PMID- 32689638
OWN - NLM
STAT- MEDLINE
DCOM- 20201027
LR  - 20201027
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Linking)
VI  - 29
IP  - 8
DP  - 2020 Aug
TI  - Carotid Calcium Volume and Stenosis after Stent Implantation.
PG  - 104862
LID - S1052-3057(20)30256-1 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2020.104862 [doi]
AB  - INTRODUCTION: Internal carotid artery (ICA) stenosis could be treated with stent 
      placement. It was hypothesized that calcium amount could be predictive of vessel 
      stenosis after stent placement. We utilised computed tomography (CT) angiography 
      to quantify volume of calcium material in bulbar ICA. MATERIALS AND METHODS: 28 
      patients with 31 treated ICA stenosis were collected and analysed using CT 
      angiography-based calcium volume measurement. The Casper stent system (CSS) was 
      used exclusively. Prospective data on emergent carotid stenosis were collected 
      using serial ultrasound controls over a 12-month period. RESULTS: Median age was 
      76 years (interquartile range (IQR) 67.5-77.8) and the majority were men (71.4%). 
      Plaque median calcium volume was 0.142 cm3 (IQR 0.030 - 0.227) and median average 
      Hounsfield Units (HU) were 561.0 (414.5-675.0). We detected positive linear 
      relationship between average HU and ICA calcium volume. Furthermore, weak 
      positive correlation was observed between calcium volume and residual stenosis as 
      seen on post-interventional angiography, (correlation coefficient R = 0.38, 
      p=0.035). Stronger positive correlation emerged between plaques' average HU and 
      residual stenosis (R = 0.42, p=0.018). Angiographic stenosis showed univariate 
      association with late stenosis as detected 12 months after CAS. CONCLUSION: 
      Calcium burden could be associated with residual stenosis after CSS placement. 
      Larger studies are needed to confirm our preliminary data.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Mutzenbach, Johannes Sebastian
AU  - Mutzenbach JS
AD  - Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical 
      University, Salzburg, Austria. Electronic address: j.mutzenbach@salk.at.
FAU - Machegger, Lukas
AU  - Machegger L
AD  - Division of neuroradiology, Christian Doppler Medical Center, Paracelsus Medical 
      University, Salzburg, Austria. Electronic address: l.machegger@salk.at.
FAU - Moscote-Salazar, Luis Rafael
AU  - Moscote-Salazar LR
AD  - Research Institute for Neurointervention, Christian Doppler Medical Center, 
      Paracelsus Medical University, Salzburg, Austria. Electronic address: 
      rafaelmoscote21@gmail.com.
FAU - Killer-Oberpfalzer, Monika
AU  - Killer-Oberpfalzer M
AD  - Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical 
      University, Salzburg, Austria; Research Institute for Neurointervention, 
      Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, 
      Austria. Electronic address: m.killer@salk.at.
FAU - Muller-Thies-Broussalis, Erasmia
AU  - Muller-Thies-Broussalis E
AD  - Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical 
      University, Salzburg, Austria; Research Institute for Neurointervention, 
      Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, 
      Austria. Electronic address: e.broussalis@salk.at.
FAU - Pikija, Slaven
AU  - Pikija S
AD  - Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical 
      University, Salzburg, Austria. Electronic address: s.pikija@salk.at.
LA  - eng
PT  - Journal Article
DEP - 20200608
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
SB  - IM
MH  - Aged
MH  - Carotid Artery, Internal/*diagnostic imaging
MH  - Carotid Stenosis/diagnostic imaging/*therapy
MH  - *Computed Tomography Angiography
MH  - Endovascular Procedures/adverse effects/*instrumentation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Plaque, Atherosclerotic
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - *Stents
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Ultrasonography, Doppler, Color
MH  - Vascular Calcification/diagnostic imaging/*therapy
OTO - NOTNLM
OT  - CT
OT  - Calcium
OT  - Carotid artery
OT  - Stenosis
EDAT- 2020/07/22 06:00
MHDA- 2020/10/28 06:00
CRDT- 2020/07/22 06:00
PHST- 2020/01/18 00:00 [received]
PHST- 2020/03/21 00:00 [revised]
PHST- 2020/04/02 00:00 [accepted]
PHST- 2020/07/22 06:00 [entrez]
PHST- 2020/07/22 06:00 [pubmed]
PHST- 2020/10/28 06:00 [medline]
AID - S1052-3057(20)30256-1 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2020.104862 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104862. doi: 
      10.1016/j.jstrokecerebrovasdis.2020.104862. Epub 2020 Jun 8.