PMID- 32685933
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2666-3546 (Electronic)
IS  - 2666-3546 (Linking)
VI  - 5
DP  - 2020 May
TI  - Acute effects of systemic inflammation upon the neuro-glial-vascular unit and 
      cerebrovascular function.
PG  - 100074
LID - 10.1016/j.bbih.2020.100074 [doi]
LID - 100074
AB  - Brain health relies on a tightly regulated system known as neurovascular coupling 
      whereby the cellular constituents of the neuro-glial-vascular unit (NGVU) 
      regulate cerebral haemodynamics in accordance with brain metabolic demand. 
      Disruption of neurovascular coupling impairs brain health and is associated with 
      the development of a number for neurological conditions, including Alzheimer's 
      disease. The NGVU is also a key site of action for neuroinflammatory responses 
      and contributes to the transition of systemic inflammation to neuroinflammatory 
      processes. Thus, systemic inflammatory challenges may cause a shift in NGVU 
      operation towards prioritising neuroinflammatory action and thus altering 
      neurovascular coupling and resultant cerebrovascular changes. To investigate 
      this, rats were injected with lipopolysaccharide (LPS) (2 ​mg/kg) to induce a 
      systemic inflammatory response, or vehicle, and brain haemodynamic responses to 
      sensory and non-sensory (hypercapnia) stimuli were assessed in vivo using optical 
      imaging techniques. Following imaging, animals were perfused and their brains 
      extracted to histologically characterise components of the NGVU to determine the 
      association between underlying cellular changes and in vivo blood flow 
      regulation. LPS-treated animals showed changes in haemodynamic function and 
      cerebrovascular dynamics 6 ​hours after LPS administration. Histological 
      assessment identified a significant increase in astrogliosis, microgliosis and 
      endothelial activation in LPS-treated animals. Our data shows that an acutely 
      induced systemic inflammatory response is able to rapidly alter in vivo 
      haemodynamic function and is associated with significant changes in the cellular 
      constituents of the NGVU. We suggest that these effects are initially mediated by 
      endothelial cells, which are directly exposed to the circulating inflammatory 
      stimulus and have been implicated in regulating functional hyperaemia.
CI  - (c) 2020 The Authors.
FAU - Brezzo, Gaia
AU  - Brezzo G
AD  - The University of Sheffield, Department of Psychology, Cathedral Court, 1 Vicar 
      Lane, Sheffield, S1 2LT, UK.
FAU - Simpson, Julie
AU  - Simpson J
AD  - The University of Sheffield, Sheffield Institute for Translational Neuroscience 
      (SITraN), 385a Glossop Road, Sheffield, S10 2HQ, UK.
FAU - Ameen-Ali, Kamar E
AU  - Ameen-Ali KE
AD  - The University of Sheffield, Department of Psychology, Cathedral Court, 1 Vicar 
      Lane, Sheffield, S1 2LT, UK.
FAU - Berwick, Jason
AU  - Berwick J
AD  - The University of Sheffield, Department of Psychology, Cathedral Court, 1 Vicar 
      Lane, Sheffield, S1 2LT, UK.
FAU - Martin, Chris
AU  - Martin C
AD  - The University of Sheffield, Department of Psychology, Cathedral Court, 1 Vicar 
      Lane, Sheffield, S1 2LT, UK.
LA  - eng
GR  - MR/M013553/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - United States
TA  - Brain Behav Immun Health
JT  - Brain, behavior, & immunity - health
JID - 101759062
PMC - PMC7357601
OTO - NOTNLM
OT  - Inflammation
OT  - Lipopolysaccharide
OT  - Neuro-glial-vascular unit
OT  - Neurovascular coupling
COIS- None.
EDAT- 2020/07/21 06:00
MHDA- 2020/07/21 06:01
PMCR- 2020/04/22
CRDT- 2020/07/21 06:00
PHST- 2020/04/15 00:00 [received]
PHST- 2020/04/17 00:00 [accepted]
PHST- 2020/07/21 06:00 [entrez]
PHST- 2020/07/21 06:00 [pubmed]
PHST- 2020/07/21 06:01 [medline]
PHST- 2020/04/22 00:00 [pmc-release]
AID - S2666-3546(20)30039-9 [pii]
AID - 100074 [pii]
AID - 10.1016/j.bbih.2020.100074 [doi]
PST - ppublish
SO  - Brain Behav Immun Health. 2020 May;5:100074. doi: 10.1016/j.bbih.2020.100074.