PMID- 32698105
OWN - NLM
STAT- MEDLINE
DCOM- 20210317
LR  - 20210317
IS  - 1525-5069 (Electronic)
IS  - 1525-5050 (Linking)
VI  - 111
DP  - 2020 Oct
TI  - Resting-state functional MRI of the default mode network in epilepsy.
PG  - 107308
LID - S1525-5050(20)30487-X [pii]
LID - 10.1016/j.yebeh.2020.107308 [doi]
AB  - The default mode network (DMN) is a major neuronal network that deactivates 
      during goal-directed tasks. Recent advances in neuroimaging have shed light on 
      its structure and function. Alterations in the DMN are increasingly recognized in 
      a range of neurological and psychiatric conditions including epilepsy. This 
      review first describes the current understanding of the DMN in health, normal 
      aging, and disease as it is acquired via resting-state functional magnetic 
      resonance imaging (MRI), before focusing on how it is affected in various types 
      of focal and generalized epilepsy. These findings support the potential use of 
      DMN parameters as future biomarkers in epilepsy research, diagnosis, and 
      management.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Gonen, Ofer M
AU  - Gonen OM
AD  - The Royal Melbourne Hospital, VIC, Australia; The University of Melbourne, VIC, 
      Australia; The Alfred Hospital, VIC, Australia. Electronic address: 
      Ofer.Gonen@mh.org.au.
FAU - Kwan, Patrick
AU  - Kwan P
AD  - The Royal Melbourne Hospital, VIC, Australia; The University of Melbourne, VIC, 
      Australia; The Alfred Hospital, VIC, Australia; Monash University, VIC, 
      Australia.
FAU - O'Brien, Terence J
AU  - O'Brien TJ
AD  - The Royal Melbourne Hospital, VIC, Australia; The University of Melbourne, VIC, 
      Australia; The Alfred Hospital, VIC, Australia; Monash University, VIC, 
      Australia.
FAU - Lui, Elaine
AU  - Lui E
AD  - The Royal Melbourne Hospital, VIC, Australia; The University of Melbourne, VIC, 
      Australia.
FAU - Desmond, Patricia M
AU  - Desmond PM
AD  - The Royal Melbourne Hospital, VIC, Australia; The University of Melbourne, VIC, 
      Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200719
PL  - United States
TA  - Epilepsy Behav
JT  - Epilepsy & behavior : E&B
JID - 100892858
SB  - IM
MH  - Brain/*diagnostic imaging/physiopathology
MH  - Brain Mapping/methods
MH  - Default Mode Network/*diagnostic imaging/physiopathology
MH  - Epilepsy/*diagnostic imaging/physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Net/diagnostic imaging/physiopathology
MH  - *Rest/physiology
OTO - NOTNLM
OT  - Default mode network
OT  - Epilepsy
OT  - Functional connectivity
OT  - Resting-state fMRI
COIS- Declaration of competing interest None.
EDAT- 2020/07/23 06:00
MHDA- 2021/03/18 06:00
CRDT- 2020/07/23 06:00
PHST- 2020/04/26 00:00 [received]
PHST- 2020/06/28 00:00 [revised]
PHST- 2020/06/28 00:00 [accepted]
PHST- 2020/07/23 06:00 [pubmed]
PHST- 2021/03/18 06:00 [medline]
PHST- 2020/07/23 06:00 [entrez]
AID - S1525-5050(20)30487-X [pii]
AID - 10.1016/j.yebeh.2020.107308 [doi]
PST - ppublish
SO  - Epilepsy Behav. 2020 Oct;111:107308. doi: 10.1016/j.yebeh.2020.107308. Epub 2020 
      Jul 19.