PMID- 32703207
OWN - NLM
STAT- MEDLINE
DCOM- 20210601
LR  - 20210601
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Jul 23
TI  - Relationship between pulmonary function and albuminuria in type 2 diabetic 
      patients with preserved renal function.
PG  - 112
LID - 10.1186/s12902-020-00598-1 [doi]
LID - 112
AB  - BACKGROUND: Albuminuria is the early manifestation of the pathogenesis of 
      diabetic nephropathy (DN). The current study was to investigate the relationship 
      of pulmonary function with albuminuria in type 2 diabetic patients with preserved 
      renal function to evaluate the role of pulmonary function in the early stage of 
      DN. METHODS: A total of 326 patients with type 2 diabetes mellitus (T2DM) 
      including 270 without albuminuria and 56 with albuminuria, and 265 non-diabetic 
      patients were enrolled. The patients' general information, and the parameters of 
      pulmonary function, including forced vital capacity (FVC), forced expiratory 
      volume in 1 s (FEV1), FEV1/FVC, total lung capacity (TLC), diffusion capacity for 
      carbon monoxide of lung (DLCO) were compared between T2DM and control groups, as 
      well as T2DM patients with and without albuminuria groups. All pulmonary function 
      parameters were expressed as a percentage of those predicted (%pred). Logistic 
      regression models were constructed to test the association of albuminuria and 
      pulmonary function. RESULTS: The values of FVC%pred, FEV1%pred, TLC%pred and 
      DLCO%pred were lower, and the proportion of subjects with FVC%pred < 80, 
      FEV1%pred < 80, and DLCOc%pred < 80 was higher in T2DM subjects than controls 
      (all P < 0.05). Subgroup analysis of diabetic patients showed that the values of 
      FVC%pred, FEV1%pred, TLC%pred, and DLCOc%pred (97.18 +/- 13.45, 93.95 +/- 14.51, 
      90.64 +/- 9.97, 87.27 +/- 13.13, respectively) were significantly lower in T2DM 
      subjects with albuminuria than those without albuminuria (103.94 +/- 14.12, 
      99.20 +/- 14.25, 93.79 +/- 10.36, 92.62 +/- 13.45, all P < 0.05). There was a 
      significantly negative correlation between the urine albumin-to-creatinine ratio 
      (UACR) and DLCOc%pred (r = - 0.143, P = 0.010) in spearman linear correlation 
      test. In logistic regression analysis, the FVC%pred (OR 0.965, 95%CI 
      0.944-0.988), FEV1%pred (OR 0.975, 95%CI 0.954-0.996), and DLCOc%pred (OR 0.974, 
      95%CI 0.951-0.998) were independently associated with albuminuria after 
      adjustments for smoking index, duration, HbA1c, FBG, and TG. CONCLUSION: Our 
      results demonstrated albuminuria is associated with a restrictive pulmonary 
      function as well as pulmonary diffusion function in T2DM with preserved renal 
      function, which remind us to be alert of the pulmonary function decline even in 
      the early stage of DN.
FAU - He, Yun-Yun
AU  - He YY
AD  - Department of General Internal Medicine, Beijing Chao-Yang Hospital, Capital 
      Medical University, Beijing, 100020, China.
FAU - Chen, Zhe
AU  - Chen Z
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing, 100020, China.
FAU - Fang, Xiang-Yang
AU  - Fang XY
AD  - Department of General Internal Medicine, Beijing Chao-Yang Hospital, Capital 
      Medical University, Beijing, 100020, China.
FAU - Chang, Jing
AU  - Chang J
AD  - Department of General Internal Medicine, Beijing Chao-Yang Hospital, Capital 
      Medical University, Beijing, 100020, China.
FAU - Lu, Yong
AU  - Lu Y
AD  - Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, 
      Capital Medical University, Beijing, 100020, China.
FAU - Wang, Xiao-Juan
AU  - Wang XJ
AD  - Department of General Internal Medicine, Beijing Chao-Yang Hospital, Capital 
      Medical University, Beijing, 100020, China. xjwang730715@sina.com.
LA  - eng
GR  - No.PX201804/Scientific Research Training Project of Beijing Hospital Authority./
GR  - PYZ2018029/Scientific Research Training Project of Capital Medical University/
PT  - Journal Article
DEP - 20200723
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria/complications/*physiopathology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Diabetic Nephropathies/diagnosis/etiology/physiopathology
MH  - Female
MH  - Forced Expiratory Volume
MH  - Glomerular Filtration Rate/physiology
MH  - Humans
MH  - Kidney/*physiology
MH  - Lung/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Respiratory Function Tests
MH  - Vital Capacity
PMC - PMC7379808
OTO - NOTNLM
OT  - Albuminuria
OT  - Preserved renal function
OT  - Pulmonary function
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no competing interests.
EDAT- 2020/07/25 06:00
MHDA- 2021/06/02 06:00
PMCR- 2020/07/23
CRDT- 2020/07/25 06:00
PHST- 2020/02/24 00:00 [received]
PHST- 2020/07/16 00:00 [accepted]
PHST- 2020/07/25 06:00 [entrez]
PHST- 2020/07/25 06:00 [pubmed]
PHST- 2021/06/02 06:00 [medline]
PHST- 2020/07/23 00:00 [pmc-release]
AID - 10.1186/s12902-020-00598-1 [pii]
AID - 598 [pii]
AID - 10.1186/s12902-020-00598-1 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2020 Jul 23;20(1):112. doi: 10.1186/s12902-020-00598-1.