PMID- 32678184
OWN - NLM
STAT- MEDLINE
DCOM- 20201221
LR  - 20210716
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jul 16
TI  - Analysis of the foveal microvasculature in sickle cell disease using swept-source 
      optical coherence tomography angiography.
PG  - 11795
LID - 10.1038/s41598-020-68625-8 [doi]
LID - 11795
AB  - Ischemic microangiopathy was clearly identified in sickle cell disease (SCD) 
      using fluorescein angiography. A prospective observational clinical study was 
      conducted to assess the foveal avascular zone (FAZ) area and explore perifoveal 
      microvasculature changes in the superficial (SCP) and deep (DCP) capillary plexus 
      using optical coherence tomography angiography (OCTA) and compare two 
      genotypes-HbS/HbS (HbSS) and HbS/HbC (HbSC)-to control. All consecutive patients 
      with electrophoretic confirmation of SCD were included. Swept-source OCTA scans 
      (Triton Plus, Topcon, Tokyo, Japan) with a 3 x 3-mm scanning area and ultra-wide 
      field (UWF) retinography (California, Optos, Fife, Scotland) were recorded for 
      all patients. For OCTA analysis, preset parameters were used to segment the SCP 
      and DCP. The FAZ area was manually assessed. The number of vascular branching 
      points was automatically assessed based on the vascular skeletonization using 
      ImageJ software. Eyes were staged based on Goldberg's classification of SCD 
      retinopathy (SCDR) using UWF imaging. Forty-six eyes of 24 patients were included 
      in the HbSS (n = 27) and HbSC (n = 19) groups and 16 eyes of 8 unaffected 
      patients in a control group. In the DCP, the FAZ was significantly larger in the 
      HbSC (p = 0.0001) and HbSS (p = 0.0004) groups compared to controls. The FAZ area 
      in the SCP, CRT and number of superficial vascular branching points did not 
      significantly differ between both genotypes. There were less branching points in 
      the HbSC (p = 0.034) and HbSS (p = 0.0014) groups than in controls. The Goldberg 
      stage was significantly higher in the HbSC group than in the HbSS group (2.21 vs. 
      1.22, p = 0.0062). OCTA provides useful information on macular microvasculature 
      and structural alterations associated with SCDR. Ischemic abnormalities are more 
      predominant in the DCP in case of SCDR and no difference was found between 
      genotypes of patients visually asymptomatic.
FAU - Mokrane, A
AU  - Mokrane A
AD  - Ophthalmology Department, Avicenne Hospital, 125 Rue de Stalingrad, 93000, 
      Bobigny, France.
FAU - Gazeau, G
AU  - Gazeau G
AD  - Clinical Research Unit, Avicenne Hospital, 125 Rue de Stalingrad, 93000, Bobigny, 
      France.
FAU - Levy, V
AU  - Levy V
AD  - Clinical Research Unit, Avicenne Hospital, 125 Rue de Stalingrad, 93000, Bobigny, 
      France.
FAU - Fajnkuchen, F
AU  - Fajnkuchen F
AD  - Ophthalmology Department, Avicenne Hospital, 125 Rue de Stalingrad, 93000, 
      Bobigny, France.
AD  - Ophthalmology Department, Centre D'Imagerie Et de Laser, 11 rue Antoine 
      Bourdelle, 75015, Paris, France.
FAU - Giocanti-Auregan, Audrey
AU  - Giocanti-Auregan A
AD  - Ophthalmology Department, Avicenne Hospital, 125 Rue de Stalingrad, 93000, 
      Bobigny, France. audreygiocanti@yahoo.fr.
LA  - eng
PT  - Journal Article
DEP - 20200716
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Anemia, Sickle Cell/complications/*pathology
MH  - Female
MH  - *Fluorescein Angiography/methods
MH  - Fovea Centralis/*blood supply/diagnostic imaging/*pathology
MH  - Humans
MH  - Male
MH  - Microvessels/diagnostic imaging/*pathology
MH  - Middle Aged
MH  - Retinal Diseases/*diagnostic imaging/etiology/*pathology
MH  - Severity of Illness Index
MH  - *Tomography, Optical Coherence/methods
MH  - Young Adult
PMC - PMC7366709
COIS- F. Fajnkuchen and A Giocanti-Auregan are consultant for Allergan, Bayer, Novartis 
      and Optos Plc. All other authors declare no competing interests.
EDAT- 2020/07/18 06:00
MHDA- 2020/12/22 06:00
PMCR- 2020/07/16
CRDT- 2020/07/18 06:00
PHST- 2019/07/04 00:00 [received]
PHST- 2020/06/19 00:00 [accepted]
PHST- 2020/07/18 06:00 [entrez]
PHST- 2020/07/18 06:00 [pubmed]
PHST- 2020/12/22 06:00 [medline]
PHST- 2020/07/16 00:00 [pmc-release]
AID - 10.1038/s41598-020-68625-8 [pii]
AID - 68625 [pii]
AID - 10.1038/s41598-020-68625-8 [doi]
PST - epublish
SO  - Sci Rep. 2020 Jul 16;10(1):11795. doi: 10.1038/s41598-020-68625-8.