PMID- 32696242
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 127
IP  - 10
DP  - 2020 Oct
TI  - Examination of plasma zonulin levels in bipolar I disorder: a case-control study 
      with follow-up.
PG  - 1419-1426
LID - 10.1007/s00702-020-02234-7 [doi]
AB  - There is an accumulation in studies which strive to reveal zonulin's potential 
      role in mental disorders. To date, one cross-sectional recent study examined 
      zonulin in patients with bipolar disorders (BDs); however, its role still remains 
      vague due to high fluctuation. Our aims are to determine plasma zonulin levels in 
      exacerbation and treatment response periods, and to examine the associations 
      between zonulin and symptom severity in BD. 30 patients with BD type I and 29 
      healthy controls participated in the current study. Socio-demographic form, Young 
      Mania Rating Scale (YMRS), and Hamilton Depression Rating Scale (HAM-D) were 
      administered. Enzyme-linked immune assay (ELISA) method was used to measure the 
      plasma zonulin levels of the participants. The groups did not differ in plasma 
      zonulin-level comparisons. Plasma zonulin did not alter between the exacerbation 
      and treatment response periods of the patients. Besides, no associations were 
      found between plasma zonulin-level and disease symptoms. Intestinal barrier 
      integrity was not found to be altered among patients with BD type I. The lack of 
      alterations in plasma zonulin level between different periods may be attributable 
      to several factors. One possible factor might be the ELISA method which can 
      detect other proteins (e.g., properdin) rather than zonulin. Therefore, it might 
      fail to indicate direct observation of intestinal permeability. However, future 
      study designs with more accurate estimation of zonulin in a larger sample may 
      provide a different perspective on intestinal permeability's possible role in BD 
      etiology.
FAU - Aydin, Orkun
AU  - Aydin O
AUID- ORCID: 0000-0003-0869-7394
AD  - Department of Psychology, International University of Sarajevo, Faculty of Arts 
      and Social Sciences, Hrasnicka cesta 15, Ilidza, 71210, Sarajevo, Bosnia and 
      Herzegovina. oaydin@ius.edu.ba.
FAU - Kocabas, Tugba
AU  - Kocabas T
AD  - Department of Psychiatry, Celal Bayar University, Faculty of Medicine, Manisa, 
      Turkey.
FAU - Sarandol, Asli
AU  - Sarandol A
AD  - Department of Psychiatry, Uludag University, Faculty of Medicine, Bursa, Turkey.
FAU - Tastan, Ismail
AU  - Tastan I
AD  - Department of Biochemistry, Celal Bayar University, Faculty of Medicine, Manisa, 
      Turkey.
FAU - Onur, Ece
AU  - Onur E
AD  - Department of Biochemistry, Celal Bayar University, Faculty of Medicine, Manisa, 
      Turkey.
FAU - Aydemir, Omer
AU  - Aydemir O
AD  - Department of Psychiatry, Celal Bayar University, Faculty of Medicine, Manisa, 
      Turkey.
FAU - Esen-Danaci, Aysen
AU  - Esen-Danaci A
AD  - Department of Psychiatry, Celal Bayar University, Faculty of Medicine, Manisa, 
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200721
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Haptoglobins)
RN  - 0 (Protein Precursors)
RN  - 0 (zonulin)
SB  - IM
MH  - *Bipolar Disorder/diagnosis
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Follow-Up Studies
MH  - Haptoglobins
MH  - Humans
MH  - Protein Precursors
OTO - NOTNLM
OT  - Autoimmune
OT  - Bipolar disorder
OT  - Haptoglobin
OT  - Inflammation
OT  - Symptom severity
OT  - Zonulin
EDAT- 2020/07/23 06:00
MHDA- 2021/10/16 06:00
CRDT- 2020/07/23 06:00
PHST- 2020/05/23 00:00 [received]
PHST- 2020/07/14 00:00 [accepted]
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2020/07/23 06:00 [entrez]
AID - 10.1007/s00702-020-02234-7 [pii]
AID - 10.1007/s00702-020-02234-7 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2020 Oct;127(10):1419-1426. doi: 
      10.1007/s00702-020-02234-7. Epub 2020 Jul 21.