PMID- 32681118
OWN - NLM
STAT- MEDLINE
DCOM- 20211011
LR  - 20211011
IS  - 1476-5624 (Electronic)
IS  - 1362-4393 (Linking)
VI  - 59
IP  - 1
DP  - 2021 Jan
TI  - Physiological responses to moderate intensity continuous and high-intensity 
      interval exercise in persons with paraplegia.
PG  - 26-33
LID - 10.1038/s41393-020-0520-9 [doi]
AB  - STUDY DESIGN: Randomized crossover. OBJECTIVES: To test differences in the 
      duration and magnitude of physiological response to isocaloric moderate intensity 
      continuous (MICE) and high-intensity interval exercise (HIIE) sessions in persons 
      with spinal cord injury (SCI). SETTING: Academic medical center in Miami, FL, 
      USA. METHODS: Ten adult men (mean +/- s.d.; 39 +/- 10 year old) with chronic 
      (13.2 +/- 8.8 year) paraplegia (T2-T10) completed a graded exercise test. Then, in 
      a randomized order, participants completed MICE and HIIE for a cost of 120 kcal. 
      MICE was performed at 24.6% PO(peak). During HIIE, exercise was completed in 
      2 min work and recovery phases at 70%:10% PO(peak). RESULTS: MICE and HIIE were 
      isocaloric (115.9 +/- 21.8 and 116.6 +/- 35.0 kcal, respectively; p = 0.903), but 
      differed in duration (39.8 +/- 4.6 vs 32.2 +/- 6.2 min; p < 0.001) and average 
      respiratory exchange ratio (RER; 0.90 +/- 0.08 vs 1.01 +/- 0.07; p = 0.002). During 
      MICE, a workrate of 24.6 +/- 6.7% PO(peak) elicited a V̇O(2) of 53.1 +/- 6.5% 
      V̇O(2peak) (10.1 +/- 2.2 ml kg(-1) min(-1)). During HIIE, a workrate at 70% 
      PO(peak) elicited 88.3 +/- 6.7% V̇O(2peak) (16.9 +/- 4.2 ml kg(-1) min(-1)), and 
      29.4 +/- 7.7% of the session was spent at or above 80% V̇O(2peak). During HIIE 
      working phase, RER declined from the first to last interval (1.08 +/- 0.07 vs 
      0.98 +/- 0.09; p < 0.001), reflecting an initially high but declining glycolytic 
      rate. CONCLUSIONS: Compared with MICE, HIIE imposed a greater physiological 
      stimulus while requiring less time to achieve a target caloric expenditure. Thus, 
      exercise intensity might be an important consideration in the tailoring of 
      exercise prescription to address the cardiometabolic comorbidities of SCI.
FAU - McMillan, David W
AU  - McMillan DW
AUID- ORCID: 0000-0003-4167-5656
AD  - The Miami Project to Cure Paralysis, Department of Neurological Surgery, 
      University of Miami Miller School of Medicine, Miami, FL, USA. 
      dmcmillan@med.miami.edu.
AD  - Department of Kinesiology and Sport Science, University of Miami, Coral Gables, 
      FL, USA. dmcmillan@med.miami.edu.
FAU - Maher, Jennifer L
AU  - Maher JL
AD  - Department of Health, University of Bath, Bath, UK.
FAU - Jacobs, Kevin A
AU  - Jacobs KA
AD  - Department of Kinesiology and Sport Science, University of Miami, Coral Gables, 
      FL, USA.
FAU - Nash, Mark S
AU  - Nash MS
AUID- ORCID: 0000-0003-4205-4130
AD  - The Miami Project to Cure Paralysis, Department of Neurological Surgery, 
      University of Miami Miller School of Medicine, Miami, FL, USA.
FAU - Bilzon, James L J
AU  - Bilzon JLJ
AUID- ORCID: 0000-0002-6701-7603
AD  - Department of Health, University of Bath, Bath, UK.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20200717
PL  - England
TA  - Spinal Cord
JT  - Spinal cord
JID - 9609749
SB  - IM
MH  - Adult
MH  - Heart Rate
MH  - *High-Intensity Interval Training
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - *Paraplegia/etiology/therapy
MH  - *Spinal Cord Injuries/complications/therapy
EDAT- 2020/07/19 06:00
MHDA- 2021/10/12 06:00
CRDT- 2020/07/19 06:00
PHST- 2020/02/14 00:00 [received]
PHST- 2020/07/03 00:00 [accepted]
PHST- 2020/06/30 00:00 [revised]
PHST- 2020/07/19 06:00 [pubmed]
PHST- 2021/10/12 06:00 [medline]
PHST- 2020/07/19 06:00 [entrez]
AID - 10.1038/s41393-020-0520-9 [pii]
AID - 10.1038/s41393-020-0520-9 [doi]
PST - ppublish
SO  - Spinal Cord. 2021 Jan;59(1):26-33. doi: 10.1038/s41393-020-0520-9. Epub 2020 Jul 
      17.