PMID- 32682000
OWN - NLM
STAT- MEDLINE
DCOM- 20211005
LR  - 20211005
IS  - 1872-6232 (Electronic)
IS  - 0378-3782 (Linking)
VI  - 148
DP  - 2020 Sep
TI  - Effects of continued positioning pillow use until a corrected age of six months 
      on cranial deformation and neurodevelopment in preterm infants: A prospective 
      case-control study.
PG  - 105137
LID - S0378-3782(20)30270-X [pii]
LID - 10.1016/j.earlhumdev.2020.105137 [doi]
AB  - BACKGROUND: Preterm infants have a high risk of cranial deformity resulting from 
      external pressures. Such deformity is associated with delayed neurodevelopment. 
      AIMS: We aimed to clarify the effects of continuous use of positioning pillows on 
      cranial deformity and neurodevelopment in preterm infants. METHODS: This 
      prospective case-control study was conducted between November 2018 and August 
      2019. The continuous use of a pillow was initiated after discharge from the 
      neonatal intensive care unit, up to a corrected age of six months. Preterm 
      infants weighing less than 1800 g without neurological abnormalities were 
      included in the study. Patients were divided into two groups: non-pillow group 
      (NP-group) and pillow group (P-group). The primary outcome was the Bayley Scales 
      of Infant Development III (BSID-III) score. We compared asymmetrical cranial 
      deformity and the BSID-III scores in the two groups at a corrected age of six 
      months using the Fisher's exact test and unpaired t-test, respectively. RESULTS: 
      There were 19 preterm infants (mean gestational age 32.5 +/- 1.9 weeks, birth 
      weight 1461.3 +/- 244.7) eligible during the study period. The P-group (n = 11) 
      showed asymmetrical cranial deformity at six months less frequently than the 
      NP-group (n = 8) (p = 0.001, Fisher's exact test). Infants in the P-group had 
      significantly higher scores on the BSID-III cognitive scales (95.0 +/- 8.4 vs. 
      86.9 +/- 2.6; p = 0.02, unpaired t-test) and fine motor scores on the motor scales 
      (8.6 +/- 2.2 vs. 6.6 +/- 0.7, p = 0.02, unpaired t-test). CONCLUSIONS: Continuous 
      pillow use in preterm infants is effective in reducing cranial deformity and 
      improved cognitive and fine motor skills. TRIAL REGISTRATION: UMIN Clinical 
      Trials Registry, trial no. UMIN000034400 (http://www.umin.ac.jp/ctr/index.htm).
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Uchio, Yuu
AU  - Uchio Y
AD  - Department of Rehabilitation, Tokyo Women's Medical University, Tokyo, Japan; 
      Department of Physical Therapy, Graduate School of Human Health Sciences, Tokyo 
      Metropolitan University, Tokyo, Japan; Department of Rehabilitation, Faculty of 
      Health Sciences, University of Tokyo Health Sciences, Tokyo, Japan. Electronic 
      address: yu-uch-247@u-ths.ac.jp.
FAU - Shima, Naoko
AU  - Shima N
AD  - Department of Rehabilitation, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Nakamura, Kaho
AU  - Nakamura K
AD  - Department of Rehabilitation, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Ikai, Tetsuo
AU  - Ikai T
AD  - Department of Rehabilitation Medicine, Tokyo Women's Medical University, Tokyo, 
      Japan.
FAU - Nitta, Osamu
AU  - Nitta O
AD  - Department of Physical Therapy, Graduate School of Human Health Sciences, Tokyo 
      Metropolitan University, Tokyo, Japan.
LA  - eng
SI  - UMIN-CTR/UMIN000034400
PT  - Journal Article
DEP - 20200709
PL  - Ireland
TA  - Early Hum Dev
JT  - Early human development
JID - 7708381
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Child Development
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant Behavior/physiology
MH  - Infant, Newborn
MH  - Infant, Premature/*physiology
MH  - Male
MH  - Motor Activity/physiology
MH  - Plagiocephaly/prevention & control
MH  - Prospective Studies
MH  - Skull/*abnormalities
OTO - NOTNLM
OT  - Deformational plagiocephaly
OT  - Neurodevelopment
OT  - Positioning pillow
OT  - Preterm infants
COIS- Declaration of competing interest The authors have no conflicts of interest to 
      declare.
EDAT- 2020/07/19 06:00
MHDA- 2021/10/06 06:00
CRDT- 2020/07/19 06:00
PHST- 2020/04/21 00:00 [received]
PHST- 2020/07/06 00:00 [revised]
PHST- 2020/07/08 00:00 [accepted]
PHST- 2020/07/19 06:00 [pubmed]
PHST- 2021/10/06 06:00 [medline]
PHST- 2020/07/19 06:00 [entrez]
AID - S0378-3782(20)30270-X [pii]
AID - 10.1016/j.earlhumdev.2020.105137 [doi]
PST - ppublish
SO  - Early Hum Dev. 2020 Sep;148:105137. doi: 10.1016/j.earlhumdev.2020.105137. Epub 
      2020 Jul 9.