PMID- 32686160
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20210623
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 34
IP  - 10
DP  - 2020 Oct
TI  - Changes in 6-minute walking distance in lung transplant candidates while 
      participating in a home-based pre-habilitation program-A retrospective chart 
      review.
PG  - e14045
LID - 10.1111/ctr.14045 [doi]
AB  - Home-based exercise programs may offer a less costly alternative to providing 
      exercise pre-transplant to a large number of patients. We describe the changes in 
      6-minute walk distance (6MWD) in lung transplant candidates who participated in a 
      home-based exercise program and their relationship to post-transplant outcomes. 
      Retrospectively, we investigated 159 individuals while awaiting transplantation 
      who performed the surgery between 2011 and 2015. Primary outcome was 6MWD at time 
      of assessment for transplant, last test prior to transplant and one-month 
      post-transplant. 6MWD decreased by 28 +/- 93.9 m between the time of assessment and 
      the last 6MWD prior to transplantation (P < .001). Forty-one patients (25.8%) 
      increased their 6MWD (mean + 85.8 +/- 42.8 m); 72 patients (45.3%) decreased their 
      6MWD (mean -109.8 +/- 71.2 m); and 46 patients (28.9%) had no change in 6MWD 
      (-1.5 +/- 15.7 m). There was a moderate correlation (r = .528; P < .001) between 
      the last 6MWD prior to transplant and 6MWD post-transplant. Change in 6MWD prior 
      to transplant weakly correlated with length of time on mechanical ventilation 
      (r = -.185; P = .034). When adjusted for covariates, change in 6MWD prior to 
      transplant was not associated with length of time on mechanical ventilation, 
      total hospital LOS, or intensive care unit LOS. The majority of the patients were 
      able to either increase or maintain their 6MWD while participating in a 
      home-based pre-habilitation program during the waiting list period. Prospective 
      research is needed to evaluate the effects of home-based pre-habilitation program 
      for lung candidates.
CI  - (c) 2020 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.
FAU - Massierer, Daniela
AU  - Massierer D
AUID- ORCID: 0000-0002-8854-5413
AD  - School of Physical and Occupational Therapy, McGill University, Montreal, QC, 
      Canada.
AD  - Translational Research in Respiratory Diseases Program, Research Institute of the 
      McGill University Health Centre, Montreal, QC, Canada.
AD  - Centre for Health Outcomes Research and Evaluation (CORE), Research Institute of 
      the McGill University Health Centre, Montreal, QC, Canada.
AD  - Canadian Donation and Transplantation Research Program (CDTRP), Edmonton, AB, 
      Canada.
FAU - Bourgeois, Nicholas
AU  - Bourgeois N
AUID- ORCID: 0000-0002-5078-7775
AD  - Lung transplant program, Centre Hospitalier de l'Universite de Montreal (CHUM), 
      Montreal, QC, Canada.
FAU - Rakel, Agnes
AU  - Rakel A
AD  - Lung transplant program, Centre Hospitalier de l'Universite de Montreal (CHUM), 
      Montreal, QC, Canada.
FAU - Prevost, Karina
AU  - Prevost K
AUID- ORCID: 0000-0003-0899-4890
AD  - Lung transplant program, Centre Hospitalier de l'Universite de Montreal (CHUM), 
      Montreal, QC, Canada.
FAU - Lands, Larry C
AU  - Lands LC
AUID- ORCID: 0000-0003-2478-4412
AD  - Translational Research in Respiratory Diseases Program, Research Institute of the 
      McGill University Health Centre, Montreal, QC, Canada.
AD  - Lung transplant program, Centre Hospitalier de l'Universite de Montreal (CHUM), 
      Montreal, QC, Canada.
FAU - Poirier, Charles
AU  - Poirier C
AUID- ORCID: 0000-0003-0689-6349
AD  - Lung transplant program, Centre Hospitalier de l'Universite de Montreal (CHUM), 
      Montreal, QC, Canada.
FAU - Janaudis-Ferreira, Tania
AU  - Janaudis-Ferreira T
AUID- ORCID: 0000-0003-0944-3791
AD  - School of Physical and Occupational Therapy, McGill University, Montreal, QC, 
      Canada.
AD  - Translational Research in Respiratory Diseases Program, Research Institute of the 
      McGill University Health Centre, Montreal, QC, Canada.
AD  - Centre for Health Outcomes Research and Evaluation (CORE), Research Institute of 
      the McGill University Health Centre, Montreal, QC, Canada.
AD  - Canadian Donation and Transplantation Research Program (CDTRP), Edmonton, AB, 
      Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200817
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Exercise Test
MH  - Exercise Tolerance
MH  - Humans
MH  - *Lung Transplantation
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - *Walking
OTO - NOTNLM
OT  - 6-minute walk test
OT  - exercise
OT  - lung transplantation
OT  - rehabilitation
EDAT- 2020/07/21 06:00
MHDA- 2021/06/24 06:00
CRDT- 2020/07/21 06:00
PHST- 2020/02/17 00:00 [received]
PHST- 2020/06/26 00:00 [revised]
PHST- 2020/07/11 00:00 [accepted]
PHST- 2020/07/21 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2020/07/21 06:00 [entrez]
AID - 10.1111/ctr.14045 [doi]
PST - ppublish
SO  - Clin Transplant. 2020 Oct;34(10):e14045. doi: 10.1111/ctr.14045. Epub 2020 Aug 
      17.