PMID- 32695620
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 2223-3652 (Print)
IS  - 2223-3660 (Electronic)
IS  - 2223-3652 (Linking)
VI  - 10
IP  - 3
DP  - 2020 Jun
TI  - Obstructive sleep apnea versus central sleep apnea: prognosis in systolic heart 
      failure.
PG  - 396-404
LID - 10.21037/cdt.2020.03.02 [doi]
AB  - BACKGROUND: In chronic heart failure (CHF), obstructive sleep apnea (OSA) and 
      Cheyne-Stokes respiration (CSR) are associated with increased mortality. The 
      present study aimed to evaluate the prognostic effect of CSR compared to OSA, in 
      otherwise similar groups of CHF patients. METHODS: Screening for sleep-disordered 
      breathing (SDB) was conducted among patients with CHF of New York Heart 
      Association (NYHA) class II-IV, and left ventricular ejection fraction (LVEF) of 
      </=45%. The study included 43 patients (4 women) with >25% CSR during sleeping 
      time, and 19 patients (2 women) with OSA and an apnea-hypopnea index (AHI) of >/=6. 
      Patients were followed for a median of 1,371 days. The primary endpoint was 
      mortality, and the secondary endpoint was combined mortality and hospital 
      admissions. RESULTS: Baseline parameters did not significantly differ between 
      groups, but CSR patients were older and had higher AHI values than OSA patients. 
      Five OSA patients (26%) died, and 14 (74%) met the combined end-point of death or 
      hospitalization. CSR patients had significantly higher risk for both end-points, 
      with 23 (53%) deaths [log-rank P=0.040; HR, 2.70 (1.01-7.22); P=0.047] and 40 
      (93%) deaths or readmissions [log-rank P=0.029; HR, 1.96 (1.06-3.63); P=0.032]. 
      After adjustment for confounding risk factors, the association between CSR and 
      death remained significant [HR, 4.73 (1.10-20.28); P=0.037], hospital admission 
      rates were not significantly different. CONCLUSIONS: Among patients with CHF, CSR 
      was associated with higher mortality than OSA independently of age and cardiac 
      systolic function. CSR was also an age-independent predictor of unfavorable 
      outcome, but hospital admission rates were not significantly different between 
      the two groups after adjustment.
CI  - 2020 Cardiovascular Diagnosis and Therapy. All rights reserved.
FAU - Hetland, Arild
AU  - Hetland A
AD  - Department of Cardiology, The Hospital of Oestfold, Oestfold, Norway.
AD  - Faculty of Medicine, University of Oslo, Oslo, Norway.
FAU - Vistnes, Maria
AU  - Vistnes M
AD  - Department of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway.
FAU - Haugaa, Kristina H
AU  - Haugaa KH
AD  - Faculty of Medicine, University of Oslo, Oslo, Norway.
AD  - Department of Cardiology and Center for Cardiological Innovation, Oslo University 
      Hospital, Rikshospitalet Oslo, Oslo, Norway.
FAU - Liland, Kristian Hovde
AU  - Liland KH
AD  - Faculty of Science and Technology, Norwegian University of Life Sciences, As, 
      Norway.
FAU - Olseng, Margareth
AU  - Olseng M
AD  - Department of Cardiology, The Hospital of Oestfold, Oestfold, Norway.
FAU - Edvardsen, Thor
AU  - Edvardsen T
AD  - Faculty of Medicine, University of Oslo, Oslo, Norway.
AD  - Department of Cardiology and Center for Cardiological Innovation, Oslo University 
      Hospital, Rikshospitalet Oslo, Oslo, Norway.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Cardiovasc Diagn Ther
JT  - Cardiovascular diagnosis and therapy
JID - 101601613
PMC - PMC7369271
OTO - NOTNLM
OT  - Cheyne-Stokes respiration (CSR)
OT  - chronic heart failure (CHF)
OT  - obstructive sleep apnea (OSA)
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/cdt.2020.03.02). MV reports other 
      from License agreement with Paradigm Biopharma, outside the submitted work. In 
      addition, MV has a patent Uses of enzyme inhibitors pending. The authors have no 
      other conflicts of interest to declare.
EDAT- 2020/07/23 06:00
MHDA- 2020/07/23 06:01
PMCR- 2020/06/01
CRDT- 2020/07/23 06:00
PHST- 2020/07/23 06:00 [entrez]
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2020/07/23 06:01 [medline]
PHST- 2020/06/01 00:00 [pmc-release]
AID - cdt-10-03-396 [pii]
AID - 10.21037/cdt.2020.03.02 [doi]
PST - ppublish
SO  - Cardiovasc Diagn Ther. 2020 Jun;10(3):396-404. doi: 10.21037/cdt.2020.03.02.