PMID- 32683211 OWN - NLM STAT- MEDLINE DCOM- 20210111 LR - 20211002 IS - 1873-6750 (Electronic) IS - 0160-4120 (Print) IS - 0160-4120 (Linking) VI - 143 DP - 2020 Oct TI - Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach. PG - 105957 LID - S0160-4120(20)31912-7 [pii] LID - 10.1016/j.envint.2020.105957 [doi] AB - BACKGROUND: Advances in untargeted metabolomic technologies have great potential for insight into adverse metabolic effects underlying exposure to environmental chemicals. However, important challenges need to be addressed, including how biological response corresponds to the environmental chemical burden in different target tissues. AIM: We performed a pilot study using state-of-the-art ultra-high-resolution mass spectrometry (UHRMS) to characterize the burden of lipophilic persistent organic pollutants (POPs) in metabolic tissues and associated alterations in the plasma metabolome. METHODS: We studied 11 adolescents with severe obesity at the time of bariatric surgery. We measured 18 POPs that can act as endocrine and metabolic disruptors (i.e. 2 dioxins, 11 organochlorine compounds [OCs] and 5 polybrominated diphenyl ethers [PBDEs]) in visceral and subcutaneous abdominal adipose tissue (vAT and sAT), and liver samples using gas chromatography with UHRMS. Biological pathways were evaluated by measuring the plasma metabolome using high-resolution metabolomics. Network and pathway enrichment analysis assessed correlations between the tissue-specific burden of three frequently detected POPs (i.e. p,p'-dichlorodiphenyldichloroethene [DDE], hexachlorobenzene [HCB] and PBDE-47) and plasma metabolic pathways. RESULTS: Concentrations of 4 OCs and 3 PBDEs were quantifiable in at least one metabolic tissue for > 80% of participants. All POPs had the highest median concentrations in adipose tissue, especially sAT, except for PBDE-154, which had comparable average concentrations across all tissues. Pathway analysis showed high correlations between tissue-specific POPs and metabolic alterations in pathways of amino acid metabolism, lipid and fatty acid metabolism, and carbohydrate metabolism. CONCLUSIONS: Most of the measured POPs appear to accumulate preferentially in adipose tissue compared to liver. Findings of plasma metabolic pathways potentially associated with tissue-specific POPs concentrations merit further investigation in larger populations. CI - Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Valvi, Damaskini AU - Valvi D AD - Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: dania.valvi@mssm.edu. FAU - Walker, Douglas I AU - Walker DI AD - Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States. Electronic address: douglas.walker@mssm.edu. FAU - Inge, Thomas AU - Inge T AD - Children's Hospital Colorado and University of Colorado, Denver, United States. FAU - Bartell, Scott M AU - Bartell SM AD - Program in Public Health and Department of Statistics, University of California, Irvine, CA, United States. FAU - Jenkins, Todd AU - Jenkins T AD - Cincinnati Children's Hospital and University of Cincinnati Departments of Pediatrics and Surgery, Cincinnati, OH, United States. FAU - Helmrath, Michael AU - Helmrath M AD - Cincinnati Children's Hospital and University of Cincinnati Departments of Pediatrics and Surgery, Cincinnati, OH, United States. FAU - Ziegler, Thomas R AU - Ziegler TR AD - Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States. FAU - La Merrill, Michele A AU - La Merrill MA AD - Department of Environmental Toxicology, University of California, Davis, CA, United States. FAU - Eckel, Sandrah P AU - Eckel SP AD - Department of Preventive Medicine, University of Southern California, Los Angeles, CA, United States. FAU - Conti, David AU - Conti D AD - Department of Preventive Medicine, University of Southern California, Los Angeles, CA, United States. FAU - Liang, Yongliang AU - Liang Y AD - Clinical Biomarkers Laboratory, Department of Medicine, Emory University, Atlanta, GA, United States. FAU - Jones, Dean P AU - Jones DP AD - Clinical Biomarkers Laboratory, Department of Medicine, Emory University, Atlanta, GA, United States. FAU - McConnell, Rob AU - McConnell R AD - Department of Preventive Medicine, University of Southern California, Los Angeles, CA, United States. FAU - Chatzi, Leda AU - Chatzi L AD - Department of Preventive Medicine, University of Southern California, Los Angeles, CA, United States. LA - eng GR - U2C ES030163/ES/NIEHS NIH HHS/United States GR - R21 ES029681/ES/NIEHS NIH HHS/United States GR - P01 ES022845/ES/NIEHS NIH HHS/United States GR - R01 ES030691/ES/NIEHS NIH HHS/United States GR - R21 ES028903/ES/NIEHS NIH HHS/United States GR - R21 ES029328/ES/NIEHS NIH HHS/United States GR - P30 ES023515/ES/NIEHS NIH HHS/United States GR - R01 ES030364/ES/NIEHS NIH HHS/United States GR - R01 ES024946/ES/NIEHS NIH HHS/United States GR - P30 ES019776/ES/NIEHS NIH HHS/United States GR - R01 ES029944/ES/NIEHS NIH HHS/United States GR - U2C ES026561/ES/NIEHS NIH HHS/United States GR - P30 ES007048/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20200717 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Environmental Pollutants) RN - 0 (Halogenated Diphenyl Ethers) RN - 0 (Hydrocarbons, Chlorinated) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Adolescent MH - *Bariatric Surgery MH - *Environmental Pollutants/analysis MH - Gas Chromatography-Mass Spectrometry MH - Halogenated Diphenyl Ethers MH - Humans MH - *Hydrocarbons, Chlorinated/analysis MH - Metabolomics MH - Pilot Projects MH - *Polychlorinated Biphenyls PMC - PMC7708399 MID - NIHMS1613210 OTO - NOTNLM OT - Adipose tissue OT - Bariatric surgery OT - Exposome OT - High-resolution metabolomics OT - Liver OT - Persistent organic pollutants COIS- Conflicts of interest: The authors declare they have no conflict of interest, financial or otherwise. Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/07/20 06:00 MHDA- 2021/01/12 06:00 PMCR- 2021/10/01 CRDT- 2020/07/20 06:00 PHST- 2019/09/14 00:00 [received] PHST- 2020/07/03 00:00 [revised] PHST- 2020/07/04 00:00 [accepted] PHST- 2020/07/20 06:00 [pubmed] PHST- 2021/01/12 06:00 [medline] PHST- 2020/07/20 06:00 [entrez] PHST- 2021/10/01 00:00 [pmc-release] AID - S0160-4120(20)31912-7 [pii] AID - 10.1016/j.envint.2020.105957 [doi] PST - ppublish SO - Environ Int. 2020 Oct;143:105957. doi: 10.1016/j.envint.2020.105957. Epub 2020 Jul 17.