PMID- 32694573
OWN - NLM
STAT- MEDLINE
DCOM- 20201204
LR  - 20210721
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jul 21
TI  - Impaired learning from regret and disappointment in alcohol use disorder.
PG  - 12104
LID - 10.1038/s41598-020-68942-y [doi]
LID - 12104
AB  - The development of alcohol habits is considered a form of maladaptive reinforced 
      learning, with sustained alcohol use resulting in the strengthening of 
      associative links between consumption and either rewarding, or the lack of 
      aversive, experiences. Despite recent efforts in characterizing decision-making 
      skills in alcohol-use-disorder (AUD), it is still unknown whether impaired 
      behavioural learning in AUD patients reflects a defective processing and 
      anticipation of choice-related, cognitively mediated, emotions such as regret or 
      relief for what might have been under a different choice. We administered a 
      Wheel-of-Fortune (WoF) task to 26 AUD patients and 19 healthy controls, to 
      investigate possible alterations in adjusting choices to the magnitude of 
      experienced regret/relief, and in other facets of decision-making performance 
      such as choice latency. AUD patients displayed both longer deliberation time than 
      healthy controls, and impaired adaptations to previous outcome-related negative 
      emotions. Although further evidence is needed to unveil the cognitive mechanisms 
      underlying AUD patients' abnormal choice, the present results highlight important 
      implications for the clinical practice, e.g. in terms of cognitive treatments 
      aiming to shape faulty perceptions about negative emotions associated with 
      excessive alcohol exposure.
FAU - Galandra, Caterina
AU  - Galandra C
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Cognitive Neuroscience Laboratory, 
      27100, Pavia, Italy.
FAU - Crespi, Chiara
AU  - Crespi C
AD  - Department of Brain and Behavioral Sciences, University of Pavia, Piazza Botta 6, 
      27100, Pavia, Italy. chiara.crespi@unipv.it.
FAU - Basso, Gianpaolo
AU  - Basso G
AD  - University of Milano-Bicocca, 20126, Milan, Italy.
FAU - Canessa, Nicola
AU  - Canessa N
AD  - Istituti Clinici Scientifici Maugeri IRCCS, Cognitive Neuroscience Laboratory, 
      27100, Pavia, Italy.
AD  - NEtS Center, Scuola Universitaria Superiore IUSS Pavia, 27100, Pavia, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200721
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adaptation, Psychological
MH  - Adult
MH  - Alcoholism/*psychology
MH  - Case-Control Studies
MH  - Decision Making
MH  - *Emotions
MH  - Female
MH  - Humans
MH  - *Learning
MH  - Male
MH  - Middle Aged
PMC - PMC7374698
COIS- The authors declare no competing interests.
EDAT- 2020/07/23 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/07/21
CRDT- 2020/07/23 06:00
PHST- 2020/03/02 00:00 [received]
PHST- 2020/06/25 00:00 [accepted]
PHST- 2020/07/23 06:00 [entrez]
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/07/21 00:00 [pmc-release]
AID - 10.1038/s41598-020-68942-y [pii]
AID - 68942 [pii]
AID - 10.1038/s41598-020-68942-y [doi]
PST - epublish
SO  - Sci Rep. 2020 Jul 21;10(1):12104. doi: 10.1038/s41598-020-68942-y.