PMID- 32696856 OWN - NLM STAT- MEDLINE DCOM- 20201204 LR - 20220816 IS - 1678-4170 (Electronic) IS - 0066-782X (Print) IS - 0066-782X (Linking) VI - 115 IP - 3 DP - 2020 Sep TI - Depressive Symptoms are Associated with High Levels of Serum Low-Density Lipoprotein Cholesterol in Older Adults with Type 2 Diabetes Mellitus. PG - 462-467 LID - 10.36660/abc.20190404 [doi] AB - BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is common in older adults, who also present a high level of risk factors for cardiovascular disease (CVD), such as dyslipidemia. However, the role of depression in T2DM patients and its relationship with CVD risk factors are understudied. OBJECTIVE: The present study aimed to investigate the relationship between depressive symptoms (DS) and known cardiovascular risk factors in community dwelling older adults with T2DM. METHODS: This is a cross sectional study, in which 85 community-dwelling older adults with T2DM were assessed. DS was assessed using the Yesavage Geriatric Depression Scale - short version (GDS-15). The following cardiovascular risk factors were evaluated: systolic (SBP) and diastolic blood pressure (DBP), fasting plasma glucose (FPG), lipid profile (serum triglycerides - TG, serum total cholesterol - TC, serum low-density lipoprotein cholesterol - LDL-C, and serum high-density lipoprotein cholesterol - HDL-C) and body mass index (BMI). Poisson multiple regression was performed to test the association between DS and each cardiovascular risk factor adjusted by sex, age, time spent in moderate physical activity, and functional status. The significance level adopted for the analysis was 5%. RESULTS: Among all the analyzed risk factors, only high levels of LDL-C were related to high DS (PR=1.005, CI 95% 1.002-1.008). A significant association was observed between HDL-C levels (PR=0.99, CI 95% 0.98-0.99) and SBP (PR=1.009, CI 95% 1.004-1.014). CONCLUSION: In older adults with T2DM, the presence of DS was associated with LDL-C, HDL-C levels and SBP, even after adjusting for sex, age, physical activity level and functional capacity. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0). FAU - Fittipaldi, Etiene Oliveira da Silva AU - Fittipaldi EODS AUID- ORCID: 0000-0002-1524-6930 AD - Universidade Federal de Pernambuco, Recife, PE - Brasil. FAU - Andrade, Armele Dornelas de AU - Andrade AD AD - Universidade Federal de Pernambuco, Recife, PE - Brasil. FAU - Santos, Ana Celia Oliveira AU - Santos ACO AD - Universidade de Pernambuco, Recife, PE-Brasil. FAU - Campos, Shirley AU - Campos S AD - Universidade Federal de Pernambuco, Recife, PE - Brasil. FAU - Fernandes, Juliana AU - Fernandes J AUID- ORCID: 0000-0002-7509-8853 AD - Universidade Federal de Pernambuco, Recife, PE - Brasil. FAU - Catanho, Maria Teresa Jansen de Almeida AU - Catanho MTJA AD - Universidade Federal de Pernambuco, Recife, PE - Brasil. LA - eng LA - por PT - Journal Article PT - Research Support, Non-U.S. Gov't TT - Sintomas Depressivos estao Associados a Niveis Sericos Elevados de Colesterol de Lipoproteina de Baixa Densidade em Idosos com Diabetes Mellitus Tipo 2. PL - Brazil TA - Arq Bras Cardiol JT - Arquivos brasileiros de cardiologia JID - 0421031 RN - 0 (Cholesterol, HDL) RN - 0 (Cholesterol, LDL) RN - 0 (Triglycerides) SB - IM MH - Aged MH - Cholesterol, HDL MH - Cholesterol, LDL MH - Cross-Sectional Studies MH - *Depression/etiology MH - *Diabetes Mellitus, Type 2/complications MH - Humans MH - Risk Factors MH - Triglycerides PMC - PMC9363090 OAB - BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is common in older adults, who also present a high level of risk factors for cardiovascular disease (CVD), such as dyslipidemia. However, the role of depression in T2DM patients and its relationship with CVD risk factors are understudied. OBJECTIVE: The present study aimed to investigate the relationship between depressive symptoms (DS) and known cardiovascular risk factors in community dwelling older adults with T2DM. METHODS: This is a cross sectional study, in which 85 community-dwelling older adults with T2DM were assessed. DS was assessed using the Yesavage Geriatric Depression Scale - short version (GDS-15). The following cardiovascular risk factors were evaluated: systolic (SBP) and diastolic blood pressure (DBP), fasting plasma glucose (FPG), lipid profile (serum triglycerides - TG, serum total cholesterol - TC, serum low-density lipoprotein cholesterol - LDL-C, and serum high-density lipoprotein cholesterol - HDL-C) and body mass index (BMI). Poisson multiple regression was performed to test the association between DS and each cardiovascular risk factor adjusted by sex, age, time spent in moderate physical activity, and functional status. The significance level adopted for the analysis was 5%. RESULTS: Among all the analyzed risk factors, only high levels of LDL-C were related to high DS (PR=1.005, CI 95% 1.002-1.008). A significant association was observed between HDL-C levels (PR=0.99, CI 95% 0.98-0.99) and SBP (PR=1.009, CI 95% 1.004-1.014). CONCLUSION: In older adults with T2DM, the presence of DS was associated with LDL-C, HDL-C levels and SBP, even after adjusting for sex, age, physical activity level and functional capacity. (Arq Bras Cardiol. 2020; 115(3):462-467) OABL- eng COIS- Potencial Conflito de Interesses Declaro nao haver conflito de interesses pertinentes. EDAT- 2020/07/23 06:00 MHDA- 2020/12/15 06:00 PMCR- 2020/09/18 CRDT- 2020/07/23 06:00 PHST- 2019/06/23 00:00 [received] PHST- 2019/08/18 00:00 [accepted] PHST- 2020/07/23 06:00 [pubmed] PHST- 2020/12/15 06:00 [medline] PHST- 2020/07/23 06:00 [entrez] PHST- 2020/09/18 00:00 [pmc-release] AID - S0066-782X2020005009204 [pii] AID - abc.20190404 [pii] AID - 10.36660/abc.20190404 [doi] PST - ppublish SO - Arq Bras Cardiol. 2020 Sep;115(3):462-467. doi: 10.36660/abc.20190404.