PMID- 32707364
OWN - NLM
STAT- MEDLINE
DCOM- 20201207
LR  - 20240226
IS  - 1873-7072 (Electronic)
IS  - 0308-8146 (Linking)
VI  - 334
DP  - 2021 Jan 1
TI  - Matrix-assisted laser desorption/ionization mass spectrometry-guided 
      visualization analysis of intestinal absorption of acylated anthocyanins in 
      Sprague-Dawley rats.
PG  - 127586
LID - S0308-8146(20)31448-5 [pii]
LID - 10.1016/j.foodchem.2020.127586 [doi]
AB  - It is unknown whether intestinal absorption of acylated anthocyanins occurs in 
      their intact or metabolized form. In this study, with the aid of matrix-assisted 
      laser desorption/ionization mass spectrometry (MALDI-MS) imaging, intestinal 
      absorption of acylated anthocyanins was visually investigated. Anthocyanin 
      extracts from purple carrots were orally administered to Sprague-Dawley rats. 
      Acylated cyanidins were absorbed into portal and circulating blood systems in 
      their intact form, and aglycon; cyanidin 
      3-O-(6-O-feruloyl-beta-d-glucopyranosyl)-(1 --> 6)-[beta-d-xylopyranosyl-(1 --> 2)]-beta-d-galactopyranoside 
      (Cy3XFGG), and showed a high absorption of 39.3 +/- 0.1 pmol/mL-plasma at 60 min 
      after administration. MALDI-MS imaging analysis of the rat jejunum membranes 
      showed that an organic anion transporting polypeptide (OATP) transporter was 
      involved in Cy3XFGG transport, while deacylated anthocyanins were incorporated 
      through both the glucose transporter 2 and OATP routes. In conclusion, acylated 
      anthocyanin, Cy3XFGG, can be absorbed in its intact form through intestinal OATP.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Hahm, Tae Hun
AU  - Hahm TH
AD  - Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 819-0395, 
      Japan.
FAU - Tanaka, Mitsuru
AU  - Tanaka M
AD  - Research and Development Center for Five-Sense Devices, Kyushu University, 
      Fukuoka 819-0395, Japan.
FAU - Nguyen, Huu-Nghi
AU  - Nguyen HN
AD  - Department of Science and International Collaboration, Institute for Research and 
      Development of Organic Products, 176 Phung Khoang, Trung Van, Nam Tu Liem, Hanoi, 
      Viet Nam.
FAU - Tsutsumi, Ayaka
AU  - Tsutsumi A
AD  - Innovation Division, Kagome Co., Ltd., 17 Nishitomiyama, Nasushiobara, Tochigi 
      329-2762, Japan.
FAU - Aizawa, Koichi
AU  - Aizawa K
AD  - Innovation Division, Kagome Co., Ltd., 17 Nishitomiyama, Nasushiobara, Tochigi 
      329-2762, Japan.
FAU - Matsui, Toshiro
AU  - Matsui T
AD  - Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 819-0395, 
      Japan; Research and Development Center for Five-Sense Devices, Kyushu University, 
      Fukuoka 819-0395, Japan. Electronic address: tmatsui@agr.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20200718
PL  - England
TA  - Food Chem
JT  - Food chemistry
JID - 7702639
RN  - 0 (Anthocyanins)
RN  - 0 (Organic Anion Transporters)
RN  - 0 (Plant Extracts)
SB  - IM
MH  - Acylation
MH  - Administration, Oral
MH  - Animals
MH  - Anthocyanins/administration & dosage/*analysis/*pharmacokinetics
MH  - Color
MH  - Daucus carota/chemistry
MH  - Intestinal Absorption/drug effects
MH  - Jejunum/drug effects/metabolism
MH  - Male
MH  - Molecular Imaging/*methods
MH  - Organic Anion Transporters/metabolism
MH  - Plant Extracts/administration & dosage/pharmacokinetics
MH  - Rats, Sprague-Dawley
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods
MH  - Rats
OTO - NOTNLM
OT  - Absorption
OT  - Acylated anthocyanin
OT  - Intestinal transport
OT  - MALDI-MS imaging
OT  - OATP route
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2020/07/25 06:00
MHDA- 2020/12/15 06:00
CRDT- 2020/07/25 06:00
PHST- 2020/05/15 00:00 [received]
PHST- 2020/07/08 00:00 [revised]
PHST- 2020/07/12 00:00 [accepted]
PHST- 2020/07/25 06:00 [pubmed]
PHST- 2020/12/15 06:00 [medline]
PHST- 2020/07/25 06:00 [entrez]
AID - S0308-8146(20)31448-5 [pii]
AID - 10.1016/j.foodchem.2020.127586 [doi]
PST - ppublish
SO  - Food Chem. 2021 Jan 1;334:127586. doi: 10.1016/j.foodchem.2020.127586. Epub 2020 
      Jul 18.