PMID- 32691470
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 52
IP  - 5
DP  - 2020 Nov
TI  - Prognostic Value of Right Ventricular Dysfunction in Patients With AL 
      Amyloidosis: Comparison of Different Techniques by Cardiac Magnetic Resonance.
PG  - 1441-1448
LID - 10.1002/jmri.27200 [doi]
AB  - BACKGROUND: Right ventricular (RV) dysfunction is common in patients with amyloid 
      light-chain (AL) amyloidosis. While cardiac MRI is the reference standard tool 
      for RV assessment, there are a number of measures of RV function that can be 
      evaluated and it is yet unknown which of these results in the highest prognostic 
      performance in AL amyloidosis. PURPOSE: To examine the prognostic value of 
      various measures of RV function in a bid to find which best predicts outcome in 
      AL amyloidosis. STUDY TYPE: Single-center, prospective. SUBJECTS: In all, 129 
      patients (mean age, 58 +/- 11 years; 61.2% men) with biopsy-proven AL amyloidosis. 
      FIELD STRENGTH/SEQUENCE: 3.0T / balanced steady-state free-precession cine. 
      ASSESSMENT: RV ejection fraction (EF), RV fractional area change (FAC), RV long 
      axis strain (LAS), RV free wall longitudinal strain (FWS), RV global longitudinal 
      strain (GLS), and tricuspid annular plane systolic excursion (TAPSE). STATISTICAL 
      TESTS: Mann-Whitney U-tests, Student's t-tests, receiver-operating characteristic 
      curves, Kaplan-Meier curves, Cox proportional hazards regression models, and 
      C-statistics. RESULTS: During the median follow-up period of 38.0 months 
      (interquartile range, 18.5-58.0 months), all-cause mortality occurred in 95 
      patients (73.6%). The RVEF, RVGLS, TAPSE, RVFAC, and RVFWS were significant 
      predictors of outcome in univariate Cox regression (all P < 0.001). After 
      adjusting for New York Heart Association (NYHA) class, Mayo staging 2004, left 
      ventricular (LV) EF, and LV mass index, RVFWS (HR [hazard ratio] =1.074; 95% CI 
      [confidence interval]: 1.041-1.108; P < 0.001) was an independent predictor of 
      all-cause mortality and had a higher C-statistic (0.753) compared to the model 
      including RVEF (C-statistic = 0.724, P = 0.034), the model including RVFAC 
      (C-statistic = 0.723, P = 0.033), and the model including RVGLS (C-statistic 
      =0.733, P = 0.011). DATA CONCLUSION: RV dysfunction appears to be an independent 
      determinant of outcome in patients with AL amyloidosis. RVFWS is a better 
      predictor of all-cause mortality than RVEF, RVFAC, or RVGLS. EVIDENCE LEVEL: 2 
      TECHNICAL EFFICACY STAGE: 5.
CI  - (c) 2020 International Society for Magnetic Resonance in Medicine.
FAU - Wan, Ke
AU  - Wan K
AD  - Department of Geriatrics and National Clinical Research Center for Geriatrics, 
      West China Hospital, Sichuan University, Chengdu, China.
FAU - Lin, Jiayi
AU  - Lin J
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Guo, Xinli
AU  - Guo X
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Song, Rizhen
AU  - Song R
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Xu, Yuanwei
AU  - Xu Y
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Li, Weihao
AU  - Li W
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Cheng, Wei
AU  - Cheng W
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Sun, Jiayu
AU  - Sun J
AD  - Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
FAU - Zhang, Qing
AU  - Zhang Q
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Han, Yuchi
AU  - Han Y
AD  - Department of Medicine (Cardiovascular Division), University of Pennsylvania, 
      Philadelphia, Pennsylvania, USA.
FAU - Chen, Yucheng
AU  - Chen Y
AUID- ORCID: 0000-0002-0601-8039
AD  - Department of Cardiology, West China Hospital, Sichuan University, Chengdu, 
      China.
AD  - Center of Rare diseases, West China Hospital, Sichuan University, Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200720
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - *Immunoglobulin Light-chain Amyloidosis/diagnostic imaging
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Stroke Volume
MH  - *Ventricular Dysfunction, Right/diagnostic imaging
MH  - Ventricular Function, Right
OTO - NOTNLM
OT  - AL amyloidosis
OT  - magnetic resonance imaging
OT  - prognosis
OT  - right ventricle
EDAT- 2020/07/22 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/07/22 06:00
PHST- 2020/02/10 00:00 [received]
PHST- 2020/04/30 00:00 [revised]
PHST- 2020/05/01 00:00 [accepted]
PHST- 2020/07/22 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/07/22 06:00 [entrez]
AID - 10.1002/jmri.27200 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2020 Nov;52(5):1441-1448. doi: 10.1002/jmri.27200. Epub 
      2020 Jul 20.