PMID- 32690985
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 12
DP  - 2020
TI  - Coronavirus infection (SARS-CoV-2) in obesity and diabetes comorbidities: is heat 
      shock response determinant for the disease complications?
PG  - 63
LID - 10.1186/s13098-020-00572-w [doi]
LID - 63
AB  - Chronic inflammation is involved in the pathogenesis of several metabolic 
      diseases, such as obesity and type 2 diabetes mellitus (T2DM). With the recent 
      worldwide outbreak of coronavirus disease (SARS-CoV-2), it has been observed that 
      individuals with these metabolic diseases are more likely to develop 
      complications, increasing the severity of the disease and a poorer outcome. 
      Coronavirus infection leads to the activation of adaptive and innate immune 
      responses, resulting in massive inflammation (to so called cytokine storm), which 
      in turn can lead to damage to various tissues, septic shock and multiple organ 
      failure. Recent evidence suggests that the common link between metabolic diseases 
      and SARS-CoV-2 is the inflammatory response (chronic/low-grade for metabolic 
      diseases and acute/intense in coronavirus infection). However, the ability of the 
      infected individuals to resolve the inflammation has not yet been explored. The 
      heat shock response (HSR), an important anti-inflammatory pathway, is reduced in 
      patients with metabolic diseases and, consequently, may impair inflammation 
      resolution and control in patients with SARS-CoV-2, thus enabling its 
      amplification and propagation through all tissues. Herein, we present a new 
      hypothesis that aims to explain the increased severity of SARS-CoV-2 infection in 
      people with metabolic diseases, and the possible benefits of HSR-inducing 
      therapies to improve the inflammatory profile in these patients.
CI  - (c) The Author(s) 2020.
FAU - Krause, Mauricio
AU  - Krause M
AD  - Laboratory of Inflammation, Metabolism and Exercise Research (LAPIMEX) and 
      Laboratory of Cellular Physiology, Department of Physiology, Institute of Basic 
      Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 
      Brazil. GRID: grid.8532.c. ISNI: 0000 0001 2200 7498
FAU - Gerchman, Fernando
AU  - Gerchman F
AD  - Endocrine and Metabolic Unit, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      RS Brazil. GRID: grid.414449.8. ISNI: 0000 0001 0125 3761
AD  - Graduate Program in Medical Sciences: Endocrinology, Department of Internal 
      Medicine, Faculty of Medicine, Porto Alegre, Brazil.
FAU - Friedman, Rogerio
AU  - Friedman R
AD  - Endocrine and Metabolic Unit, Hospital de Clinicas de Porto Alegre, Porto Alegre, 
      RS Brazil. GRID: grid.414449.8. ISNI: 0000 0001 0125 3761
AD  - Graduate Program in Medical Sciences: Endocrinology, Department of Internal 
      Medicine, Faculty of Medicine, Porto Alegre, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20200716
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC7364287
OTO - NOTNLM
OT  - Heat shock response
OT  - Inflammation
OT  - Metabolic diseases
OT  - SARS-CoV-2
COIS- Competing interestsThe authors declare no competing interest as far as the 
      contents of this manuscript are considered.
EDAT- 2020/07/22 06:00
MHDA- 2020/07/22 06:01
PMCR- 2020/07/16
CRDT- 2020/07/22 06:00
PHST- 2020/06/17 00:00 [received]
PHST- 2020/07/13 00:00 [accepted]
PHST- 2020/07/22 06:00 [entrez]
PHST- 2020/07/22 06:00 [pubmed]
PHST- 2020/07/22 06:01 [medline]
PHST- 2020/07/16 00:00 [pmc-release]
AID - 572 [pii]
AID - 10.1186/s13098-020-00572-w [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2020 Jul 16;12:63. doi: 10.1186/s13098-020-00572-w. 
      eCollection 2020.