PMID- 32700588
OWN - NLM
STAT- MEDLINE
DCOM- 20210204
LR  - 20221207
IS  - 1744-764X (Electronic)
IS  - 1474-0338 (Linking)
VI  - 19
IP  - 10
DP  - 2020 Oct
TI  - The HLA-B*13:01 and the dapsone hypersensitivity syndrome in Korean and Asian 
      populations: genotype- and meta-analyses.
PG  - 1349-1356
LID - 10.1080/14740338.2020.1796965 [doi]
AB  - BACKGROUND: The human leukocyte antigen (HLA)-B*13:01 was reported as an 
      important risk factor for dapsone hypersensitivity syndrome (DHS) in Chinese and 
      Thai populations. RESEARCH DESIGN AND METHODS: From the Korean nationwide 
      registry, seven subjects with previous DHS were included. Their HLA 
      allele/phenotype frequencies were compared with 8 dapsone-tolerant subjects 
      recruited from a single institution, and general population (n = 485) in Korea. 
      The authors also performed a meta-analysis with these data using previous Chinese 
      and Thai studies. RESULTS: Among the seven DHS subjects, 85.7% presented with the 
      HLA-B*13:01 allele. The HLA-C*03:04, HLA-DRB1*12:02 (both in linkage 
      disequilibrium with HLA-B*13:01), and HLA-A*02:01 alleles were also presented in 
      85.7%, 71.4%, and 71.4%, respectively. Subjects with HLA-B*13:01 were susceptible 
      to developing DHS compared to dapsone-tolerant controls (odds ratio [OR]: 73.667) 
      and the Korean general population (OR: 139.500). HLA-C*03:04 (OR: 40.935), 
      HLA-DRB*12:02 (OR: 36.613), and HLA-A*02:01 (OR: 5.862) showed similar results. 
      In meta-analysis, HLA-B*13:01 was associated with dapsone-induced 
      hypersensitivity (overall OR: 42.692), and subgroup analyses according to the 
      control types demonstrated similar results (OR:43.694 and 41.866, respectively). 
      CONCLUSIONS: Similar to previous Asian population studies, HLA-B*13:01 is 
      significantly associated with the risk of DHS in Korea. These associations may be 
      useful for preventing DHS and improving drug safety.
FAU - Park, Hye Jung
AU  - Park HJ
AUID- ORCID: 0000-0002-1862-1003
AD  - Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University 
      College of Medicine , Seoul, Republic of Korea.
FAU - Park, Jung-Won
AU  - Park JW
AUID- ORCID: 0000-0003-0249-8749
AD  - Department of Internal Medicine, Severance Hospital, Yonsei University College of 
      Medicine , Seoul, Republic of Korea.
FAU - Kim, Sae Hoon
AU  - Kim SH
AUID- ORCID: 0000-0002-2572-5302
AD  - Department of Internal Medicine, Seoul National University Bundang Hospital , 
      Seongnam, Republic of Korea.
FAU - Choi, So-Yun
AU  - Choi SY
AD  - Department of Pediatrics, Inje University Haeundae Paik Hospital , Busan, 
      Republic of Korea.
FAU - Kim, Hee-Kyoo
AU  - Kim HK
AD  - Department of Internal Medicine, Kosin University College of Medicine , Busan, 
      Republic of Korea.
FAU - Jung, Chang-Gyu
AU  - Jung CG
AD  - Department of Internal Medicine, Keimyung University Dongsan Medical Center , 
      Daegu, Republic of Korea.
FAU - Yang, Min-Suk
AU  - Yang MS
AUID- ORCID: 0000-0002-9861-0530
AD  - Department of Internal Medicine, SMG-SNU Boramae Medical Center , Seoul, Republic 
      of Korea.
FAU - Kang, Dong Yoon
AU  - Kang DY
AUID- ORCID: 0000-0003-4283-2633
AD  - Drug Safety Monitoring Center, Seoul National University Hospital , Seoul, 
      Republic of Korea.
FAU - Cho, Min-Kyoung
AU  - Cho MK
AD  - Drug Safety Monitoring Center, Seoul National University Hospital , Seoul, 
      Republic of Korea.
FAU - Kwon, Hyouk-Soo
AU  - Kwon HS
AUID- ORCID: 0000-0001-7695-997X
AD  - Department of Internal Medicine, Asan Medical Center, University of Ulsan College 
      of Medicine , Seoul, Republic of Korea.
FAU - Kang, Hye-Ryun
AU  - Kang HR
AUID- ORCID: 0000-0002-2317-4201
AD  - Drug Safety Monitoring Center, Seoul National University Hospital , Seoul, 
      Republic of Korea.
AD  - Department of Internal Medicine, Seoul National University Hospital , Seoul, 
      Republic of Korea.
FAU - Lee, Yong Won
AU  - Lee YW
AUID- ORCID: 0000-0002-6174-3479
AD  - Department of Internal Medicine, International St. Mary's Hospital, Catholic 
      Kwandong University College of Medicine , Incheon, Republic of Korea.
CN  - Allergy Work Group of KAAACI
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20200818
PL  - England
TA  - Expert Opin Drug Saf
JT  - Expert opinion on drug safety
JID - 101163027
RN  - 0 (HLA-B13 Antigen)
RN  - 0 (Leprostatic Agents)
RN  - 8W5C518302 (Dapsone)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Child
MH  - Dapsone/administration & dosage/*adverse effects
MH  - Drug Hypersensitivity Syndrome/*etiology/genetics
MH  - Female
MH  - Genotype
MH  - HLA-B13 Antigen/*genetics
MH  - Humans
MH  - Leprostatic Agents/administration & dosage/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Registries
MH  - Republic of Korea
MH  - Risk Factors
OTO - NOTNLM
OT  - Dapsone
OT  - HLA-B*13:01
OT  - human leukocyte antigen
OT  - hypersensitivity syndrome
EDAT- 2020/07/24 06:00
MHDA- 2021/02/05 06:00
CRDT- 2020/07/24 06:00
PHST- 2020/07/24 06:00 [pubmed]
PHST- 2021/02/05 06:00 [medline]
PHST- 2020/07/24 06:00 [entrez]
AID - 10.1080/14740338.2020.1796965 [doi]
PST - ppublish
SO  - Expert Opin Drug Saf. 2020 Oct;19(10):1349-1356. doi: 
      10.1080/14740338.2020.1796965. Epub 2020 Aug 18.