PMID- 32682399 OWN - NLM STAT- MEDLINE DCOM- 20210125 LR - 20210125 IS - 1471-2261 (Electronic) IS - 1471-2261 (Linking) VI - 20 IP - 1 DP - 2020 Jul 18 TI - Prognostic of different glomerular filtration rate formulas in patients receiving percutaneous coronary intervention: insights from a multicenter observational cohort. PG - 341 LID - 10.1186/s12872-020-01621-y [doi] LID - 341 AB - BACKGROUND: The relationships of renal dysfunction (RD) and chronic kidney disease (CKD) with prognosis have been well established among non-ST elevation acute coronary syndrome (NSTE-ACS) patients who receive percutaneous coronary intervention (PCI), but the efficacy of different estimated glomerular filtration rate (eGFR) formulas for predicting the prognosis is unknown. METHODS: The cohort originated from a retrospective data, which consecutively enrolled 8197 patients. The eGFR was calculated by the Cockcroft-Gault, Modification of Diet in Renal Disease (MDRD), CKD Epidemiology Collaboration-creatinine, CKD Epidemiology Collaboration-Cys-C, CKD Epidemiology Collaboration-Cys-C-creatinine and a modified abbreviated MDRD (c-aGFR) equations in Chinese CKD patients. Patients were excluded if the eGFR could not be obtained by one of the formulas. Patients were categorized as having normal renal function, mild RD, moderate RD, severe RD, or kidney failure to compare prognosis. The primary outcome was the in-hospital net adverse clinical events (NACE). The secondary outcomes were NACE and all-cause death during follow-up. RESULTS: In total, 2159 NSTE-ACS patients (age: 64.23 +/- 10.25 years; males: 73.7%) were enrolled. 39 (1.8%) patients with in-hospital NACE were observed. During the 3.23 +/- 1.55-year follow-up, 1.7% death and 4.2% NACE were observed in 1 year. The percentage of severe RD patients ranged from 15.4 to 39.2% according to different calculation formulas. A high prevalence of in-hospital NACE was observed in the severe RD groups (ranging from 8 to 14.3% for different formulas). Multiple regression analysis showed that a high eGFR is a protect factor against NACE and all-cause death regardless of the formula use. Receiver operating characteristic curves showed similar predictive performance of the c-aGFR when compared to other formulas (in-hospital NACE: AUC = 0.612, follow-up NACE: AUC = 0.622, and follow-up death: AUC = 0.711). CONCLUSIONS: Severe RD results in a high prevalence of in-hospital NACE in NSTE-ACS patients after PCI regardless of the formulas use. Different formulas have a similar ability to predict in-hospital and long-term prognosis in NSTE-ACS patients. The c-aGFR formula is the simplest and a more convenient formula for use in practice. FAU - Chen, Wei AU - Chen W AD - Clinical College of Fujian Provincial Hospital, Fujian Provincial Hospital, Fujian Provincial Key Laboratory of Cardiovascular Disease, Fujian Provincial Center for Geriatrics, Fujian Medical University, Fujian Cardiovascular Institute, Fuzhou, 350001, China. FAU - Chen, Pengyuan AU - Chen P AD - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai Hospital, The Second Hospital of Nanhai District Foshan City, Foshan, 528000, China. FAU - Ni, Zhonghan AU - Ni Z AD - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China. FAU - Liu, Yuanhui AU - Liu Y AD - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China. FAU - Guo, Wei AU - Guo W AD - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China. FAU - Jiang, Lei AU - Jiang L AD - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China. FAU - Wei, Xuebiao AU - Wei X AD - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China. FAU - Chen, Jiyan AU - Chen J AD - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China. FAU - Tan, Ning AU - Tan N AD - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China. FAU - He, Pengcheng AU - He P AD - Department of Cardiology, Guangdong Provincial People's Hospital's Nanhai Hospital, The Second Hospital of Nanhai District Foshan City, Foshan, 528000, China. gdhpc100@126.com. AD - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510100, China. gdhpc100@126.com. FAU - Guo, Yansong AU - Guo Y AUID- ORCID: 0000-0003-0142-2160 AD - Clinical College of Fujian Provincial Hospital, Fujian Provincial Hospital, Fujian Provincial Key Laboratory of Cardiovascular Disease, Fujian Provincial Center for Geriatrics, Fujian Medical University, Fujian Cardiovascular Institute, Fuzhou, 350001, China. drguoyansong@sina.cn. LA - eng GR - KJ012019084/Outstanding Young Talent Program of Guangdong Provincial People's Hospital/International GR - 81873495/National Natural Science Foundation of China General Program/International GR - 2014-ZQN-ZD-2/Fujian Provincial Health Commission Youth Key Talents Project (Key Category)/International GR - 2018J01242/Natural Science Foundation of Fujian Province/International PT - Journal Article PT - Multicenter Study PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20200718 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 SB - IM MH - Acute Coronary Syndrome/diagnostic imaging/mortality/*therapy MH - Aged MH - China MH - *Decision Support Techniques MH - Female MH - *Glomerular Filtration Rate MH - Humans MH - Kidney/*physiopathology MH - Male MH - Middle Aged MH - *Models, Biological MH - Non-ST Elevated Myocardial Infarction/diagnostic imaging/mortality/*therapy MH - *Percutaneous Coronary Intervention/adverse effects/mortality MH - Predictive Value of Tests MH - Renal Insufficiency, Chronic/*diagnosis/mortality/physiopathology MH - Retrospective Studies MH - Risk Assessment MH - Risk Factors MH - Time Factors MH - Treatment Outcome PMC - PMC7368721 OTO - NOTNLM OT - Non-ST elevation acute coronary syndrome OT - Percutaneous coronary intervention OT - Prognosis OT - Renal dysfunction COIS- The authors declare that there is no conflict of interest. EDAT- 2020/07/20 06:00 MHDA- 2021/01/26 06:00 PMCR- 2020/07/18 CRDT- 2020/07/20 06:00 PHST- 2020/04/12 00:00 [received] PHST- 2020/07/13 00:00 [accepted] PHST- 2020/07/20 06:00 [entrez] PHST- 2020/07/20 06:00 [pubmed] PHST- 2021/01/26 06:00 [medline] PHST- 2020/07/18 00:00 [pmc-release] AID - 10.1186/s12872-020-01621-y [pii] AID - 1621 [pii] AID - 10.1186/s12872-020-01621-y [doi] PST - epublish SO - BMC Cardiovasc Disord. 2020 Jul 18;20(1):341. doi: 10.1186/s12872-020-01621-y.