PMID- 32678961
OWN - NLM
STAT- MEDLINE
DCOM- 20201022
LR  - 20220720
IS  - 1540-8191 (Electronic)
IS  - 0886-0440 (Print)
IS  - 0886-0440 (Linking)
VI  - 35
IP  - 10
DP  - 2020 Oct
TI  - Extracorporeal membrane oxygenation and COVID-19: The causes of failure.
PG  - 2838-2843
LID - 10.1111/jocs.14867 [doi]
AB  - INTRODUCTION: Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a 
      therapeutic strategy for the coronavirus disease 2019 (COVID-19) induced acute 
      respiratory distress syndrome (ARDS). There are inconclusive data in this regard 
      and causes of VV-ECMO failure are not yet understood well. CASE SERIES: Here, 
      seven patients with COVID-19-induced ARDS who underwent VV-ECMO introduced and 
      causes of VV-ECMO failure discussed. Medical records of seven COVID-19 patients 
      treated with VV-ECMO were retrospectively evaluated to determine the clinical 
      outcomes of VV-ECMO. Oxygenator failure occurred in four patients whom needed to 
      oxygenator replacement. Successful VV-ECMO decannulation was done in three 
      patients, however finally one patient survived. CONCLUSIONS: Hypercoagulability 
      state and oxygenator failure were the most main etiologies for VV-ECMO failure in 
      our study. All patients with COVID-19 undergoing VV-ECMO should be monitored for 
      such problems and highly specialized healthcare team should monitor the patients 
      during VV-ECMO.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Ahmadi, Zargham Hossein
AU  - Ahmadi ZH
AUID- ORCID: 0000-0002-2982-9950
AD  - Lung Transplantation Research Center, National Research Institute of Tuberculosis 
      and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Jahangirifard, Alireza
AU  - Jahangirifard A
AUID- ORCID: 0000-0002-5514-3768
AD  - Lung Transplantation Research Center, National Research Institute of Tuberculosis 
      and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Farzanegan, Behrooz
AU  - Farzanegan B
AUID- ORCID: 0000-0002-6353-5761
AD  - Tracheal Diseases Research Center, National Research Institute of Tuberculosis 
      and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Tabarsi, Payam
AU  - Tabarsi P
AUID- ORCID: 0000-0001-6786-1524
AD  - Clinical Tuberculosis and Epidemiology Research Center, National Research 
      Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
FAU - Abtahian, Zahra
AU  - Abtahian Z
AUID- ORCID: 0000-0001-7167-8503
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Abedini, Atefeh
AU  - Abedini A
AUID- ORCID: 0000-0002-4262-9873
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Sharifi, Mehrzad
AU  - Sharifi M
AUID- ORCID: 0000-0002-3105-041X
AD  - Lung Transplantation Research Center, National Research Institute of Tuberculosis 
      and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Jadbabaei, Amir Naser
AU  - Jadbabaei AN
AUID- ORCID: 0000-0001-6955-0092
AD  - Lung Transplantation Research Center, National Research Institute of Tuberculosis 
      and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Mafhumi, Yadollah
AU  - Mafhumi Y
AUID- ORCID: 0000-0002-5882-6425
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Moslem, Ali
AU  - Moslem A
AUID- ORCID: 0000-0003-1414-4753
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Sistani, Marjan
AU  - Sistani M
AUID- ORCID: 0000-0002-8062-6948
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Yousefian, Sahar
AU  - Yousefian S
AUID- ORCID: 0000-0003-0829-6136
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
AD  - Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
FAU - Saffaei, Ali
AU  - Saffaei A
AUID- ORCID: 0000-0002-9563-924X
AD  - Student Research Committee, Department of Clinical Pharmacy, School of Pharmacy, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Dastan, Farzaneh
AU  - Dastan F
AUID- ORCID: 0000-0001-7253-4333
AD  - Chronic Respiratory Diseases Research Center, National Research Institute of 
      Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
AD  - Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Case Reports
DEP - 20200717
PL  - United States
TA  - J Card Surg
JT  - Journal of cardiac surgery
JID - 8908809
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Betacoronavirus
MH  - COVID-19
MH  - Coronavirus Infections/complications/epidemiology/*therapy
MH  - Extracorporeal Membrane Oxygenation/*adverse effects
MH  - Humans
MH  - Middle Aged
MH  - Pandemics
MH  - Pneumonia, Viral/complications/epidemiology/*therapy
MH  - Respiratory Distress Syndrome/etiology/*therapy
MH  - Retrospective Studies
MH  - SARS-CoV-2
MH  - Treatment Failure
PMC - PMC7404852
OTO - NOTNLM
OT  - SARS coronavirus
OT  - SARS-CoV infection
OT  - acute respiratory distress syndrome
OT  - extracorporeal membrane oxygenation
OT  - hypercoagulability
COIS- The authors declare that there are no conflict of interests.
EDAT- 2020/07/18 06:00
MHDA- 2020/10/23 06:00
PMCR- 2020/07/17
CRDT- 2020/07/18 06:00
PHST- 2020/05/23 00:00 [received]
PHST- 2020/06/19 00:00 [revised]
PHST- 2020/07/06 00:00 [accepted]
PHST- 2020/07/18 06:00 [pubmed]
PHST- 2020/10/23 06:00 [medline]
PHST- 2020/07/18 06:00 [entrez]
PHST- 2020/07/17 00:00 [pmc-release]
AID - JOCS14867 [pii]
AID - 10.1111/jocs.14867 [doi]
PST - ppublish
SO  - J Card Surg. 2020 Oct;35(10):2838-2843. doi: 10.1111/jocs.14867. Epub 2020 Jul 
      17.