PMID- 32677965
OWN - NLM
STAT- MEDLINE
DCOM- 20210503
LR  - 20210503
IS  - 2045-8118 (Electronic)
IS  - 2045-8118 (Linking)
VI  - 17
IP  - 1
DP  - 2020 Jul 16
TI  - Modeling blood-brain barrier pathology in cerebrovascular disease in vitro: 
      current and future paradigms.
PG  - 44
LID - 10.1186/s12987-020-00202-7 [doi]
LID - 44
AB  - The complexity of the blood-brain barrier (BBB) and neurovascular unit (NVU) was 
      and still is a challenge to bridge. A highly selective, restrictive and dynamic 
      barrier, formed at the interface of blood and brain, the BBB is a "gatekeeper" 
      and guardian of brain homeostasis and it also acts as a "sensor" of pathological 
      events in blood and brain. The majority of brain and cerebrovascular pathologies 
      are associated with BBB dysfunction, where changes at the BBB can lead to or 
      support disease development. Thus, an ultimate goal of BBB research is to develop 
      competent and highly translational models to understand mechanisms of BBB/NVU 
      pathology and enable discovery and development of therapeutic strategies to 
      improve vascular health and for the efficient delivery of drugs. This review 
      article focuses on the progress being made to model BBB injury in cerebrovascular 
      diseases in vitro.
FAU - Andjelkovic, Anuska V
AU  - Andjelkovic AV
AUID- ORCID: 0000-0001-8365-8016
AD  - Department of Pathology, University of Michigan Medical School, 7520 MSRB I, 1150 
      West Medical Center Dr, Ann Arbor, MI, 48109-5602, USA. anuskaa@med.umich.edu.
FAU - Stamatovic, Svetlana M
AU  - Stamatovic SM
AD  - Department of Pathology, University of Michigan Medical School, 7520 MSRB I, 1150 
      West Medical Center Dr, Ann Arbor, MI, 48109-5602, USA.
FAU - Phillips, Chelsea M
AU  - Phillips CM
AD  - Graduate Program in Neuroscience, University of Michigan Medical School, Ann 
      Arbor, MI, USA.
FAU - Martinez-Revollar, Gabriela
AU  - Martinez-Revollar G
AD  - Department of Pathology, University of Michigan Medical School, 7520 MSRB I, 1150 
      West Medical Center Dr, Ann Arbor, MI, 48109-5602, USA.
FAU - Keep, Richard F
AU  - Keep RF
AD  - Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI, 
      USA.
AD  - Department of Molecular Integrative Physiology, University of Michigan Medical 
      School, Ann Arbor, MI, USA.
LA  - eng
GR  - RF1 AG057928/AG/NIA NIH HHS/United States
GR  - RF1 AG064957/AG/NIA NIH HHS/United States
GR  - NS111205/NS/NINDS NIH HHS/United States
GR  - RFA057928/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20200716
PL  - England
TA  - Fluids Barriers CNS
JT  - Fluids and barriers of the CNS
JID - 101553157
SB  - IM
MH  - Astrocytes/*physiology
MH  - *Blood-Brain Barrier/immunology/pathology/physiopathology
MH  - *Cerebrovascular Disorders/immunology/pathology/physiopathology
MH  - Endothelial Cells/*physiology
MH  - Humans
MH  - *In Vitro Techniques
MH  - *Models, Neurological
MH  - Neurons/*physiology
MH  - Tight Junctions/*physiology
PMC - PMC7367394
OTO - NOTNLM
OT  - Blood-brain barrier
OT  - Brain vascular malformation
OT  - In vitro models
OT  - Neurovascular units
OT  - Stroke
OT  - Vascular dementia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. RFK is a co-editor in chief of Fluids Barriers CNS.
EDAT- 2020/07/18 06:00
MHDA- 2021/05/04 06:00
PMCR- 2020/07/16
CRDT- 2020/07/18 06:00
PHST- 2020/03/31 00:00 [received]
PHST- 2020/06/15 00:00 [accepted]
PHST- 2020/07/18 06:00 [entrez]
PHST- 2020/07/18 06:00 [pubmed]
PHST- 2021/05/04 06:00 [medline]
PHST- 2020/07/16 00:00 [pmc-release]
AID - 10.1186/s12987-020-00202-7 [pii]
AID - 202 [pii]
AID - 10.1186/s12987-020-00202-7 [doi]
PST - epublish
SO  - Fluids Barriers CNS. 2020 Jul 16;17(1):44. doi: 10.1186/s12987-020-00202-7.