PMID- 32681321 OWN - NLM STAT- MEDLINE DCOM- 20210614 LR - 20210614 IS - 1432-2323 (Electronic) IS - 0364-2313 (Linking) VI - 44 IP - 11 DP - 2020 Nov TI - (18)F-fluorocholine PET/CT in MEN1 Patients with Primary Hyperparathyroidism. PG - 3761-3769 LID - 10.1007/s00268-020-05695-9 [doi] AB - BACKGROUND: Primary hyperparathyroidism (HPT1) is the most frequent endocrinopathy in multiple endocrine neoplasia type 1 (MEN1). Its surgical management is challenging. We aimed to describe and compare the imaging findings of parathyroid ultrasound (US), sestaMIBI scintigraphy (sestaMIBI), and (18)F-fluorocholine (FCH) PET/CT in a series of MEN1 patients with HPT1. METHODS: Retrospective analysis of a cohort of MEN1 patients with HPT1 assessed by parathyroid US, sestaMIBI scintigraphy and SPECT/CT, and FCH-PET/CT for potential surgery between 2015 and 2019. RESULTS: Twenty-two patients with a confirmed diagnosis of MEN1 who presented with HPT1 and were assessed by the 3 imaging modalities were included. After imaging workups, 11 patients were operated on for the first time, 4 underwent a redo surgery, and 7 did not undergo an operation. The overall patient-based positivity rate of imaging was 91% (20 of 22) for parathyroid US and 96% (21 of 22) for both sestaMIBI and FCH-PET/CT. The 3 imaging modalities demonstrated negative findings in 1/22 patient who did not undergo surgery. Overall, 3 pathologic glands were not detected by any imaging technique. SestaMIBI and FCH-PET/CT both resulted in the same 3 false-positive results in ectopic areas with a significant uptake on two thymic carcinoid tumors and one inflammatory lymph node. FCH-PET/CT provided more surgically relevant data than sestaMIBI in 4/11 patients with initial surgery and in 1/4 patient who underwent redo surgery. CONCLUSIONS: Compared to sestaMIBI scintigraphy, FCH-PET/CT provides additional information regarding the number of pathologic parathyroid glands and their localization in MEN1 patients with HPT1. FAU - Gauthe, Mathieu AU - Gauthe M AUID- ORCID: 0000-0002-4882-9366 AD - Department of Nuclear Medicine, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Paris, France. AD - AP-HP Health Economics Research Unit, INSERM UMR 1153-CRESS METHODS, Paris, France. FAU - Dierick-Gallet, Anne AU - Dierick-Gallet A AD - Department of Endocrinology, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Universite de Paris, 27, rue du Faubourg Saint Jacques, 75014, Paris, France. FAU - Delbot, Thierry AU - Delbot T AD - Department of Nuclear Medicine, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Paris, France. FAU - Bricaire, Leopoldine AU - Bricaire L AD - Department of Endocrinology, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Universite de Paris, 27, rue du Faubourg Saint Jacques, 75014, Paris, France. FAU - Bertherat, Jerome AU - Bertherat J AD - Department of Endocrinology, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Universite de Paris, 27, rue du Faubourg Saint Jacques, 75014, Paris, France. AD - Universite de Paris, Paris, France. AD - Institut Cochin, Inserm Unite 1016, Centre National de La Recherche Scientifique Unite Mixte de Recherche 8104, Universite de Paris, 75014, Paris, France. FAU - North, Marie-Odile AU - North MO AD - Department of Genetic, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Paris, France. FAU - Cochand-Priollet, Beatrix AU - Cochand-Priollet B AD - Department of Pathology, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Paris, France. FAU - Bouchard, Phillipe AU - Bouchard P AD - Department of Endocrinology, Hopital Saint-Antoine, Assistance Publique-Hopitaux de Paris, Paris, France. FAU - Talbot, Jean-Noel AU - Talbot JN AD - Department of Nuclear Medicine, Hopital Tenon, Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Paris, France. FAU - Groussin, Lionel AU - Groussin L AD - Department of Endocrinology, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Universite de Paris, 27, rue du Faubourg Saint Jacques, 75014, Paris, France. lionel.groussin@aphp.fr. AD - Universite de Paris, Paris, France. lionel.groussin@aphp.fr. AD - Institut Cochin, Inserm Unite 1016, Centre National de La Recherche Scientifique Unite Mixte de Recherche 8104, Universite de Paris, 75014, Paris, France. lionel.groussin@aphp.fr. FAU - Gaujoux, Sebastien AU - Gaujoux S AD - Universite de Paris, Paris, France. AD - Institut Cochin, Inserm Unite 1016, Centre National de La Recherche Scientifique Unite Mixte de Recherche 8104, Universite de Paris, 75014, Paris, France. AD - Department of Pancreatic and Endocrine Surgery, Hopital Cochin, Assistance Publique-Hopitaux de Paris, Paris, France. LA - eng PT - Journal Article DEP - 20200717 PL - United States TA - World J Surg JT - World journal of surgery JID - 7704052 RN - 6029HGL0QP (fluorocholine) RN - 971Z4W1S09 (Technetium Tc 99m Sestamibi) RN - N91BDP6H0X (Choline) SB - IM CIN - World J Surg. 2021 Apr;45(4):1254-1255. PMID: 33247355 CIN - World J Surg. 2021 Apr;45(4):1256. PMID: 33386454 MH - Adolescent MH - Adult MH - Aged MH - Choline/administration & dosage/*analogs & derivatives MH - Female MH - Humans MH - Hyperparathyroidism, Primary/diagnostic imaging/*drug therapy/surgery MH - Male MH - Middle Aged MH - Multiple Endocrine Neoplasia Type 1/complications/*diagnostic imaging/surgery MH - Parathyroid Glands/*diagnostic imaging MH - Positron Emission Tomography Computed Tomography/*methods MH - Radionuclide Imaging/*methods MH - Retrospective Studies MH - Technetium Tc 99m Sestamibi/*administration & dosage MH - Young Adult EDAT- 2020/07/19 06:00 MHDA- 2021/06/16 06:00 CRDT- 2020/07/19 06:00 PHST- 2020/07/05 00:00 [accepted] PHST- 2020/07/19 06:00 [pubmed] PHST- 2021/06/16 06:00 [medline] PHST- 2020/07/19 06:00 [entrez] AID - 10.1007/s00268-020-05695-9 [pii] AID - 10.1007/s00268-020-05695-9 [doi] PST - ppublish SO - World J Surg. 2020 Nov;44(11):3761-3769. doi: 10.1007/s00268-020-05695-9. Epub 2020 Jul 17.