PMID- 32679160 OWN - NLM STAT- MEDLINE DCOM- 20210730 LR - 20210730 IS - 1549-4713 (Electronic) IS - 0161-6420 (Linking) VI - 128 IP - 2 DP - 2021 Feb TI - Outcomes of Bilateral Cataract Surgery in Infants 7 to 24 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry. PG - 302-308 LID - S0161-6420(20)30682-5 [pii] LID - 10.1016/j.ophtha.2020.07.020 [doi] AB - PURPOSE: To evaluate outcomes of bilateral cataract surgery in children aged 7 to 24 months and compare rates of adverse events (AEs) with other Toddler Aphakia and Pseudophakia Study (TAPS) registry outcomes. DESIGN: Retrospective clinical study at 10 Infant Aphakia Treatment Study (IATS) sites. Statistical analyses comparing this cohort with previously reported TAPS registry cohorts. PARTICIPANTS: Children enrolled in the TAPS registry between 2004 and 2010. METHODS: Children underwent bilateral cataract surgery with or without intraocular lens (IOL) placement at age 7 to 24 months with 5 years of postsurgical follow-up. MAIN OUTCOME MEASURES: Visual acuity (VA), occurrence of strabismus, AEs, and reoperations. RESULTS: A total of 40 children (76 eyes) who underwent bilateral cataract surgery with primary posterior capsulectomy were identified with a median age at cataract surgery of 11 months (7-23); 68% received a primary IOL. Recurrent visual axis opacification (VAO) occurred in 7.5% and was associated only with the use of an IOL (odds ratio, 6.10; P = 0.005). Glaucoma suspect (GS) was diagnosed in 2.5%, but no child developed glaucoma. In this bilateral cohort, AEs (8/40, 20%), including glaucoma or GS and VAO, and reoperations occurred in a similar proportion to that of the published unilateral TAPS cohort. When analyzed with children aged 1 to 7 months at bilateral surgery, the incidence of AEs and glaucoma or GS correlated strongly with age at surgery (P = 0.011/0.004) and glaucoma correlated with microcornea (P = 0.040) but not with IOL insertion (P = 0.15). CONCLUSIONS: Follow-up to age 5 years after bilateral cataract surgery in children aged 7 to 24 months reveals a low rate of VAO and very rare glaucoma or GS diagnosis compared with infants with cataracts operated at < 7 months of age despite primary IOL implantation in most children in the group aged 7 to 24 months. The use of an IOL increases the risk of VAO irrespective of age at surgery. CI - Copyright (c) 2020 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. FAU - Bothun, Erick D AU - Bothun ED AD - Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota; Department of Ophthalmology and Visual Neurosciences, Minneapolis, University of Minnesota, Minnesota. Electronic address: Bothun.Erick@mayo.edu. FAU - Wilson, M Edward AU - Wilson ME AD - Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, South Carolina. FAU - Yen, Kimberly G AU - Yen KG AD - Departments of Ophthalmology and Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas. FAU - Anderson, Jill S AU - Anderson JS AD - Department of Ophthalmology and Visual Neurosciences, Minneapolis, University of Minnesota, Minnesota. FAU - Weil, Natalie C AU - Weil NC AD - Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia. FAU - Loh, Allison R AU - Loh AR AD - Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon. FAU - Morrison, David AU - Morrison D AD - Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee. FAU - Freedman, Sharon F AU - Freedman SF AD - Departments of Ophthalmology and Pediatrics, Duke University Medical Center, Durham, North Carolina. FAU - Plager, David A AU - Plager DA AD - Department of Ophthalmology, Indiana University, Indianapolis, Indiana. FAU - Vanderveen, Deborah K AU - Vanderveen DK AD - Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. FAU - Traboulsi, Elias I AU - Traboulsi EI AD - Department of Pediatric Ophthalmology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio. FAU - Hodge, David O AU - Hodge DO AD - Department Health Sciences Research, Mayo Clinic, Jacksonville, Florida. FAU - Lambert, Scott R AU - Lambert SR AD - Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon; Departments of Ophthalmology and Pediatrics, Stanford University Medical Center, Palo Alto, California. CN - Toddler Aphakia and Pseudophakia Study LA - eng GR - UL1 TR000135/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20200715 PL - United States TA - Ophthalmology JT - Ophthalmology JID - 7802443 SB - IM MH - Aphakia, Postcataract/*epidemiology MH - Cataract/congenital MH - *Cataract Extraction MH - Child, Preschool MH - Female MH - Follow-Up Studies MH - Glaucoma/diagnosis/etiology MH - Humans MH - Infant MH - *Lens Implantation, Intraocular MH - Lenses, Intraocular/adverse effects MH - Male MH - Pseudophakia/*epidemiology MH - Registries/statistics & numerical data MH - Retrospective Studies MH - Treatment Outcome MH - Vision Disorders/diagnosis/etiology MH - Visual Acuity/physiology OTO - NOTNLM OT - IATS OT - TAPS OT - amblyopia OT - bilateral cataract OT - congenital cataract OT - intraocular lens OT - pediatric cataract EDAT- 2020/07/18 06:00 MHDA- 2021/07/31 06:00 CRDT- 2020/07/18 06:00 PHST- 2020/04/16 00:00 [received] PHST- 2020/06/09 00:00 [revised] PHST- 2020/07/09 00:00 [accepted] PHST- 2020/07/18 06:00 [pubmed] PHST- 2021/07/31 06:00 [medline] PHST- 2020/07/18 06:00 [entrez] AID - S0161-6420(20)30682-5 [pii] AID - 10.1016/j.ophtha.2020.07.020 [doi] PST - ppublish SO - Ophthalmology. 2021 Feb;128(2):302-308. doi: 10.1016/j.ophtha.2020.07.020. Epub 2020 Jul 15.