PMID- 32692694
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20210927
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 59
IP  - 1
DP  - 2020 Jul 21
TI  - The emerging role of cell senescence in atherosclerosis.
PG  - 27-38
LID - cclm-2020-0601 [pii]
LID - 10.1515/cclm-2020-0601 [doi]
AB  - Cell senescence is a fundamental mechanism of aging and appears to play vital 
      roles in the onset and prognosis of cardiovascular disease, fibrotic pulmonary 
      disease, liver disease and tumor. Moreover, an increasing body of evidence shows 
      that cell senescence plays an indispensable role in the formation and development 
      of atherosclerosis. Multiple senescent cell types are associated with 
      atherosclerosis, senescent human vascular endothelial cells participated in 
      atherosclerosis via regulating the level of endothelin-1 (ET-1), nitric oxide 
      (NO), angiotensin II and monocyte chemoattractant protein-1 (MCP-1), senescent 
      human vascular smooth muscle cells-mediated plaque instability and vascular 
      calcification via regulating the expression level of BMP-2, OPN, Runx-2 and 
      inflammatory molecules, and senescent macrophages impaired cholesterol efflux and 
      promoted the development of senescent-related cardiovascular diseases. This 
      review summarizes the characteristics of cell senescence and updates the 
      molecular mechanisms underlying cell senescence. Moreover, we also discuss the 
      recent advances on the molecular mechanisms that can potentially regulate the 
      development and progression of atherosclerosis.
FAU - Wu, Chang-Meng
AU  - Wu CM
AD  - Department of Laboratory Medicine Center, Nanfang Hospital, Southern Medical 
      University, Guangzhou, Guangdong, P. R. China.
FAU - Zheng, Lei
AU  - Zheng L
AD  - Department of Laboratory Medicine Center, Nanfang Hospital, Southern Medical 
      University, Guangzhou, Guangdong, P. R. China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Department of Laboratory Medicine Center, Nanfang Hospital, Southern Medical 
      University, Guangzhou, Guangdong, P. R. China.
FAU - Hu, Yan-Wei
AU  - Hu YW
AD  - Department of Laboratory Medicine Center, Nanfang Hospital, Southern Medical 
      University, Guangzhou, Guangdong, P. R. China.
AD  - Department of Clinical Laboratory, Guangzhou Women & Children Medical Center, 
      Guangzhou Medical University, Guangzhou, P. R. China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20200721
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
SB  - IM
MH  - Atherosclerosis/*etiology/metabolism
MH  - Cellular Senescence/*physiology
MH  - Endothelial Cells/metabolism
MH  - Endothelium, Vascular/cytology/metabolism
MH  - Humans
MH  - Macrophages/metabolism
MH  - Muscle, Smooth, Vascular/cytology/metabolism
MH  - Myocytes, Smooth Muscle/metabolism
OTO - NOTNLM
OT  - HVECs
OT  - HVSMCs
OT  - atherosclerosis
OT  - cell senescence
OT  - macrophages
EDAT- 2020/07/22 06:00
MHDA- 2021/09/28 06:00
CRDT- 2020/07/22 06:00
PHST- 2020/04/27 00:00 [received]
PHST- 2020/06/15 00:00 [accepted]
PHST- 2020/07/22 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2020/07/22 06:00 [entrez]
AID - cclm-2020-0601 [pii]
AID - 10.1515/cclm-2020-0601 [doi]
PST - epublish
SO  - Clin Chem Lab Med. 2020 Jul 21;59(1):27-38. doi: 10.1515/cclm-2020-0601.