PMID- 32684167
OWN - NLM
STAT- MEDLINE
DCOM- 20201006
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 22
IP  - 1
DP  - 2020 Jul 20
TI  - Motion-corrected 3D whole-heart water-fat high-resolution late gadolinium 
      enhancement cardiovascular magnetic resonance imaging.
PG  - 53
LID - 10.1186/s12968-020-00649-5 [doi]
LID - 53
AB  - BACKGROUND: Conventional 2D inversion recovery (IR) and phase sensitive inversion 
      recovery (PSIR) late gadolinium enhancement (LGE) cardiovascular magnetic 
      resonance (CMR) have been widely incorporated into routine CMR for the assessment 
      of myocardial viability. However, reliable suppression of fat signal, and 
      increased isotropic spatial resolution and volumetric coverage within a 
      clinically feasible scan time remain a challenge. In order to address these 
      challenges, this work proposes a highly efficient respiratory motion-corrected 3D 
      whole-heart water/fat LGE imaging framework. METHODS: An accelerated IR-prepared 
      3D dual-echo acquisition and motion-corrected reconstruction framework for 
      whole-heart water/fat LGE imaging was developed. The acquisition sequence 
      includes 2D image navigators (iNAV), which are used to track the respiratory 
      motion of the heart and enable 100% scan efficiency. Non-rigid motion information 
      estimated from the 2D iNAVs and from the data itself is integrated into a 
      high-dimensional patch-based undersampled reconstruction technique (HD-PROST), to 
      produce high-resolution water/fat 3D LGE images. A cohort of 20 patients with 
      known or suspected cardiovascular disease was scanned with the proposed 3D 
      water/fat LGE approach. 3D water LGE images were compared to conventional 
      breath-held 2D LGE images (2-chamber, 4-chamber and stack of short-axis views) in 
      terms of image quality (1: full diagnostic to 4: non-diagnostic) and presence of 
      LGE findings. RESULTS: Image quality was considered diagnostic in 18/20 datasets 
      for both 2D and 3D LGE magnitude images, with comparable image quality scores 
      (2D: 2.05 +/- 0.72, 3D: 1.88 +/- 0.90, p-value = 0.62) and overall agreement in LGE 
      findings. Acquisition time for isotropic high-resolution (1.3mm(3)) water/fat LGE 
      images was 8.0 +/- 1.4 min (3-fold acceleration, 60-88 slices covering the whole 
      heart), while 2D LGE images were acquired in 5.6 +/- 2.2 min (12-18 slices, 
      including pauses between breath-holds) albeit with a lower spatial resolution 
      (1.40-1.75 mm in-plane x 8 mm slice thickness). CONCLUSION: A novel framework for 
      motion-corrected whole-heart 3D water/fat LGE imaging has been introduced. The 
      method was validated in patients with known or suspected cardiovascular disease, 
      showing good agreement with conventional breath-held 2D LGE imaging, but offering 
      higher spatial resolution, improved volumetric coverage and good image quality 
      from a free-breathing acquisition with 100% scan efficiency and predictable scan 
      time.
FAU - Munoz, Camila
AU  - Munoz C
AUID- ORCID: 0000-0001-5278-4546
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor, Lambeth Wing, London, SE1 7EH, UK. 
      camila.munoz@kcl.ac.uk.
FAU - Bustin, Aurelien
AU  - Bustin A
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor, Lambeth Wing, London, SE1 7EH, UK.
FAU - Neji, Radhouene
AU  - Neji R
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor, Lambeth Wing, London, SE1 7EH, UK.
AD  - MR Research Collaborations, Siemens Healthcare, Frimley, UK.
FAU - Kunze, Karl P
AU  - Kunze KP
AD  - MR Research Collaborations, Siemens Healthcare, Frimley, UK.
FAU - Forman, Christoph
AU  - Forman C
AD  - Cardiovascular MR Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany.
FAU - Schmidt, Michaela
AU  - Schmidt M
AD  - Cardiovascular MR Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany.
FAU - Hajhosseiny, Reza
AU  - Hajhosseiny R
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor, Lambeth Wing, London, SE1 7EH, UK.
FAU - Masci, Pier-Giorgio
AU  - Masci PG
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor, Lambeth Wing, London, SE1 7EH, UK.
FAU - Zeilinger, Martin
AU  - Zeilinger M
AD  - Institute of Radiology, University Hospital Erlangen, Erlangen, Germany.
FAU - Wuest, Wolfgang
AU  - Wuest W
AD  - Institute of Radiology, University Hospital Erlangen, Erlangen, Germany.
FAU - Botnar, Rene M
AU  - Botnar RM
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor, Lambeth Wing, London, SE1 7EH, UK.
FAU - Prieto, Claudia
AU  - Prieto C
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, St 
      Thomas' Hospital, 3rd Floor, Lambeth Wing, London, SE1 7EH, UK.
LA  - eng
GR  - PG/18/59/33955/BHF_/British Heart Foundation/United Kingdom
GR  - DH_/Department of Health/United Kingdom
GR  - WT 203148/Z/16/Z/WT_/Wellcome Trust/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20200720
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Adipose Tissue/*diagnostic imaging/physiopathology
MH  - *Adiposity
MH  - Adult
MH  - Aged
MH  - Body Water/*chemistry
MH  - Breath Holding
MH  - Cardiac-Gated Imaging Techniques
MH  - Cardiovascular Diseases/*diagnostic imaging/physiopathology
MH  - Contrast Media/*administration & dosage
MH  - Electrocardiography
MH  - Female
MH  - Heart/*diagnostic imaging/physiopathology
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Organometallic Compounds/*administration & dosage
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
PMC - PMC7370486
OTO - NOTNLM
OT  - 3D whole-heart
OT  - Accelerated imaging
OT  - Late gadolinium enhancement
OT  - Motion-correction
OT  - Water/fat cardiovascular magnetic resonance imaging
COIS- K.K., R.N., C.F., M.S. are employed by Siemens Healthcare. All other authors 
      declare that they do not have competing interests.
EDAT- 2020/07/21 06:00
MHDA- 2020/10/07 06:00
PMCR- 2020/07/20
CRDT- 2020/07/21 06:00
PHST- 2019/10/03 00:00 [received]
PHST- 2020/06/17 00:00 [accepted]
PHST- 2020/07/21 06:00 [entrez]
PHST- 2020/07/21 06:00 [pubmed]
PHST- 2020/10/07 06:00 [medline]
PHST- 2020/07/20 00:00 [pmc-release]
AID - S1097-6647(23)00305-8 [pii]
AID - 649 [pii]
AID - 10.1186/s12968-020-00649-5 [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2020 Jul 20;22(1):53. doi: 10.1186/s12968-020-00649-5.