PMID- 32696658
OWN - NLM
STAT- MEDLINE
DCOM- 20201014
LR  - 20221207
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
VI  - 71
IP  - 10
DP  - 2020 Nov
TI  - Does the Carotid Bulb Offer a Better 10-Year CVD/Stroke Risk Assessment Compared 
      to the Common Carotid Artery? A 1516 Ultrasound Scan Study.
PG  - 920-933
LID - 10.1177/0003319720941730 [doi]
AB  - The objectives of this study are to (1) examine the "10-year cardiovascular risk" 
      in the common carotid artery (CCA) versus carotid bulb using an integrated 
      calculator called "AtheroEdge Composite Risk Score 2.0" (AECRS2.0) and (2) 
      evaluate the performance of AECRS2.0 against "conventional cardiovascular risk 
      calculators." These objectives are met by measuring (1) image-based phenotypes 
      and AECRS2.0 score computation and (2) performance evaluation of AECRS2.0 against 
      12 conventional cardiovascular risk calculators. The Asian-Indian cohort (n = 
      379) with type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD), or 
      hypertension were retrospectively analyzed by acquiring the 1516 carotid 
      ultrasound scans (mean age: 55 +/- 10.1 years, 67% males,  approximately 92% with T2DM,  approximately 83% with 
      CKD [stage 1-5], and 87.5% with hypertension [stage 1-2]). The carotid bulb 
      showed a higher 10-year cardiovascular risk compared to the CCA by 18% (P < 
      .0001). Patients with T2DM and/or CKD also followed a similar trend. The carotid 
      bulb demonstrated a superior risk assessment compared to CCA in patients with 
      T2DM and/or CKD by showing: (1)  approximately 13% better than CCA (0.93 vs 0.82, P = .0001) 
      and (2)  approximately 29% better compared with 12 types of risk conventional calculators (0.93 
      vs 0.72, P = .06).
FAU - Viswanathan, Vijay
AU  - Viswanathan V
AD  - 58896Moopil Viswanathan Hospital for Diabetes and Professor M Viswanathan 
      Diabetes Research Centre, Chennai, Tamil Nadu, India.
FAU - Jamthikar, Ankush D
AU  - Jamthikar AD
AD  - Department of Electronics and Communication Engineering, 29583Visvesvaraya 
      National Institute of Technology, Nagpur, Maharashtra, India.
FAU - Gupta, Deep
AU  - Gupta D
AD  - Department of Electronics and Communication Engineering, 29583Visvesvaraya 
      National Institute of Technology, Nagpur, Maharashtra, India.
FAU - Puvvula, Anudeep
AU  - Puvvula A
AD  - Annu's Hospitals for Skin and Diabetes, Nellore, Andhra Pradesh, India.
FAU - Khanna, Narendra N
AU  - Khanna NN
AD  - Department of Cardiology, 75911Indraprastha APOLLO Hospitals, New Delhi, India.
FAU - Saba, Luca
AU  - Saba L
AD  - Department of Radiology, University of Cagliari, Cagliari, Italy.
FAU - Viskovic, Klaudija
AU  - Viskovic K
AD  - Department of Radiology and Ultrasound, University Hospital for Infectious 
      Diseases, Zagreb, Croatia.
FAU - Mavrogeni, Sophie
AU  - Mavrogeni S
AD  - Cardiology Clinic, Onassis Cardiac Surgery Center, Athens, Greece.
FAU - Laird, John R
AU  - Laird JR
AD  - Heart and Vascular Institute, Adventist Health St. Helena, St Helena, CA, USA.
FAU - Pareek, Gyan
AU  - Pareek G
AD  - Minimally Invasive Urology Institute, 6752Brown University, Providence, RI, USA.
FAU - Miner, Martin
AU  - Miner M
AD  - Men's Health Center, Miriam Hospital Providence, Providence, RI, USA.
FAU - Sfikakis, Petros P
AU  - Sfikakis PP
AD  - Rheumatology Unit, 68993National and Kapodistrian University of Athens, Athens, 
      Greece.
FAU - Protogerou, Athanasios
AU  - Protogerou A
AD  - Department of Cardiovascular Prevention & Research Unit Clinic & Laboratory of 
      Pathophysiology, 68993National and Kapodistrian University of Athens, Athens, 
      Greece.
FAU - Sharma, Aditya
AU  - Sharma A
AD  - Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, 
      USA.
FAU - Kancharana, Priyanka
AU  - Kancharana P
AD  - 58896Moopil Viswanathan Hospital for Diabetes and Professor M Viswanathan 
      Diabetes Research Centre, Chennai, Tamil Nadu, India.
FAU - Misra, Durga Prasanna
AU  - Misra DP
AD  - Department of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
FAU - Agarwal, Vikas
AU  - Agarwal V
AD  - Department of Clinical Immunology and Rheumatology, SGPGIMS, Lucknow, India.
FAU - Kitas, George D
AU  - Kitas GD
AD  - R & D Academic Affairs, 7714Dudley Group NHS Foundation Trust, Dudley, UK.
FAU - Nicolaides, Andrew
AU  - Nicolaides A
AD  - Vascular Screening and Diagnostic Centre and University of Nicosia Medical 
      School, Nicosia, Cyprus.
FAU - Suri, Jasjit S
AU  - Suri JS
AUID- ORCID: 0000-0001-6499-396X
AD  - Stroke Monitoring and Diagnostic Division, AtheroPoint, Roseville, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20200722
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Carotid Artery, Common/*diagnostic imaging
MH  - *Carotid Intima-Media Thickness
MH  - Diabetes Mellitus, Type 2/complications/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Hypertension/complications/*diagnostic imaging
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Renal Insufficiency, Chronic/complications/*diagnostic imaging
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Stroke/*epidemiology
OTO - NOTNLM
OT  - 10-year risk
OT  - atherosclerosis
OT  - cardiovascular risk
OT  - carotid bulb
OT  - chronic kidney disease
OT  - common carotid artery
OT  - risk assessment
OT  - type 2 diabetes
EDAT- 2020/07/23 06:00
MHDA- 2020/10/21 06:00
CRDT- 2020/07/23 06:00
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2020/07/23 06:00 [entrez]
AID - 10.1177/0003319720941730 [doi]
PST - ppublish
SO  - Angiology. 2020 Nov;71(10):920-933. doi: 10.1177/0003319720941730. Epub 2020 Jul 
      22.