PMID- 32679137 OWN - NLM STAT- MEDLINE DCOM- 20210514 LR - 20210514 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 320 DP - 2020 Dec 1 TI - The combined effects of cardiac geometry, microcirculation, and tissue characteristics on cardiac systolic and diastolic function in subclinical diabetes mellitus-related cardiomyopathy. PG - 112-118 LID - S0167-5273(20)33461-6 [pii] LID - 10.1016/j.ijcard.2020.07.013 [doi] AB - BACKGROUND: Diabetes mellitus-related cardiomyopathy has recently been described as a distinct progression of left ventricular (LV) systolic and diastolic dysfunction. Pathological changes in the myocardium may explain the development of two different phenotypes. We evaluated the effects of LV geometry, myocardial microcirculation, and tissue characteristics on cardiac deformation in patients with subclinical type 2 diabetes mellitus (T2DM) utilizing multiparametric cardiac magnetic resonance (CMR) imaging. METHODS: A total of 135 T2DM patients and 55 matched controls were prospectively enrolled and performed multiparametric CMR examination. CMR-derived parameters including cardiac geometry, function, microvascular perfusion, T1 mapping, T2 mapping, and strain were analyzed and compared between T2DM patients and controls. RESULTS: The univariable and multivariable analysis of systolic and diastolic function revealed that longer duration of diabetes was associated with decreased longitudinal peak systolic strain rate (PSSR-L) (beta = 0.195, p = .013), and higher remodeling index and higher extracellular volume (ECV) tended to correlate with decreased longitudinal peak diastolic strain rate (PDSR-L) (remodeling index, beta = -0.339, p = .000; ECV, beta = -0.172, p = .026), whereas microvascular perfusion index and T2 value affected both PSSR-L (perfusion index, beta = -0.328, p = .000; T2 value, beta = 0.306, p = .000) and PDSR-L (perfusion index, beta = 0.209, p = .004; T2 value, beta = -0.275, p = .000) simultaneously. CONCLUSIONS: The LV concentric remodeling and myocardial fibrosis correlated with diastolic function, and perfusion function and myocardial edema were associated with both LV systolic and diastolic function. CI - Copyright (c) 2020 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Jiang, Li AU - Jiang L AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China; Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu, Sichuan 610041, China. FAU - Wang, Jin AU - Wang J AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Liu, Xi AU - Liu X AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Li, Zhen-Lin AU - Li ZL AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Xia, Chun-Chao AU - Xia CC AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Xie, Lin-Jun AU - Xie LJ AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu, Sichuan 610041, China. FAU - Gao, Yue AU - Gao Y AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Shen, Meng-Ting AU - Shen MT AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Han, Pei-Lun AU - Han PL AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. FAU - Guo, Ying-Kun AU - Guo YK AD - Department of Radiology, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, 20# South Renmin Road, Chengdu, Sichuan 610041, China. Electronic address: gykpanda@163.com. FAU - Yang, Zhi-Gang AU - Yang ZG AD - Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, Sichuan 610041, China. Electronic address: yangzg666@163.com. LA - eng PT - Journal Article DEP - 20200715 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM MH - *Cardiomyopathies/diagnostic imaging/etiology MH - Case-Control Studies MH - *Diabetes Mellitus, Type 2/complications/diagnostic imaging MH - Humans MH - Magnetic Resonance Imaging, Cine MH - Microcirculation MH - Predictive Value of Tests MH - *Ventricular Dysfunction, Left/diagnostic imaging/etiology MH - Ventricular Function, Left OTO - NOTNLM OT - Cardiac deformation OT - Cardiac magnetic resonance imaging OT - Left ventricular geometry OT - Left ventricular myocardial microcirculation OT - Left ventricular tissue characteristics OT - Subclinical diabetes mellitus-related cardiomyopathy COIS- Declaration of Competing Interest The authors declare that there are no conflicts of interest. EDAT- 2020/07/18 06:00 MHDA- 2021/05/15 06:00 CRDT- 2020/07/18 06:00 PHST- 2019/09/16 00:00 [received] PHST- 2020/05/15 00:00 [revised] PHST- 2020/07/08 00:00 [accepted] PHST- 2020/07/18 06:00 [pubmed] PHST- 2021/05/15 06:00 [medline] PHST- 2020/07/18 06:00 [entrez] AID - S0167-5273(20)33461-6 [pii] AID - 10.1016/j.ijcard.2020.07.013 [doi] PST - ppublish SO - Int J Cardiol. 2020 Dec 1;320:112-118. doi: 10.1016/j.ijcard.2020.07.013. Epub 2020 Jul 15.