PMID- 32698682
OWN - NLM
STAT- MEDLINE
DCOM- 20210517
LR  - 20211204
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 84
IP  - 11
DP  - 2020 Nov
TI  - Acute effects of lactic acid-fermented and enzyme-digested soybean on protein 
      synthesis via mTOR signaling in the skeletal muscle.
PG  - 2360-2366
LID - 10.1080/09168451.2020.1795810 [doi]
AB  - Protein-containing nutrients result in the efficient hypertrophy of muscles by 
      increasing muscle protein synthesis. Soybean is often ingested by athletes or 
      individuals who exercise; however, it takes very long to be absorbed. Lactic 
      acid-fermented and enzyme-digested (LFED) soybean is absorbed faster than 
      untreated soybean. This study aims at determining muscle protein synthesis after 
      ingesting a single bolus of soybean or LFED soybean produced by lactic acid 
      bacteria and protease digestion. Eight-week-old overnight-fasted ICR mice were 
      administered powdered or LFED soybean. Mice were euthanized at 7, 15, 30, 60, 90, 
      and 120 min after soybean intake. We have demonstrated that LFED soybean 
      administration was quicker in stimulating muscle protein synthesis by activating 
      mammalian target of rapamycin (mTOR) signaling than orally ingesting untreated 
      soybean in the gastrocnemius muscle. These results suggested that LFED soybean is 
      a more efficient source of nutrition for muscle hypertrophy than untreated 
      soybean.
FAU - Ono, Kohei
AU  - Ono K
AD  - Department of Rehabilitation Science, Kobe University Graduate School of Health 
      Sciences , Kobe, Japan.
FAU - Tanaka, Minoru
AU  - Tanaka M
AUID- ORCID: 0000-0002-7009-7851
AD  - Department of Rehabilitation Science, Kobe University Graduate School of Health 
      Sciences , Kobe, Japan.
AD  - Department of Rehabilitation Science, Osaka Health Science University , Osaka, 
      Japan.
FAU - Ikeji, Takuya
AU  - Ikeji T
AD  - Department of Rehabilitation Science, Kobe University Graduate School of Health 
      Sciences , Kobe, Japan.
FAU - Nakanishi, Ryosuke
AU  - Nakanishi R
AD  - Department of Rehabilitation Science, Kobe University Graduate School of Health 
      Sciences , Kobe, Japan.
AD  - Faculty of Rehabilitation, Department of Physical Therapy, Kobe International 
      University , Kobe, Japan.
FAU - Hirabayashi, Takumi
AU  - Hirabayashi T
AD  - Department of Rehabilitation Science, Kobe University Graduate School of Health 
      Sciences , Kobe, Japan.
FAU - Tategaki, Airo
AU  - Tategaki A
AD  - Pharma & Supplemental Nutrition Solurtions Vehicle Biotechnology Research 
      Laboratories, Kaneka Corporation , Takasago, Japan.
FAU - Kondo, Hiroyo
AU  - Kondo H
AD  - Department of Rehabilitation Science, Kobe University Graduate School of Health 
      Sciences , Kobe, Japan.
AD  - Department of Food Science and Nutrition, Nagoya Women's University , Nagoya, 
      Japan.
FAU - Ishihara, Akihiko
AU  - Ishihara A
AD  - Graduate School of Human and Environmental Studies, Kyoto University , Kyoto, 
      Japan.
FAU - Fujino, Hidemi
AU  - Fujino H
AD  - Department of Rehabilitation Science, Kobe University Graduate School of Health 
      Sciences , Kobe, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200722
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Soybean Proteins)
RN  - 33X04XA5AT (Lactic Acid)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 3.4.- (Peptide Hydrolases)
SB  - IM
MH  - Animals
MH  - *Digestion
MH  - Lactic Acid/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Muscle, Skeletal/anatomy & histology/*cytology/drug effects
MH  - Organ Size/drug effects
MH  - Peptide Hydrolases/*metabolism
MH  - Signal Transduction/*drug effects
MH  - Soybean Proteins/metabolism/*pharmacology
MH  - TOR Serine-Threonine Kinases/*metabolism
OTO - NOTNLM
OT  - Soybean
OT  - lactic acid-fermented and enzyme-digested soybean
OT  - mTOR pathway
OT  - muscle protein synthesis
OT  - ribosomal protein S6
EDAT- 2020/07/24 06:00
MHDA- 2021/05/18 06:00
CRDT- 2020/07/24 06:00
PHST- 2020/07/24 06:00 [pubmed]
PHST- 2021/05/18 06:00 [medline]
PHST- 2020/07/24 06:00 [entrez]
AID - 10.1080/09168451.2020.1795810 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2020 Nov;84(11):2360-2366. doi: 
      10.1080/09168451.2020.1795810. Epub 2020 Jul 22.