PMID- 32704147
OWN - NLM
STAT- MEDLINE
DCOM- 20201210
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 10
IP  - 1
DP  - 2020 Jul 23
TI  - Detection of synovitis in early knee osteoarthritis by MRI and serum biomarkers 
      in Japanese general population.
PG  - 12310
LID - 10.1038/s41598-020-69328-w [doi]
LID - 12310
AB  - To investigate synovitis' influence on early knee osteoarthritis (EKOA) by serum 
      biomarkers and magnetic resonance imaging (MRI) findings in Japanese women. We 
      enrolled 255 women aged 30-70 without radiographic abnormalities 
      (Kellgren-Lawrence grade >/= 2). Knee injury, OA outcome scores (KOOS), clinical 
      examinations, and standing radiograph were used for classification criteria of 
      EKOA. Participants were classified into normal knee group and EKOA group. All 
      participants underwent MRIs of their right knee. The amount of effusion-synovitis 
      volume was quantified. We compared serum matrix metalloproteinases-3 levels 
      (MMP-3), high-sensitivity C-reactive protein, interleukin-6, and adiponectin 
      between the groups. The relationship between synovitis and EOKA was investigated 
      using multiple linear regression. Fifty-four participants (21%) were classified 
      as EKOA. Serum MMP-3 concentration and effusion-synovitis volume were higher in 
      patients with EKOA (p = 0.025 and p = 0.001, respectively). Effusion-synovitis 
      volume negatively correlated with all KOOS subscales and positively correlated 
      with serum MMP-3 concentration. Serum MMP-3 concentration was associated with 
      effusion-synovitis volume beta = 0.60, p < 0.001). There was mildly active but 
      definitive synovitis in EKOA. This was an observational study so that no 
      conclusions can be drawn regarding cause-effect for synovitis and symptoms. 
      Future studies should conduct follow-up of participants with synovitis to assess 
      the progression of knee OA.
FAU - Ishibashi, Kyota
AU  - Ishibashi K
AD  - Department of Orthopaedic Surgery, Hirosaki University Graduate School of 
      Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan. 
      kyota.i@hirosaki-u.ac.jp.
FAU - Sasaki, Eiji
AU  - Sasaki E
AD  - Department of Orthopaedic Surgery, Hirosaki University Graduate School of 
      Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
FAU - Ota, Seiya
AU  - Ota S
AD  - Department of Orthopaedic Surgery, Hirosaki University Graduate School of 
      Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
FAU - Chiba, Daisuke
AU  - Chiba D
AD  - Department of Orthopaedic Surgery, Hirosaki University Graduate School of 
      Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
FAU - Yamamoto, Yuji
AU  - Yamamoto Y
AD  - Department of Orthopaedic Surgery, Hirosaki University Graduate School of 
      Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
FAU - Tsuda, Eiichi
AU  - Tsuda E
AD  - Department of Rehabilitation Medicine, Hirosaki University Graduate School of 
      Medicine, Hirosaki, Japan.
FAU - Yoshikuni, Sugimura
AU  - Yoshikuni S
AD  - Department of Social Medicine, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Ihara, Kazushige
AU  - Ihara K
AD  - Department of Social Medicine, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Ishibashi, Yasuyuki
AU  - Ishibashi Y
AD  - Department of Orthopaedic Surgery, Hirosaki University Graduate School of 
      Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200723
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Asian People
MH  - Biomarkers/*blood
MH  - Female
MH  - Humans
MH  - Japan
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Osteoarthritis, Knee/*blood/diagnosis/*diagnostic imaging
MH  - ROC Curve
MH  - Synovial Membrane/pathology
MH  - Synovitis/*blood/diagnosis/*diagnostic imaging
PMC - PMC7378056
COIS- The authors declare no competing interests.
EDAT- 2020/07/25 06:00
MHDA- 2020/12/15 06:00
PMCR- 2020/07/23
CRDT- 2020/07/25 06:00
PHST- 2020/03/17 00:00 [received]
PHST- 2020/07/08 00:00 [accepted]
PHST- 2020/07/25 06:00 [entrez]
PHST- 2020/07/25 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/07/23 00:00 [pmc-release]
AID - 10.1038/s41598-020-69328-w [pii]
AID - 69328 [pii]
AID - 10.1038/s41598-020-69328-w [doi]
PST - epublish
SO  - Sci Rep. 2020 Jul 23;10(1):12310. doi: 10.1038/s41598-020-69328-w.