PMID- 32684411
OWN - NLM
STAT- MEDLINE
DCOM- 20210609
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 81
IP  - 8
DP  - 2020 Aug
TI  - Genetic polymorphisms of proteasome subunit genes of the MHC-I antigen-presenting 
      system are associated with cervical cancer in a Chinese Han population.
PG  - 445-451
LID - S0198-8859(20)30348-7 [pii]
LID - 10.1016/j.humimm.2020.07.002 [doi]
AB  - Proteasome subunit beta types 8 and 9 (PSMB8, PSMB9) play critical roles in the 
      human leukocyte antigen class I (HLA I)-presenting system. Studies have suggested 
      that polymorphisms in the PSMB8 and PSMB9 genes may influence the immune 
      functions of PSMB8 and PSMB9, and thus be associated with various human cancers. 
      We investigated associations involving single nucleotide polymorphisms (SNPs) 
      rs2071543 in PSMB8, rs1351383, rs17587 and rs2127675 in PSMB9 and risk of 
      cervical intraepithelial neoplasia (CIN) and cervical cancer in a Chinese Han 
      population. A total of 543 patients with CIN, 1008 patients with cervical cancer, 
      and 1120 healthy individuals were enrolled. Agena MassArray was used for SNP 
      genotyping of PSMB8 and PSMB9. Associations involving these SNPs and risk of CIN 
      and cervical cancer were analysed. Our results showed that the PSMB8 T/T and T/G 
      genotypes of rs2071543 may be associated with a higher risk of CIN (P = 0.011, 
      OR = 1.35,95% CI: 1.07-1.70) and cervical cancer (P = 0.006, OR = 1.31, 95% CI: 
      1.08-1.59). For rs17587, the A allele (P = 0.001, OR = 1.303, 95% CI: 
      1.115-1.522), and the A/A and A/G genotypes (P = 0.001, OR = 1.36, 95% CI: 
      1.13-1.63) may be risk factors for cervical cancer. These results indicated that 
      PSMB8 rs2071543 might influence susceptibility to CIN and cervical cancer, and 
      PSMB9 rs17587 might influence cervical cancer susceptibility in a Chinese Han 
      population.
CI  - Copyright (c) 2020 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Li, Chuanyin
AU  - Li C
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China.
FAU - Dai, Shuying
AU  - Dai S
AD  - School of Basic Medical Science, Kunming Medical University, Kunming 650500, 
      China.
FAU - Yan, Zhiling
AU  - Yan Z
AD  - Department of Gynaecologic Oncology, The 3rd Affiliated Hospital of Kunming 
      Medical University, Kunming 650118, China.
FAU - Zhang, Xinwen
AU  - Zhang X
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China.
FAU - Liu, Shuyuan
AU  - Liu S
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China.
FAU - Wang, Xia
AU  - Wang X
AD  - Department of Gynaecologic Oncology, The 3rd Affiliated Hospital of Kunming 
      Medical University, Kunming 650118, China.
FAU - Wang, Jun
AU  - Wang J
AD  - Department of Gynaecologic Oncology, The 3rd Affiliated Hospital of Kunming 
      Medical University, Kunming 650118, China.
FAU - Shi, Li
AU  - Shi L
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China. Electronic address: shili.imb@gmail.com.
FAU - Yao, Yufeng
AU  - Yao Y
AD  - Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union 
      Medical College, Kunming 650118, China. Electronic address: leoyyf@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20200716
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - EC 3.4.25.1 (Proteasome Endopeptidase Complex)
SB  - IM
MH  - Adult
MH  - Antigen-Presenting Cells/*immunology
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Proteasome Endopeptidase Complex/*genetics
MH  - Uterine Cervical Neoplasms/*genetics
MH  - Uterine Cervical Dysplasia/genetics
OTO - NOTNLM
OT  - Association
OT  - CIN
OT  - Cervical cancer
OT  - Chinese Han population
OT  - PSMB8 and PSMB9 genes
OT  - Single nucleotide polymorphisms
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/07/21 06:00
MHDA- 2021/06/10 06:00
CRDT- 2020/07/21 06:00
PHST- 2020/02/09 00:00 [received]
PHST- 2020/06/17 00:00 [revised]
PHST- 2020/07/05 00:00 [accepted]
PHST- 2020/07/21 06:00 [pubmed]
PHST- 2021/06/10 06:00 [medline]
PHST- 2020/07/21 06:00 [entrez]
AID - S0198-8859(20)30348-7 [pii]
AID - 10.1016/j.humimm.2020.07.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2020 Aug;81(8):445-451. doi: 10.1016/j.humimm.2020.07.002. Epub 2020 
      Jul 16.