PMID- 32702899
OWN - NLM
STAT- MEDLINE
DCOM- 20200803
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 29
DP  - 2020 Jul 17
TI  - Effectiveness of niacin supplementation for patients with type 2 diabetes: A 
      meta-analysis of randomized controlled trials.
PG  - e21235
LID - 10.1097/MD.0000000000021235 [doi]
LID - e21235
AB  - BACKGROUND: Lipid profiles and glycemic control play a critical role in 
      subsequent atherosclerotic cardiovascular disease for patients with type 2 
      diabetes mellitus (T2DM). This study aimed to evaluate the effectiveness of 
      niacin supplementation on lipid profiles and glycemic control for patients with 
      T2DM. METHODS: The PubMed, Embase, and the Cochrane Library databases were 
      searched to identify randomized controlled trials (RCTs) that investigated the 
      effects of niacin supplementation for patients with T2DM throughout December 
      2019. The weighted mean differences (WMDs) with 95% confidence intervals (CIs) 
      were applied to calculate the pooled effect estimates using a random-effects 
      model. RESULTS: Eight RCTs comprised a total of 2110 patients with T2DM who were 
      selected for final quantitative analysis. The patients' niacin supplementation 
      was associated with lower levels of total cholesterol (WMD, -0.28; 95% CI, -0.44 
      to -0.12; P = .001), triglyceride (WMD, -0.37; 95% CI, -0.52 to -0.21; P < .001), 
      and low-density lipoprotein (WMD, -0.42; 95% CI, -0.50 to -0.34; P < .001). 
      Moreover, the level of high-density lipoprotein was significantly increased when 
      niacin supplementation (WMD, 0.33; 95% CI, 0.21 to 0.44; P < .001) was provided. 
      However, niacin supplementation produced no significant effects on plasma glucose 
      (WMD, 0.18; 95% CI, -0.14 to 0.50; P = .275) and hemoglobin A1c (HbA1c) levels 
      (WMD, 0.39; 95% CI, -0.15 to 0.94; P = .158). CONCLUSIONS: This study found that 
      niacin supplementation could improve lipid profiles without affecting the 
      glycemic levels for patients with T2DM. Additional large-scale RCTs should be 
      conducted to evaluate the long-term effectiveness of niacin supplementation.
FAU - Xiang, Dan
AU  - Xiang D
AD  - Department of Endocrinology, Affiliated Taikang Xianlin Drum Tower Hospital, 
      Medical School of Nanjing University, Nanjing, Jiangsu, China.
FAU - Zhang, Qian
AU  - Zhang Q
FAU - Wang, Yang-Tian
AU  - Wang YT
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
RN  - 0 (Lipids)
RN  - 2679MF687A (Niacin)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy
MH  - *Dietary Supplements
MH  - Humans
MH  - Lipids/blood
MH  - Niacin/administration & dosage/*therapeutic use
MH  - Randomized Controlled Trials as Topic
MH  - Treatment Outcome
PMC - PMC7373507
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/07/25 06:00
MHDA- 2020/08/04 06:00
PMCR- 2020/07/17
CRDT- 2020/07/25 06:00
PHST- 2020/07/25 06:00 [entrez]
PHST- 2020/07/25 06:00 [pubmed]
PHST- 2020/08/04 06:00 [medline]
PHST- 2020/07/17 00:00 [pmc-release]
AID - 00005792-202007170-00094 [pii]
AID - MD-D-20-00586 [pii]
AID - 10.1097/MD.0000000000021235 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Jul 17;99(29):e21235. doi: 
      10.1097/MD.0000000000021235.