PMID- 32684190 OWN - NLM STAT- MEDLINE DCOM- 20200925 LR - 20200925 IS - 2045-7979 (Electronic) IS - 2045-7960 (Print) IS - 2045-7960 (Linking) VI - 29 DP - 2020 Jul 20 TI - Minimum clinically important differences for the Functioning Assessment Short Test and a battery of neuropsychological tests in bipolar disorders: results from the FACE-BD cohort. PG - e144 LID - 10.1017/S2045796020000566 [doi] LID - e144 AB - AIMS: Establishing the minimum clinically important difference (MCID) in functioning and cognition is essential to the interpretation of the research and clinical work conducted in bipolar disorders (BD). The present study aimed to estimate the MCID for the Functioning Assessment Short Test (FAST) and a battery of neuropsychological tests in BD. METHODS: Anchor-based and distributive methods were used to estimate the MCID for the FAST and cognition using data from a large, multicentre, observational cohort of individuals with BD. The FAST and cognition were linked with the Clinical Global Impressions Scale-Severity (CGI-S) and Global Assessment of Functioning (GAF) using an equipercentile method. The magnitude of the standard error measurement (s.e.m.) provided another estimate of the MCID. RESULTS: In total, 570 participants were followed for 2 years. Cross-sectional CGI-S and GAF scores were linked to a threshold ⩽7 on the FAST for functional remission. The MCID for the FAST equalled 8- or 9-points change from baseline using the CGI-S and GAF. One s.e.m. on the FAST corresponded to 7.6-points change from baseline. Cognitive variables insufficiently correlated with anchor variables (all rho <0.3). One s.e.m. for cognitive variables corresponded to a range of 0.45 to 0.93-s.d. change from baseline. CONCLUSIONS: These findings support the value of the estimated MCID for the FAST and cognition and may be a useful tool to evaluate cognitive and functional remediation effects and improve patient functional outcomes in BD. The CGI-S and GAF were inappropriate anchors for cognition. Further studies may use performance-based measures of functioning instead. FAU - Roux, P AU - Roux P AUID- ORCID: 0000-0003-0321-4189 AD - Service Universitaire de Psychiatrie d'Adultes et d'Addictologie, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157Le Chesnay, France. AD - Universite Paris-Saclay, Universite Versailles Saint-Quentin-En-Yvelines, INSERM UMR1018, Centre de recherche en Epidemiologie et Sante des Populations, Equipe DevPsy, 94807Villejuif, France. AD - Fondation Fondamental, Creteil, France. FAU - Brunet-Gouet, E AU - Brunet-Gouet E AD - Service Universitaire de Psychiatrie d'Adultes et d'Addictologie, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157Le Chesnay, France. AD - Universite Paris-Saclay, Universite Versailles Saint-Quentin-En-Yvelines, INSERM UMR1018, Centre de recherche en Epidemiologie et Sante des Populations, Equipe DevPsy, 94807Villejuif, France. AD - Fondation Fondamental, Creteil, France. FAU - Ehrminger, M AU - Ehrminger M AUID- ORCID: 0000-0002-9158-7120 AD - Universite Paris-Saclay, Universite Versailles Saint-Quentin-En-Yvelines, INSERM UMR1018, Centre de recherche en Epidemiologie et Sante des Populations, Equipe DevPsy, 94807Villejuif, France. AD - Fondation Fondamental, Creteil, France. FAU - Aouizerate, B AU - Aouizerate B AD - Fondation Fondamental, Creteil, France. AD - Centre Expert Trouble Bipolaire, Pole de Psychiatrie Generale et Universitaire (3/4/7), Hopital Charles Perrens, Bordeaux, France. FAU - Aubin, V AU - Aubin V AD - Fondation Fondamental, Creteil, France. AD - Pole de Psychiatrie, Centre Hospitalier Princesse Grace, BP489, 98012Monaco, France. FAU - Azorin, J M AU - Azorin JM AD - Fondation Fondamental, Creteil, France. AD - AP-HM, Hopital Sainte-Marguerite, Pole de Psychiatrie, 13274Marseille, France. FAU - Bellivier, F AU - Bellivier F AD - Fondation Fondamental, Creteil, France. AD - AP-HP Paris Nord, DMU Neurosciences, GHU Saint-Louis - Lariboisiere - Fernand Widal, Departement de Psychiatrie et de Medecine Addictologique, Paris, France. AD - Universite de Paris, INSERM UMR-S 1144, Paris, France. FAU - Bougerol, T AU - Bougerol T AD - Fondation Fondamental, Creteil, France. AD - University Grenoble Alpes, CS 40700 38058 Grenoble cedex 9, Grenoble, France. AD - CHU de Grenoble et des Alpes, CS10217, F-38043Grenoble, France. AD - Grenoble Institut des Neurosciences (GIN) Inserm U 836, Chemin Fortune Ferrini, 38706La Tronche, France. FAU - Courtet, P AU - Courtet P AD - Fondation Fondamental, Creteil, France. AD - Department of Emergency Psychiatry & Post-Acute Care, Academic Hospital of Montpellier, Montpellier University, Montpellier, France. AD - INSERM U1061, Montpellier, France. FAU - Dubertret, C AU - Dubertret C AD - Fondation Fondamental, Creteil, France. AD - AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, INSERM U894, Paris Diderot University, Sorbonne Paris Cite, Faculty of Medicine, France. FAU - Kahn, J P AU - Kahn JP AD - Fondation Fondamental, Creteil, France. AD - Fondation Sante des Etudiants de France (FSEF), Clinique Soins-Etudes, 51300Vitry-le-Francois, France. AD - Universite de Lorraine, Nancy, France. FAU - Leboyer, M AU - Leboyer M AD - Fondation Fondamental, Creteil, France. AD - AP-HP, Hopitaux Universitaires Henri Mondor, DHU Pepsy, Pole de Psychiatrie et d'Addictologie, Creteil94000, France. AD - Universite Paris Est, Faculte de Medecine, Creteil94000, France. AD - Inserm, U955, Equipe Psychiatrie Translationnelle, Creteil94000, France. FAU - Olie, E AU - Olie E AD - Fondation Fondamental, Creteil, France. AD - Department of Emergency Psychiatry & Post-Acute Care, Academic Hospital of Montpellier, Montpellier University, Montpellier, France. AD - INSERM U1061, Montpellier, France. CN - FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators FAU - Etain, B AU - Etain B AD - Fondation Fondamental, Creteil, France. AD - AP-HP Paris Nord, DMU Neurosciences, GHU Saint-Louis - Lariboisiere - Fernand Widal, Departement de Psychiatrie et de Medecine Addictologique, Paris, France. AD - Universite de Paris, INSERM UMR-S 1144, Paris, France. AD - Department of Psychological Medicine, Centre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Passerieux, C AU - Passerieux C AD - Service Universitaire de Psychiatrie d'Adultes et d'Addictologie, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157Le Chesnay, France. AD - Universite Paris-Saclay, Universite Versailles Saint-Quentin-En-Yvelines, INSERM UMR1018, Centre de recherche en Epidemiologie et Sante des Populations, Equipe DevPsy, 94807Villejuif, France. AD - Fondation Fondamental, Creteil, France. LA - eng PT - Journal Article DEP - 20200720 PL - England TA - Epidemiol Psychiatr Sci JT - Epidemiology and psychiatric sciences JID - 101561091 SB - IM MH - Bipolar Disorder/*diagnosis/psychology MH - Cognition/*physiology MH - Cognition Disorders/*diagnosis/psychology MH - Cross-Sectional Studies MH - Executive Function MH - Female MH - Humans MH - Male MH - Memory, Short-Term MH - Neuropsychological Tests/*statistics & numerical data MH - Outcome Assessment, Health Care MH - Reaction Time MH - Social Behavior PMC - PMC7372163 OTO - NOTNLM OT - Attention OT - bipolar disorders OT - cognition OT - executive functions OT - memory OT - minimal clinical important differences OT - social functioning OT - speed processing OT - working memory COIS- The authors have no conflicts of interest to state. EDAT- 2020/07/21 06:00 MHDA- 2020/09/26 06:00 PMCR- 2020/07/20 CRDT- 2020/07/21 06:00 PHST- 2020/07/21 06:00 [entrez] PHST- 2020/07/21 06:00 [pubmed] PHST- 2020/09/26 06:00 [medline] PHST- 2020/07/20 00:00 [pmc-release] AID - S2045796020000566 [pii] AID - 10.1017/S2045796020000566 [doi] PST - epublish SO - Epidemiol Psychiatr Sci. 2020 Jul 20;29:e144. doi: 10.1017/S2045796020000566.