PMID- 32703403
OWN - NLM
STAT- MEDLINE
DCOM- 20210210
LR  - 20210210
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 529
IP  - 2
DP  - 2020 Aug 20
TI  - Long noncoding RNA LINC01194 enhances the malignancy of laryngeal squamous cell 
      carcinoma by sponging miR-655 to increase SOX18 expression.
PG  - 148-155
LID - S0006-291X(20)31115-3 [pii]
LID - 10.1016/j.bbrc.2020.05.178 [doi]
AB  - Long noncoding RNAs (lncRNAs) have undergone a comprehensive study for their 
      involvements in tumor treatments. The purpose of our study was to explore the 
      biological effects and regulatory mechanisms of lncRNA LINC01194 (LINC01194) in 
      laryngeal squamous cell carcinoma (LSCC). The levels of LINC01194 in 105 LSCC 
      patients were detected by RT-qPCR. The diagnostic and prognostic value of 
      LINC01194 in LSCC patients were statistically analyzed. The potential functions 
      of LINC01194 in proliferation, apoptosis, and metastasis of LSCC cells were 
      evaluated. The interaction among LINC01194, miR-655 and SOX18 was explored by 
      bioinformatics analysis, luciferase reporter assays and biotinylated RNA 
      pull-down. We found that the expression levels of LINC01194 were highly expressed 
      in LSCC, which was negatively correlated with the clinical outcome of LSCC 
      patients. The area under the ROC curve for LINC01194 was up to 0.8388. Functional 
      assays indicated that LINC01194 knockdown distinctly inhibited LSCC cells 
      proliferation, induced apoptosis, and also attenuated LSCC cells migration and 
      invasion in vitro. Furthermore, we elucidated that LINC01194 promoted SOX18 
      expression in LSCC cells via functioning as a molecular sponge for miR-655. 
      Overall, based on our findings, LINC01194 served as a tumor promoter and 
      potentially represents a novel prognostic indicator and therapeutic target in 
      LSCC.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Liu, Da-Ming
AU  - Liu DM
AD  - Department of Head and Neck Surgery, The Harbin Medical University Cancer 
      Hospital, Harbin, Heilongjiang, China.
FAU - Yang, Hao
AU  - Yang H
AD  - Department of Head and Neck Surgery, The Harbin Medical University Cancer 
      Hospital, Harbin, Heilongjiang, China.
FAU - Yuan, Zhen-Nan
AU  - Yuan ZN
AD  - Department of Head and Neck Surgery, The Harbin Medical University Cancer 
      Hospital, Harbin, Heilongjiang, China.
FAU - Yang, Xian-Guang
AU  - Yang XG
AD  - Department of Head and Neck Surgery, The Harbin Medical University Cancer 
      Hospital, Harbin, Heilongjiang, China.
FAU - Pei, Rong
AU  - Pei R
AD  - Department of Head and Neck Surgery, The Harbin Medical University Cancer 
      Hospital, Harbin, Heilongjiang, China.
FAU - He, Hong-Jiang
AU  - He HJ
AD  - Department of Head and Neck Surgery, The Harbin Medical University Cancer 
      Hospital, Harbin, Heilongjiang, China. Electronic address: hjl157710@yeah.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200621
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (MIRN655 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (SOX18 protein, human)
RN  - 0 (SOXF Transcription Factors)
SB  - IM
MH  - Cell Line, Tumor
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/*genetics/pathology
MH  - MicroRNAs/*genetics
MH  - Prognosis
MH  - RNA, Long Noncoding/*genetics
MH  - SOXF Transcription Factors/*genetics
MH  - Squamous Cell Carcinoma of Head and Neck/diagnosis/*genetics/pathology
OTO - NOTNLM
OT  - Biomarker
OT  - Laryngeal squamous cell carcinoma
OT  - LncRNA LINC01194
OT  - Metastasis
OT  - SOX18
OT  - miR-655
COIS- Declaration of competing interest The Authors declare that they have no conflict 
      of interests.
EDAT- 2020/07/25 06:00
MHDA- 2021/02/11 06:00
CRDT- 2020/07/25 06:00
PHST- 2020/05/04 00:00 [received]
PHST- 2020/05/25 00:00 [accepted]
PHST- 2020/07/25 06:00 [entrez]
PHST- 2020/07/25 06:00 [pubmed]
PHST- 2021/02/11 06:00 [medline]
AID - S0006-291X(20)31115-3 [pii]
AID - 10.1016/j.bbrc.2020.05.178 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2020 Aug 20;529(2):148-155. doi: 
      10.1016/j.bbrc.2020.05.178. Epub 2020 Jun 21.