PMID- 32696574
OWN - NLM
STAT- MEDLINE
DCOM- 20201127
LR  - 20201127
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 62
IP  - 4
DP  - 2020 Oct
TI  - Identifying putative cerebrospinal fluid biomarkers of amyotrophic lateral 
      sclerosis in a north Indian population.
PG  - 528-533
LID - 10.1002/mus.27026 [doi]
AB  - INTRODUCTION: Evidence-based information about cerebrospinal fluid (CSF) levels 
      of biomarkers in patients with amyotrophic lateral sclerosis (ALS) is limited. 
      METHODS: Vascular endothelial growth factor (VEGF) and its receptor vascular 
      endothelial growth factor receptor 2 (VEGFR2), optineurin (OPTN), monocyte 
      chemoattractant protein-1 (MCP-1), angiogenin (ANG), and TAR DNA-binding protein 
      (TDP-43) were quantified by enzyme-linked immunoassay in the CSF of 54 patients 
      with sporadic ALS and 32 controls in a case-control study design. RESULTS: CSF 
      levels of VEGF (P = .014) and ANG (P = .009) were decreased, whereas VEGFR2 was 
      higher (P = .002) in patients with ALS than in controls. TDP-43 positively 
      correlated with MCP-1 (P = .003), VEGF (P < .001), and VEGFR2 (P < .001) in 
      patients with ALS. DISCUSSION: Our findings suggest possible utility of VEGF, 
      VEGFR2, and ANG as biomarkers for use in ALS treatment trials.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Khosla, Radhika
AU  - Khosla R
AD  - Neuroscience Research Lab, PGIMER, Chandigarh, India.
FAU - Rain, Manjari
AU  - Rain M
AD  - Neuroscience Research Lab, PGIMER, Chandigarh, India.
FAU - Chawathey, Shreyas
AU  - Chawathey S
AD  - D. Y. Patil University School of Medicine, Navi Mumbai, India.
FAU - Modgil, Shweta
AU  - Modgil S
AD  - Neuroscience Research Lab, PGIMER, Chandigarh, India.
FAU - Tyagi, Rahul
AU  - Tyagi R
AD  - Neuroscience Research Lab, PGIMER, Chandigarh, India.
FAU - Thakur, Keshav
AU  - Thakur K
AD  - Neuroscience Research Lab, PGIMER, Chandigarh, India.
FAU - Pannu, Viraaj
AU  - Pannu V
AUID- ORCID: 0000-0001-6315-0186
AD  - Government Medical College and Hospital, Chandigarh, India.
FAU - Sharma, Suresh Kumar
AU  - Sharma SK
AD  - Department of Statistics, Panjab University, Chandigarh, India.
FAU - Anand, Akshay
AU  - Anand A
AUID- ORCID: 0000-0001-9003-3532
AD  - Neuroscience Research Lab, PGIMER, Chandigarh, India.
LA  - eng
GR  - 5/4-5/122Neuro/2013-NCD-I/Indian Council of Medical Research/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200813
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (OPTN protein, human)
RN  - 0 (TARDBP protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
RN  - EC 3.1.27.- (angiogenin)
RN  - EC 3.1.27.5 (Ribonuclease, Pancreatic)
SB  - IM
MH  - Adult
MH  - Amyotrophic Lateral Sclerosis/cerebrospinal fluid/*diagnosis
MH  - Biomarkers/cerebrospinal fluid
MH  - Case-Control Studies
MH  - Cell Cycle Proteins/*cerebrospinal fluid
MH  - Chemokine CCL2/*cerebrospinal fluid
MH  - DNA-Binding Proteins/*cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - India
MH  - Male
MH  - Membrane Transport Proteins/*cerebrospinal fluid
MH  - Middle Aged
MH  - Ribonuclease, Pancreatic/*cerebrospinal fluid
MH  - Vascular Endothelial Growth Factor A/*cerebrospinal fluid
MH  - Vascular Endothelial Growth Factor Receptor-2/*cerebrospinal fluid
OTO - NOTNLM
OT  - amyotrophic lateral sclerosis, angiogenesis, cerebrospinal fluid, muscle wasting, 
      neuromuscular disorder
EDAT- 2020/07/23 06:00
MHDA- 2020/11/28 06:00
CRDT- 2020/07/23 06:00
PHST- 2019/12/29 00:00 [received]
PHST- 2020/07/15 00:00 [revised]
PHST- 2020/07/18 00:00 [accepted]
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2020/11/28 06:00 [medline]
PHST- 2020/07/23 06:00 [entrez]
AID - 10.1002/mus.27026 [doi]
PST - ppublish
SO  - Muscle Nerve. 2020 Oct;62(4):528-533. doi: 10.1002/mus.27026. Epub 2020 Aug 13.