PMID- 32695830
OWN - NLM
STAT- MEDLINE
DCOM- 20210609
LR  - 20220415
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2020
DP  - 2020
TI  - Associations of KCNQ1 Polymorphisms with the Risk of Type 2 Diabetes Mellitus: An 
      Updated Meta-Analysis with Trial Sequential Analysis.
PG  - 7145139
LID - 10.1155/2020/7145139 [doi]
LID - 7145139
AB  - BACKGROUND: Previous studies have examined the role of the KQT-like subfamily Q 
      member1 (KCNQ1) gene polymorphisms on the risk of type 2 diabetes mellitus 
      (T2DM), but the findings are inconclusive. OBJECTIVE: To examine the association 
      between the KCNQ1 gene polymorphisms and the risk of T2DM using an updated 
      meta-analysis with an almost tripled number of studies. METHODS: Five electronic 
      databases, such as PubMed and Embase, were searched thoroughly for relevant 
      studies on the associations between seven most studied KCNQ1 gene polymorphisms, 
      including rs2237892, rs2237897, rs2237895, rs2283228, rs231362, rs151290, and 
      rs2074196, and T2DM risk up to September 14, 2019. The summary odds ratios (ORs) 
      with their 95% confidence intervals (CIs) were applied to assess the strength of 
      associations in the random-effects models. We used the trial sequential analysis 
      (TSA) to measure the robustness of the evidence. RESULTS: 49 publications 
      including 55 case-control studies (68,378 cases and 66,673 controls) were finally 
      enrolled. In overall analyses, generally, increased T2DM risk was detected for 
      rs2237892, rs2237895, rs2283228, rs151290, and rs2074196, but not for rs231362 
      under all genetic models. The ORs and 95% CIs for allelic comparison were 1.23 
      (1.14-1.33) for rs2237892, 1.21 (1.16-1.27) for rs2237895, 1.27 (1.11-1.46) for 
      rs2237897, 1.25 (1.09-1.42) for rs2283228, 1.14 (1.03-1.27) for rs151290, 1.31 
      (1.23-1.39) for rs2074196, and 1.16 (0.83, 1.61) for rs231362. Stratified 
      analyses showed that associations for rs2237892, rs2237895, rs2283228, and 
      rs151290 were more evident among Asians than Caucasians. TSA demonstrated that 
      the evidence was sufficient for all polymorphisms in this study. The genotypes of 
      the three SNPs (rs2237892, rs2283228, and rs231362) were significantly correlated 
      with altered KCNQ1 gene expression. CONCLUSION: This meta-analysis suggested that 
      KCNQ1 gene polymorphisms (rs2237892, rs2283228, rs2237895, rs151290, and 
      rs2074196) might be the susceptible factors for T2DM, especially among Asian 
      population.
CI  - Copyright (c) 2020 Xiao-xuan Yu et al.
FAU - Yu, Xiao-Xuan
AU  - Yu XX
AUID- ORCID: 0000-0002-6730-0935
AD  - Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu 
      Road West, Guangzhou, 510632 Guangdong, China.
FAU - Liao, Min-Qi
AU  - Liao MQ
AUID- ORCID: 0000-0003-4382-191X
AD  - Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu 
      Road West, Guangzhou, 510632 Guangdong, China.
FAU - Zeng, Yu-Fei
AU  - Zeng YF
AD  - Department of Obstetrics and Gynecology, Shangrao Fifth People's Hospital, 
      Shangrao, Jiangxi 334000, China.
FAU - Gao, Xu-Ping
AU  - Gao XP
AUID- ORCID: 0000-0003-3813-2036
AD  - Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu 
      Road West, Guangzhou, 510632 Guangdong, China.
FAU - Liu, Yan-Hua
AU  - Liu YH
AD  - The First Affiliated Hospital of Zhengzhou University, No. 1 East Jianshe Road, 
      Zhengzhou, 450052 Henan, China.
FAU - Sun, Wei
AU  - Sun W
AD  - Customs Comprehensive Laboratory, Baiyun International Airport Customs, Hengyi 
      Road, Guangzhou, 510080 Guangdong, China.
FAU - Zhu, Sui
AU  - Zhu S
AD  - Department of Medical Statistics, School of Medicine, Jinan University, No. 601 
      Huangpu Road West, Guangzhou, 510632 Guangdong, China.
FAU - Zeng, Fang-Fang
AU  - Zeng FF
AUID- ORCID: 0000-0001-8650-0927
AD  - Department of Epidemiology, School of Medicine, Jinan University, No. 601 Huangpu 
      Road West, Guangzhou, 510632 Guangdong, China.
FAU - Ye, Yan-Bin
AU  - Ye YB
AUID- ORCID: 0000-0002-1325-1517
AD  - Department of Nutrition, The First Affiliated Hospital of Sun Yat-sen University, 
      58# Zhongshan Road 2, Guangzhou, 510080 Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20200703
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (KCNQ1 Potassium Channel)
SB  - IM
MH  - Alleles
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - KCNQ1 Potassium Channel/*genetics
MH  - *Polymorphism, Single Nucleotide
PMC - PMC7362295
COIS- The authors state that the study was conducted without any commercial or 
      financial relationship.
EDAT- 2020/07/23 06:00
MHDA- 2021/06/10 06:00
PMCR- 2020/07/03
CRDT- 2020/07/23 06:00
PHST- 2019/11/30 00:00 [received]
PHST- 2020/04/10 00:00 [revised]
PHST- 2020/04/28 00:00 [accepted]
PHST- 2020/07/23 06:00 [entrez]
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2021/06/10 06:00 [medline]
PHST- 2020/07/03 00:00 [pmc-release]
AID - 10.1155/2020/7145139 [doi]
PST - epublish
SO  - J Diabetes Res. 2020 Jul 3;2020:7145139. doi: 10.1155/2020/7145139. eCollection 
      2020.