PMID- 32693732
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1568-5624 (Electronic)
IS  - 0920-5063 (Linking)
VI  - 31
IP  - 17
DP  - 2020 Dec
TI  - IL-4 functionalized titanium dioxide nanotubes modulate the inflammatory response 
      of macrophages.
PG  - 2238-2251
LID - 10.1080/09205063.2020.1799534 [doi]
AB  - Inflammatory response is an essential part of optimal tissue-implant integration 
      and the regeneration process. Due to their highly plastic properties, macrophages 
      display phenotypic changes during inflammatory signaling. Investigating these 
      changes on implant surfaces is essential for evaluating implant stability and 
      longevity. In order to control macrophage polarization, IL-4 was conjugated to 
      titanium dioxide nanotubes (TNTs) through polydopamine, and successful 
      fabrication was checked by scanning electron microscopy (SEM), atomic force 
      microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and contact angle, 
      respectively. In vitro experiments including immunofluorescence staining, cell 
      proliferation, the expression of genes associated with pro-inflammatory M1 
      phenotype (tumor necrosis factor-alpha (TNF-alpha), Interleukin-18 (IL-18)) and 
      cytokines related to the anti-inflammatory M2 phenotype (IL-4 and IL-10), and the 
      production of nitric oxide (NO) and cytokines TNF-alpha, IL-10 were detected. 
      Macrophage response showed that IL-4 functionalized TNTs favored macrophage 
      polarization towards an anti-inflammatory M2-phenotype. This study provides a new 
      strategy for use in medical devices and the development of advanced 
      nano-biomaterials in immunotherapy applications.
FAU - Yan, Xufeng
AU  - Yan X
AD  - Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing 
      Medical and Pharmaceutical College, Chongqing, China.
AD  - School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
FAU - Shen, Ke
AU  - Shen K
AD  - School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
FAU - Tang, Qiang
AU  - Tang Q
AD  - School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
FAU - Fang, Xingtang
AU  - Fang X
AD  - School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
FAU - Zhang, Chunlei
AU  - Zhang C
AD  - School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
FAU - Zhu, Zhaojing
AU  - Zhu Z
AD  - Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing 
      Medical and Pharmaceutical College, Chongqing, China.
FAU - Hou, Yanhua
AU  - Hou Y
AD  - Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing 
      Medical and Pharmaceutical College, Chongqing, China.
FAU - Lai, Min
AU  - Lai M
AD  - School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200810
PL  - England
TA  - J Biomater Sci Polym Ed
JT  - Journal of biomaterials science. Polymer edition
JID - 9007393
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 207137-56-2 (Interleukin-4)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - *Interleukin-4
MH  - Macrophages
MH  - *Nanotubes
MH  - Surface Properties
MH  - Titanium
OTO - NOTNLM
OT  - IL-4
OT  - inflammatory
OT  - macrophage
OT  - polarization
OT  - titanium dioxide nanotubes
EDAT- 2020/07/23 06:00
MHDA- 2021/10/16 06:00
CRDT- 2020/07/23 06:00
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2020/07/23 06:00 [entrez]
AID - 10.1080/09205063.2020.1799534 [doi]
PST - ppublish
SO  - J Biomater Sci Polym Ed. 2020 Dec;31(17):2238-2251. doi: 
      10.1080/09205063.2020.1799534. Epub 2020 Aug 10.