PMID- 32688117
OWN - NLM
STAT- MEDLINE
DCOM- 20201008
LR  - 20201008
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 125
DP  - 2020 Sep
TI  - Development and function of human dendritic cells in humanized mice models.
PG  - 151-161
LID - S0161-5890(20)30411-9 [pii]
LID - 10.1016/j.molimm.2020.07.005 [doi]
AB  - Dendritic cells (DCs) are sentinel cells of the immune system arising from 
      hematopoietic stem cells. DCs play a key role in the regulation of both adaptive 
      and innate lymphocyte responses. As such, experimental models enabling a thorough 
      analysis of human DCs development and function are needed. Humanized mice models 
      (termed collectively as HIS mice, or human immune system mice models) provide 
      unique opportunities to model human hematopoiesis and tackle the function of 
      human immune cell types in vivo. Here, we review experimental approaches enabling 
      to recapitulate the ontogeny of DC subsets in HIS mice and discuss studies 
      addressing the biology of human DC subsets implementing HIS mice models.
CI  - Copyright (c) 2020. Published by Elsevier Ltd.
FAU - Anselmi, Giorgio
AU  - Anselmi G
AD  - King's College London, Centre for Inflammation Biology and Cancer Immunology, The 
      Peter Gorer Department of Immunobiology, United Kingdom.
FAU - Helft, Julie
AU  - Helft J
AD  - PSL Research University, Institut Curie Research Center, Immunity and Cancer 
      department, INSERM U932, Paris, France.
FAU - Guermonprez, Pierre
AU  - Guermonprez P
AD  - King's College London, Centre for Inflammation Biology and Cancer Immunology, The 
      Peter Gorer Department of Immunobiology, United Kingdom; Universite de Paris, 
      Centre for Inflammation Research, CNRS ERL8252, INSERM 1149, Hopital Bichat 
      Claude Bernard, France. Electronic address: pierre.guermonprez@kcl.ac.uk.
LA  - eng
GR  - BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
GR  - C57672/A22369/CRUK_/Cancer Research UK/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200717
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Mice
MH  - *Models, Animal
OTO - NOTNLM
OT  - Dendritic cells
OT  - Engineered stromal cells
OT  - Humanized mice
OT  - NSG
EDAT- 2020/07/21 06:00
MHDA- 2020/10/09 06:00
CRDT- 2020/07/21 06:00
PHST- 2019/11/06 00:00 [received]
PHST- 2020/04/06 00:00 [revised]
PHST- 2020/07/02 00:00 [accepted]
PHST- 2020/07/21 06:00 [pubmed]
PHST- 2020/10/09 06:00 [medline]
PHST- 2020/07/21 06:00 [entrez]
AID - S0161-5890(20)30411-9 [pii]
AID - 10.1016/j.molimm.2020.07.005 [doi]
PST - ppublish
SO  - Mol Immunol. 2020 Sep;125:151-161. doi: 10.1016/j.molimm.2020.07.005. Epub 2020 
      Jul 17.