PMID- 32700409 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20221110 IS - 2055-5822 (Electronic) IS - 2055-5822 (Linking) VI - 7 IP - 6 DP - 2020 Dec TI - The impact of pharmacist/physician care on quality of life in elderly heart failure patients: results of the PHARM-CHF randomized controlled trial. PG - 3310-3319 LID - 10.1002/ehf2.12904 [doi] AB - AIMS: Patients with heart failure (HF) have impaired quality of life (QoL). The randomized controlled trial PHARM-CHF investigated whether an interdisciplinary intervention consisting of regular contacts with the community pharmacy and weekly dosing aids improves medication adherence in patients with HF. It is unknown how an intervention involving frequent structured pharmacy visits affects QoL. Our aim was to explore adherence to the intervention and effects on QoL. METHODS AND RESULTS: Among 237 patients, n = 110 were randomized to pharmacy care and n = 127 to usual care. The pharmacy care group received a medication review followed by (bi-)weekly dose dispensing and counselling. The median follow-up was 2.0 years [inter-quartile range (IQR) 1.2-2.7]. Median interval between pharmacy visits was 8.4 days (IQR 8.0-10.3) and the visits lasted in median 14 min (IQR 10-15). Median adherence to the intervention was 96% (IQR 84-100). QoL at 365 days was predefined as a main secondary and at 730 days as another secondary endpoint in PHARM-CHF. QoL was measured by the Minnesota Living with Heart Failure Questionnaire; and for 111 patients (n = 47 in the pharmacy care group and n = 64 in the usual care group), data were available at baseline, and after 365 and 730 days (mean age 74 years; 41% female). Improvement in QoL was numerically higher in the pharmacy care group after 365 days and was significantly better after 730 days (difference in total scores -7.7 points [-14.5 to -1.0]; P = 0.026) compared to the usual care group. In all subgroups examined, this treatment effect was preserved. Improvements in the physical and emotional dimensions were numerically higher in the pharmacy care group after 365 days and were significantly better after 730 days: -4.0 points [-6.9 to -1.2]; P = 0.006, and -1.9 points [-3.7 to -0.1]; P = 0.039, respectively. CONCLUSIONS: A pharmacy-based interdisciplinary intervention was well received by the patients and suggests clinically important improvements in QoL. CI - (c) 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. FAU - Schulz, Martin AU - Schulz M AUID- ORCID: 0000-0002-5876-7322 AD - Department of Medicine, ABDA - Federal Union of German Associations of Pharmacists, Berlin, Germany. AD - Institute of Pharmacy, Freie Universitat Berlin, Berlin, Germany. FAU - Griese-Mammen, Nina AU - Griese-Mammen N AD - Department of Medicine, ABDA - Federal Union of German Associations of Pharmacists, Berlin, Germany. FAU - Schumacher, Pia M AU - Schumacher PM AD - Department of Medicine, ABDA - Federal Union of German Associations of Pharmacists, Berlin, Germany. FAU - Anker, Stefan D AU - Anker SD AD - Division of Cardiology and Metabolism, Department of Cardiology (CVK) and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), German Centre for Cardiovascular Research (DZHK) Partner Site Berlin, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Koehler, Friedrich AU - Koehler F AD - Centre for Cardiovascular Telemedicine, Department of Cardiology and Angiology, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Ruckes, Christian AU - Ruckes C AD - Interdisciplinary Centre for Clinical Trials, University Medical Centre Mainz, Mainz, Germany. FAU - Rettig-Ewen, Volker AU - Rettig-Ewen V AD - Schwemlinger Gemeinschaftspraxis, Merzig, Germany. FAU - Wachter, Rolf AU - Wachter R AD - Department of Cardiology, University Hospital, Leipzig University, Leipzig, Germany. FAU - Trenk, Dietmar AU - Trenk D AD - Department of Clinical Pharmacology, University Heart Centre Freiburg-Bad Krozingen, Bad Krozingen, Germany. FAU - Bohm, Michael AU - Bohm M AD - Department of Internal Medicine III - Cardiology, Angiology and Intensive Care Medicine, University Hospital of Saarland, Saarland University, Homburg/Saar, Germany. FAU - Laufs, Ulrich AU - Laufs U AD - Department of Cardiology, University Hospital, Leipzig University, Leipzig, Germany. LA - eng GR - Foundation Pharmaceutical Care Berlin/ GR - Lesmueller Foundation/ GR - Chamber of Pharmacists North Rhine/ GR - Apotheker-Foundation Westphalia-Lippe/ GR - ABDA - Federal Union of German Associations of Pharmacists/ PT - Journal Article DEP - 20200723 PL - England TA - ESC Heart Fail JT - ESC heart failure JID - 101669191 SB - IM PMC - PMC7754956 OTO - NOTNLM OT - Chronic heart failure OT - Community pharmacy services OT - Health-related quality of life OT - Interdisciplinary care OT - Randomized controlled trial COIS- None to declare. EDAT- 2020/07/24 06:00 MHDA- 2020/07/24 06:01 PMCR- 2020/07/23 CRDT- 2020/07/24 06:00 PHST- 2020/06/10 00:00 [revised] PHST- 2020/04/02 00:00 [received] PHST- 2020/07/13 00:00 [accepted] PHST- 2020/07/24 06:00 [pubmed] PHST- 2020/07/24 06:01 [medline] PHST- 2020/07/24 06:00 [entrez] PHST- 2020/07/23 00:00 [pmc-release] AID - EHF212904 [pii] AID - 10.1002/ehf2.12904 [doi] PST - ppublish SO - ESC Heart Fail. 2020 Dec;7(6):3310-3319. doi: 10.1002/ehf2.12904. Epub 2020 Jul 23.