PMID- 32685557
OWN - NLM
STAT- MEDLINE
DCOM- 20210527
LR  - 20220415
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2020
DP  - 2020
TI  - ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease.
PG  - 5158497
LID - 10.1155/2020/5158497 [doi]
LID - 5158497
AB  - BACKGROUND: This meta-analysis was performed to obtain a more comprehensive 
      estimation of the role of the single nucleotide polymorphism (SNP) rs2241766 in 
      the ADIPOQ gene in the occurrence of diabetic kidney disease (DKD). METHODS: 
      Relevant studies were identified from digital databases such as Embase, PubMed, 
      Medline, Cochrane Library, Google Scholar, WanFang, and Chinese National 
      Knowledge Infrastructure (CNKI). Odds ratios (ORs) with their corresponding 95% 
      confidence intervals (95% CIs) were pooled by means of fixed- or random-effects 
      models. Interstudy heterogeneity was examined using the Q test and I (2) 
      statistic, and sensitivity analysis was implemented to test the statistical 
      stability of the overall estimates. Begg's funnel plot and Egger's test were 
      applied to inspect potential publication bias among the included studies. 
      RESULTS: The overall ORs reflected a positive correlation between the ADIPOQ 
      rs2241766 polymorphism and susceptibility to DKD in the GG vs. TT and GG vs. 
      TT+TG comparisons (OR = 1.51, 95%CI = 1.16 - 1.95; OR = 1.43, 95%CI = 1.11 - 
      1.85). After stratification analyses by ethnicity and disease type, a similar 
      trend was also revealed in the Caucasian and African subgroups as well as in the 
      type 2 diabetes mellitus (T2DM) subgroup. CONCLUSION: The ADIPOQ rs2241766 
      polymorphism may be associated with an increased risk of DKD, especially in 
      Caucasian and African populations as well as in T2DM patients.
CI  - Copyright (c) 2020 Qiuxia Han et al.
FAU - Han, Qiuxia
AU  - Han Q
AD  - School of Medicine, Nankai University, Department of Nephrology, The First 
      Medical Centre, Chinese PLA General Hospital, State Key Laboratory of Kidney 
      Diseases, National Clinical Research Center of Kidney Diseases, China.
FAU - Geng, Wenjia
AU  - Geng W
AD  - Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, 
      Nephrology Institute of Guangdong Provincial Hospital of Chinese Medicine, The 
      Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, China.
FAU - Zhang, Dong
AU  - Zhang D
AUID- ORCID: 0000-0002-6521-9586
AD  - School of Medicine, Nankai University, Department of Nephrology, The First 
      Medical Centre, Chinese PLA General Hospital, State Key Laboratory of Kidney 
      Diseases, National Clinical Research Center of Kidney Diseases, China.
FAU - Cai, Guangyan
AU  - Cai G
AD  - School of Medicine, Nankai University, Department of Nephrology, The First 
      Medical Centre, Chinese PLA General Hospital, State Key Laboratory of Kidney 
      Diseases, National Clinical Research Center of Kidney Diseases, China.
FAU - Zhu, Hanyu
AU  - Zhu H
AUID- ORCID: 0000-0002-8729-4245
AD  - Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, 
      Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, 
      National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of 
      Kidney Disease, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20200628
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/*genetics
MH  - Alleles
MH  - Diabetic Nephropathies/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
PMC - PMC7341419
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/07/21 06:00
MHDA- 2021/05/28 06:00
PMCR- 2020/06/28
CRDT- 2020/07/21 06:00
PHST- 2020/03/17 00:00 [received]
PHST- 2020/05/13 00:00 [accepted]
PHST- 2020/07/21 06:00 [entrez]
PHST- 2020/07/21 06:00 [pubmed]
PHST- 2021/05/28 06:00 [medline]
PHST- 2020/06/28 00:00 [pmc-release]
AID - 10.1155/2020/5158497 [doi]
PST - epublish
SO  - J Diabetes Res. 2020 Jun 28;2020:5158497. doi: 10.1155/2020/5158497. eCollection 
      2020.