Department of Radiology and the Research Institute of Radiological Science, 
      Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. 
      thkim1@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Korean J Radiol
JT  - Korean journal of radiology
JID - 100956096
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Contrast Media
MH  - Female
MH  - Gadolinium
MH  - Heart/*diagnostic imaging
MH  - Humans
MH  - Image Enhancement
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnostic imaging/*pathology
MH  - Myocardial Reperfusion Injury/*diagnostic imaging/pathology
MH  - Myocardium/pathology
PMC - PMC7369203
OTO - NOTNLM
OT  - Cardiovascular magnetic resonance imaging
OT  - Late gadolinium enhancing imaging
OT  - Microvascular obstruction
OT  - Myocardial infarction
OT  - T1 mapping
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2020/07/18 06:00
MHDA- 2020/11/11 06:00
PMCR- 2020/08/01
CRDT- 2020/07/18 06:00
PHST- 2019/10/05 00:00 [received]
PHST- 2020/02/15 00:00 [revised]
PHST- 2020/03/05 00:00 [accepted]
PHST- 2020/07/18 06:00 [entrez]
PHST- 2020/07/18 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2020/08/01 00:00 [pmc-release]
AID - 21.978 [pii]
AID - 10.3348/kjr.2019.0736 [doi]
PST - ppublish
SO  - Korean J Radiol. 2020 Aug;21(8):978-986. doi: 10.3348/kjr.2019.0736.