PMID- 32696432
OWN - NLM
STAT- MEDLINE
DCOM- 20201120
LR  - 20201120
IS  - 1179-1969 (Electronic)
IS  - 1170-229X (Linking)
VI  - 37
IP  - 9
DP  - 2020 Sep
TI  - Real-World Effectiveness and Safety of Apremilast in Older Patients with 
      Psoriasis.
PG  - 657-663
LID - 10.1007/s40266-020-00781-y [doi]
AB  - INTRODUCTION: Apremilast is a drug recently developed for psoriasis. Few data are 
      available on its use in the elderly. We evaluated the tolerance and effectiveness 
      of apremilast used in daily practice for psoriasis treatment in older patients. 
      METHODS: We performed a multicenter, retrospective study involving patients 
      aged >/= 65 years who had received apremilast as a psoriasis treatment. Demographic 
      data and details regarding psoriasis and adverse events (AEs) were collected from 
      patient medical records. RESULTS: 135 patients were included (mean age: 
      73.5 years). Treatment was stopped in 74 patients (54.8%) for AEs (n = 43, 
      56.6%), primary failures (n = 18, 23.4%), and relapses (n = 7, 9.2%). When 
      patients were stratified by age at treatment initiation, the main cause of 
      discontinuation in patients >/= 75 years was AEs, whereas in patients aged 
      65-74 years it was primary failures (28.3%). Sixty-one patients reported AEs, 
      mainly digestive (n = 49). Regarding effectiveness, 45.2% of patients reached PGA 
      0/1 between 3 and 6 months after treatment initiation. One-year apremilast 
      continuation rates were better in the 65-74 and 75-84 years subgroups than in 
      the > 85 years subgroup (p = 0.01). CONCLUSION: Apremilast seems to be an 
      effective and safe therapeutic option for psoriasis in the elderly. The main AEs 
      reported by patients did not seem to differ from those reported previously in 
      younger populations. However, AEs were more frequent in patients > 75 years old 
      leading to more frequent discontinuation of apremilast compared with younger 
      patients, suggesting a higher level of vigilance is needed in the elderly.
FAU - Phan, Celine
AU  - Phan C
AUID- ORCID: 0000-0001-7315-9600
AD  - Service de Dermatologie, Hopital Victor Dupouy, 69 rue du Lieutenant-Colonel 
      Prud'hon, 95100, Argenteuil, France. celine.phan@ch-argenteuil.fr.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France. celine.phan@ch-argenteuil.fr.
FAU - Beneton, Nathalie
AU  - Beneton N
AD  - Service de Dermatologie, Centre Hospitalier du Mans, Le Mans, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Delaunay, Juliette
AU  - Delaunay J
AD  - Service de Dermatologie, CHU Angers, Angers, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Reguiai, Ziad
AU  - Reguiai Z
AD  - Service de Dermatologie, Polyclinique Courlancy, Reims, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Boulard, Claire
AU  - Boulard C
AD  - Service de Dermatologie, Hopital Jacques Monod, Le Havre, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Fougerousse, Anne-Claire
AU  - Fougerousse AC
AD  - Service de Dermatologie, Hopital d'Instruction des Armees Begin, Saint Mande, 
      France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Cinotti, Elisa
AU  - Cinotti E
AD  - Dermatology Department, Dipartimento di Scienze Mediche, Chirurgiche e 
      Neuroscienze, A.O.U.S. Le Scotte, Universitadegli Studi di Siena, Siena, Italy.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Romanelli, Marco
AU  - Romanelli M
AD  - Dermatology Department, Universita de Pisa, Pisa, Italy.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Mery-Bossard, Laure
AU  - Mery-Bossard L
AD  - Service de Dermatologie, Centre Hospitalier Intercommunal de 
      Poissy/Saint-Germain-en-Laye, Saint-Germain-en-Laye, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Thomas-Beaulieu, Domitille
AU  - Thomas-Beaulieu D
AD  - Service de Dermatologie, Centre Hospitalier Intercommunal de 
      Poissy/Saint-Germain-en-Laye, Saint-Germain-en-Laye, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Parier, Josiane
AU  - Parier J
AD  - Private Office, La Varenne, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Maccari, Francois
AU  - Maccari F
AD  - Private Office, La Varenne, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Chaby, Guillaume
AU  - Chaby G
AD  - Service de Dermatologie, Hopital Sud, Avenue Laennec, 80054, Amiens Cedex 1, 
      France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Bastien, Marie
AU  - Bastien M
AD  - Private Office, 5 Joinville le Pont, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Begon, Edouard
AU  - Begon E
AD  - Service de Dermatologie, Hopital de Pontoise, Pontoise, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Samimi, Mahtab
AU  - Samimi M
AD  - Service de Dermatologie, Polyclinique Courlancy, Reims, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
FAU - Prignano, Francesca
AU  - Prignano F
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
AD  - Dermatology Department, Florence, Italy.
FAU - Beauchet, Alain
AU  - Beauchet A
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
AD  - Departement de Sante Publique, Centre Hospitalier Universitaire Ambroise Pare, 
      Assistance Publique-Hopitaux de Paris, Boulogne-Billancourt, France.
FAU - Mahe, Emmanuel
AU  - Mahe E
AD  - Service de Dermatologie, Hopital Victor Dupouy, 69 rue du Lieutenant-Colonel 
      Prud'hon, 95100, Argenteuil, France.
AD  - Service de Dermatologie, Centre Hospitalier Universitaire de Tours, Tours, 
      France.
CN  - GEM Resopso
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - New Zealand
TA  - Drugs Aging
JT  - Drugs & aging
JID - 9102074
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Phosphodiesterase 4 Inhibitors)
RN  - 4Z8R6ORS6L (Thalidomide)
RN  - UP7QBP99PN (apremilast)
SB  - IM
MH  - Administration, Oral
MH  - Age Factors
MH  - Aged
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Medical Records
MH  - Middle Aged
MH  - Phosphodiesterase 4 Inhibitors/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Psoriasis/*drug therapy
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Thalidomide/administration & dosage/adverse effects/*analogs & 
      derivatives/therapeutic use
MH  - Treatment Outcome
FIR - Perrot, Jean-Luc
IR  - Perrot JL
FIR - Ruer-Mulard, Mireille
IR  - Ruer-Mulard M
FIR - Jacobzone, Caroline
IR  - Jacobzone C
FIR - Quiles-Tsimaratos, Nathalie
IR  - Quiles-Tsimaratos N
FIR - Descamps, Vincent
IR  - Descamps V
FIR - Steff, Maud
IR  - Steff M
FIR - Bilan, Paul
IR  - Bilan P
FIR - Vermersch-Langlin, Annie
IR  - Vermersch-Langlin A
FIR - Kemula, Mathilde
IR  - Kemula M
FIR - Amazan, Emmanuelle
IR  - Amazan E
FIR - Kupfer-Bessaguet, Ingrid
IR  - Kupfer-Bessaguet I
FIR - Cottencin, Anne-Caroline
IR  - Cottencin AC
FIR - Livideanu, Bulai
IR  - Livideanu B
FIR - Gottlieb, Jeremy
IR  - Gottlieb J
EDAT- 2020/07/23 06:00
MHDA- 2020/11/21 06:00
CRDT- 2020/07/23 06:00
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2020/11/21 06:00 [medline]
PHST- 2020/07/23 06:00 [entrez]
AID - 10.1007/s40266-020-00781-y [pii]
AID - 10.1007/s40266-020-00781-y [doi]
PST - ppublish
SO  - Drugs Aging. 2020 Sep;37(9):657-663. doi: 10.1007/s40266-020-00781-y.