PMID- 32693893
OWN - NLM
STAT- MEDLINE
DCOM- 20200826
LR  - 20200826
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 49
IP  - 3
DP  - 2020 May
TI  - [Effects of different varieties and processing degree grains on blood glucose and 
      blood lipid in rats].
PG  - 434-441
AB  - OBJECTIVE: To investigate the effects of whole grains(WG) and refined grains(RG) 
      on blood glucose, blood lipid and inflammatory factors in normal rats, and the 
      common effects of different whole grains. METHODS: 2x2 factorial experiments were 
      designed according to grain sources(rice & wheat) and processing 
      precision(whole grain & refined grain). According to the initial body weight 
      and fasting blood glucose, 48 male SD rats were randomly divided into four 
      groups: RG rice group, WG rice group, RG wheat group and WG wheat group. They 
      were fed with 45% refined rice, whole grain rice, refined wheat and whole grain 
      wheat respectively for 18 weeks. The formula was in accordance with AIN-93 G. 
      Food intake and body weight were monitored weekly. Fasting blood glucose, lipid, 
      inflammatory factors and organ pathology were detected at the end of the 
      experiment. RESULTS: During the experiment, the body weight growth and food 
      intake of rats in each group were basically the same. At the end of the 
      experiment, fatty liver appeared in varying degrees, while the kidney of rats in 
      RG rice group and RG wheat group showed epithelial steatosis. Biochemical indexes 
      showed that blood urea nitrogen(UN), fasting blood glucose(FBG), total 
      cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL)and monocyte 
      chemoattractant protein-1(MCP-1)in RG wheat group were significantly higher than 
      those in WG wheat group(P<0. 05), while high density lipoprotein(HDL)level in 
      RG wheat group was significantly lower than that in WG wheat group(P<0. 05), 
      and there was no significant difference in other indexes. The result of factorial 
      analysis showed that the differences of FBG, serum insulin, homeostasis model 
      assessment of insulin resistance(HOMA-IR)and C-reactive protein(CRP)caused by 
      different grain processing degree were significant, but there was no significant 
      difference between rice and wheat varieties(P>0. 05). CONCLUSION: Studies have 
      shown that long-term feeding of refined grains can lead to fasting blood glucose, 
      blood lipid abnormality and renal pathological changes in rats, and proper 
      feeding of whole grains can delay the development of adverse symptoms.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - National Institute for Nutrition and Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100050, China.
FAU - Xiang, Xuesong
AU  - Xiang X
AD  - National Institute for Nutrition and Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100050, China.
FAU - Gao, Chao
AU  - Gao C
AD  - National Institute for Nutrition and Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100050, China.
FAU - Zhang, Xuesong
AU  - Zhang X
AD  - National Institute for Nutrition and Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100050, China.
FAU - Gao, Pin
AU  - Gao P
AD  - National Institute for Nutrition and Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100050, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - National Institute for Nutrition and Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100050, China.
FAU - Wang, Zhu
AU  - Wang Z
AD  - National Institute for Nutrition and Health, Chinese Center for Disease Control 
      and Prevention, Beijing 100050, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
SB  - IM
MH  - Animals
MH  - *Blood Glucose
MH  - Edible Grain
MH  - Lipids
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Whole Grains
OTO - NOTNLM
OT  - abnormal sugar and lipid
OT  - chronic inflammation
OT  - food intake
OT  - liver and kidney function
OT  - refined grain
OT  - whole grain
EDAT- 2020/07/23 06:00
MHDA- 2020/08/28 06:00
CRDT- 2020/07/23 06:00
PHST- 2020/07/23 06:00 [entrez]
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2020/08/28 06:00 [medline]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2020 May;49(3):434-441.